A5050288188- Advanced Proteomics Techniques and Applications
- Supramolecular Chemistry and Complexes
- Mass Spectrometry Techniques and Applications
- Biochemical effects in animals
- Metabolomics and Mass Spectrometry Studies
- Molecular Sensors and Ion Detection
- Synthesis and properties of polymers
- Physiological and biochemical adaptations
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Radioactive element chemistry and processing
- Coenzyme Q10 studies and effects
- Fullerene Chemistry and Applications
- Advanced Polymer Synthesis and Characterization
- Ubiquitin and proteasome pathways
- Biochemical Acid Research Studies
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- RNA Research and Splicing
- Orthopedic Infections and Treatments
- Insect symbiosis and bacterial influences
- Protein Hydrolysis and Bioactive Peptides
- Ionic liquids properties and applications
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
Institute of Biomedical Chemistry
2015-2025
Institute of Biology of Inland Waters named Ivan Dmitrievich Papanin
2023-2024
Russian Academy of Sciences
2009-2024
Academy of Medical Sciences
2008-2014
Twenty‐nine human aqueous humor samples from patients with eye diseases such as cataract and glaucoma without pseudoexfoliation syndrome were characterized by LC–high resolution MS analysis. In total, 269 protein groups identified 1% false discovery rate including 32 that not reported previously for this biological fluid. Since the analyzed individually, but pooled, 36 proteins in all samples, comprising constitutive proteome of The most dominant molecular function determined GO analysis is...
The nucleotide context surrounding stop codons significantly affects the efficiency of translation termination. In eukaryotes, various 3′ contexts that are unfavorable for termination have been described; however, exact molecular mechanism mediates their effects remains unknown. this study, we used a reconstituted mammalian system to examine in different contexts, including several previously described weak codon contexts. We developed an approach estimate level readthrough absence...
Chronic imbalance between production and degradation of the human amyloid-beta peptide (Abeta) is assumed to play an important role in pathogenesis Alzheimer's disease (AD). Post-translational modifications Abeta could influence its interactions with specifically cleaving proteases and, therefore, perturb homeostasis. The angiotensin-converting enzyme (ACE) was previously shown degrade non-modified vitro cells. In presented work, we investigated effect isomerization Asp-7, a common...
The new initiator of the polymerization acrylamide, leading to formation crosslinked polyacrylamide, was discovered. structure synthesized polyacrylamide characterized by XRD, 1Н NMR, and 13С NMR spectroscopy. It shown that 1,3-dimethylimidazolium (phosphonooxy-)oligosulphanide is able initiate radical under drying aqueous solutions even at room temperature. According XRF data, gel contains 0.28 wt% sulphur. formed polymer network has a low crosslinking density high equilibrium degree...
Achromobacter insolitus and aegrifaciens, bacterial degraders of the herbicide glyphosate, were found to induce phosphonatase (phosphonoacetaldehyde hydrolase, EC 3.11.1.1) when grown on minimal media with glyphosate as sole source phosphorus. The phosphonatases strains purified an electrophoretically homogeneous state characterized. enzymes differed in their kinetic characteristics some other parameters from previously described phosphonatases. A. was first revealed separate into two stable...
Co-delivery of chemotherapeutics in cancer treatment has been proven essential for overcoming multidrug resistance and improving the outcome therapy. We report synthesis amphiphilic copolymers N-vinyl-2-pyrrolidone allyl glycidyl ether various compositions demonstrate that they can form nanoaggregates capable simultaneous covalent immobilization doxorubicin by epoxy groups shell hydrophobic-driven incorporation paclitaxel into core nanoparticles. The structure obtained was characterized 13C...
A number of polycyclic azole systems on the 1,1'-dinaphthylmethane and rccc, rctt resorcinarene platforms were formed, isolated in high yields, characterized. The products include homofunctionalized derivatives containing 2, 4, or 8 functional branches with terminal tetrazole groups; heterofunctionalized two heterocycles, triazole tetrazole, each substituent present structure; hybrid derivative cyclophosphate moieties located horizontally arranged benzene rings triazolyltetrazole vertical...
Abstract The IMD and Toll signaling pathways in Drosophila melanogaster mediate the innate immune responses to Gram-negative Gram-positive bacteria fungi, respectively. Here we studied involvement of NF-κB transcription factor Relish, which is a mediator pathway, humoral response Micrococcus luteus Bacillus subtilis entomopathogenic fungus Metarhizium anisopliae , using D. S2 cells as model. Activation Relish proteolysis was observed after cell treatment with control bacterium Escherichia...
A database of Prostate Cancer Proteomics has been created by using the results a proteomic study human prostate carcinoma and benign hyperplasia tissues, some human-cultured cell lines (PCP, http://ef.inbi.ras.ru). PCP consists 7 interrelated modules, each containing four levels biomedical data on proteins in corresponding tissues or cells. The first level, onto which module is based, 2DE reference map where separated 2D electrophoresis, subsequently identified mass-spectrometry, are marked....
Paip2 (Poly(A)-binding protein – interacting 2) is a conserved metazoan-specific that has been implicated in regulating the translation and stability of mRNAs. However, we have found not restricted to cytoplasm but also nucleus Drosophila embryos, salivary glands, testes, tissue culture cells. Nuclear associated with chromatin, chromatin immunoprecipitation experiments it maps promoter regions active genes. this association indirect, as RNA-dependent. Thus, one more item growing list factors...
Abstract By the methods of MALDI and mass spectroscopy with detection positively negatively charged ions, it was found that reaction elemental sulfur 1,3-dimethylimidazolium dimethylphosphate is accompanied by opening S 8 ring. 1 H, 13 C, 15 N 31 P NMR showed interaction proceeds exclusively on oxygen atom anion carrying a negative charge. Kohn-Sham calculations at B3LYP/STO-3G, B3LYP/6-31G* B3LYP/6-311G* levels theory confirmed possible.
Doxorubicin is one of the widely known and frequently used chemotherapy drugs for treatment various types cancer, use which difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed reduce side effects. One promising components as vector molecules (ligands) NGR-containing peptides that affinity CD13 receptor, expressed on surface many tumor cells blood vessels. Previously, a method was preparing composition doxorubicin embedded in phospholipid nanoparticles...