A5046299460- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Insect Pest Control Strategies
- Crystallography and molecular interactions
- Cancer therapeutics and mechanisms
- Concrete Corrosion and Durability
- Corrosion Behavior and Inhibition
- Insect Resistance and Genetics
- Agricultural pest management studies
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Chemical Reaction Mechanisms
- Insect and Pesticide Research
- Birth, Development, and Health
- Pregnancy and Medication Impact
Sohag University
2016-2025
King Salman International University
2023-2024
Mayo Clinic
2023
Voronezh State University
2012
Ain Shams University
1980
This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that tested exhibited a range activities these insects, with compound 3b being most toxic 4a least effective. The LC50 value was 1.72 ppm for adults 0.02 nymphs while 72.51 18.02 nymphs. also presents structure-activity relationships compounds. These results...
Quinazoline compounds have gained significant attention in the fields of agriculture and chemistry due to their diverse activities. In this study, we focused on a series quinazoline derivatives (4a–l). The objectives involved multiple aspects, including preparation, evaluation agricultural bioactivity against maize aphid (Rhopalosiphum maidis), estimation structure–activity relationships (SAR), conducting molecular docking analysis. results bioactivities revealed that compound (4b) possesses...
Abstract A novel series of 1 : cocrystals 2‐cyanoguanidinophenytoin (CNG‐DPH) with primary, secondary, and tertiary aliphatic amines has been presented through this work. The antimicrobial activities all new CNG‐DPH‐amine were studied. existence proven crystal structure results. 5‐Oxo‐4,4‐diphenylimidazolidin‐2‐ylidenecyanamide‐piperidine cocrystal (10) is located in an orthorhombic system, the connected via N−H−N hydrogen bond between cyanide group piperidine molecule. Hirshfeld surface...
Iisatin hybrids have emerged as effective weapons against diseases. In this context, chalcone tethered isatin-coumarin hybrid 3 was synthesized and used a building block for the preparation of new series isatin-pyrazole, isatin-bridged dibenzo-diazonin 4–10 by reaction with ammonium acetate or primary aromatic amines. The were linked bioactive linkers named ethene, furan, pyrrole its derivatives. Through another route, polyfused pyrano-indoles 11–13 one pot isatin - coumarin some amines...
This work includes the synthesis of ten heterocyclic compounds (3a-i and 4) containing pyrimidine moiety incorporated in their structures. Structure characterizations these were performed by using elemental spectroscopic analyses. Their toxicity as potential insecticidal agents against adults nymphs cowpea Aphid, Aphis craccivora Koch was evaluated. The results this toxicological activity test revealed that a reasonable number possess excellent aphids such (3d), (3c), (3b) with LC50 values...
Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised evaluated for their inhibitory activity against iNOS PGE2. The most potent derivatives further checked in vivo anti-inflammatory utilising carrageenan-induced rat paw oedema model. Compounds 4c, 4d, 6c 6d proved to be the effective inhibitors PGE2, LPS-induced NO production, activity. Moreover, showed significant inhibition ranging from 62.21% 78.51%, compared indomethacin (56.27 ± 2.14%) celecoxib (12.32%)....
Pyridin‐2‐yl‐ and 4,6‐dimethylpyrimidin‐2‐yl‐cyanamides entered into an alkylation reaction in the form of sodium salts. Pyridin‐2‐yl cyanamide 2 was alkylated at endo‐nitrogen atom pyridine ring, while 4,6‐dimethylpyrimidin‐2‐yl 1 effectively exo‐nitrogen amino group. The cyanamides with phenacylbromide gave corresponding acetophenone derivatives. As a result their intramolecular cyclization reactions 3‐(4,6‐dimethylpyrimidin‐2‐yl)‐5‐phenyloxazol‐2(3 H )‐imine case...
Mustafa R. Albayatia, Mamdouh F. A. Mohamedb & Amr H. Moustafac* a Department of Chemistry, College Education, Kirkuk University, Kirkuk, Iraq; b Pharmaceutical Faculty Pharmacy, Sohag Sohag, Egypt; c Science, Egypt
New heterocycles containing 2‐aminopyrimidine moiety linked with pyrazino[1,2‐ c ]pyrimidines, thieno[2,3‐ d benzimidazoles, benzothiazoles, and benzoxazoles have been prepared by an efficient method starting from N ‐(pyrimidin‐2‐yl)cyanamides.
A novel series of 5,7-diamino-4-aryl-6-cyano-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines (aryl-CIDHPPMs) 3a–i was prepared via the one-pot four-component reaction cyanoguanidine with aromatic aldehydes and malononitrile molar ratio (1:1:2) using sodium methoxide as catalyst. These new polyfunctionlized aryl-CIDHPPMs were also synthesized by a classical route respective arylidenes dimer under same condition. In manner, isatinylidene afforded spiro-pyrido[2,3-d]pyrimidines 7. While...
A series of 3-acetyl-2-aryl-5-methylthio-2,3-dihydro-1,3,4-thiadiazoles 3a–g, N- (4-acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl) acetamide derivatives 5a–e and spiro-compound 7 was prepared from starting material dithiocarbazates using N-methylpyrrolidone (NMP) /acetic anhydride mixture. Furthermore, a new 5-amino-3- (methylthio) -1-substituted-1H-pyrazole-4-carbonitrile 12a–d two synthetic routes: (i) via reaction bis methylene malononitrile 8 with carbothiohydrazides 11a–d, or (ii)...
Hybridization has recently emerged as a promising strategy for discovering new drugs. Therefore, given the important bioactivity of isatins well coumarins, several hybrids based on isatin and coumarin nuclei were proposed, synthesized, characterized in this study. Using simple modified dehydration reaction, 3-hydroxy-3-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl] indolin-2-one was used starting material preparation 3-(2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyli-dene) (2) with high yield compared to...
A high-yielding synthetic route towards pyrazolyl-[1,2,4]triazole derivatives has been developed via one-pot multicomponent reaction of polyfunctionalized triazoles, DMF–DMA, acetophenone, ethyl cyanoacetate, and/or 3-oxo-3-phenylpropanenitrile in <i>ortho</i>-phosphoric acid (85%). In the same manner, a new series 2-triazolyl-tetrahydro-indazol-4-ones and pyrazolo[3,4-<i>d</i>]pyrimidines synthesized by DMF–DMA 1,3-cyclohexanediones barbituric acid, respectively. The products were prepared...