A5030716576- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Chromatin Remodeling and Cancer
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- RNA Research and Splicing
- Insect symbiosis and bacterial influences
- Gout, Hyperuricemia, Uric Acid
- Aldose Reductase and Taurine
- Advanced Nanomaterials in Catalysis
- Adenosine and Purinergic Signaling
- Cancer Mechanisms and Therapy
- bioluminescence and chemiluminescence research
- Animal Nutrition and Physiology
- interferon and immune responses
- Berberine and alkaloids research
- Synthesis and Biological Evaluation
- Antimicrobial Resistance in Staphylococcus
- Microbial Fuel Cells and Bioremediation
- Genomics, phytochemicals, and oxidative stress
- DNA and Nucleic Acid Chemistry
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
- Antibiotic Resistance in Bacteria
- Luminescence Properties of Advanced Materials
Institute of Gene Biology
2023-2025
Southern Federal University
2015-2023
Rostov Research Institute of Oncology
2018
Abstract The IMD and Toll signaling pathways in Drosophila melanogaster mediate the innate immune responses to Gram-negative Gram-positive bacteria fungi, respectively. Here we studied involvement of NF-κB transcription factor Relish, which is a mediator pathway, humoral response Micrococcus luteus Bacillus subtilis entomopathogenic fungus Metarhizium anisopliae , using D. S2 cells as model. Activation Relish proteolysis was observed after cell treatment with control bacterium Escherichia...
Background: Berberine has multitudinous anti-cancer stem cells effects making it a highly promising candidate substance for the next-generation cancer therapy. However, berberine modes of action predispose to significant side-effects that probably limit its clinical testing and application. Materials Methods: HeLa were treated with two concentrations (30 100 µM) 24 hours assess functioning NFE2L2/AP-1, NFκB HIF1A pathways using 22 RNAs expression qPCR-based analysis. Results: appeared be...
SAYP and Bap170, subunits of the SWI/SNF remodeling complex, have ability to support enhancer-dependent transcription when artificially recruited promoter on a transgene. We found that phenomenon critically depends two Mediator kinase module, Med12 Med13 but does not require other module (Cdk8 CycC) or core part complex. A cooperation above proteins in active was also observed at endogenous loci, contribution activity particular gene differed different loci. The factors SAYP/Bap170...
The phenotypic manifestations of increased expression the Bap170 and e(y)3 (SAYP) genes in D. melanogaster were analyzed. Using wing disc model, we show that moderate co-expression discs leads to abnormalities veining. which was probably caused by suppression EGFR/Ras/MAPK signaling pathways. Strong induction above complete development adults. Ubiquitous is lethal at 1st instar larval stage formation melanotic tumors. phenotypes are observed exclusively when co-expressed. This evidence...
Humoral innate immunity is highly conserved in all eukaryotes. Drosophila a classic organism to study the molecular mechanisms of immunity. The response driven are by IMD and Toll signaling pathways. Here we describe use Schneider S2 cell line as model system To find optimal conditions for activation immune genes, which activated pathways, used various concentrations inactivated cultures Escherichia coli Micrococcus luteus spores Metarhizium anisopliae. High levels genes antimicrobial...
SWI/SNF complexes are ATP-dependent chromatin remodeling that regulate the expression of numerous genes through use at least 15 subunits. The composition these is diverse, a result combinatory assembly subunits from homologous families with variety additional functions. During neurogenesis, researchers have identified distinctive specific to various stages development. These were detected in stem cells, neuronal progenitor and postmitotic differentiated neurons. Notably, cells essential for...