A5059868869- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiac Fibrosis and Remodeling
- Intracranial Aneurysms: Treatment and Complications
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Cardiac Ischemia and Reperfusion
- SARS-CoV-2 and COVID-19 Research
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Adipose Tissue and Metabolism
- Nuclear Structure and Function
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
- Pharmacological Effects and Assays
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- Mitochondrial Function and Pathology
Medical University of Graz
2022-2023
University of Regensburg
2020-2021
University Hospital Regensburg
2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic challenges national health systems and the global economy. Monitoring of infection rates seroprevalence can guide public measures to combat pandemic. This depends on reliable tests active former infections. Here, we set out develop validate a specific sensitive enzyme linked immunosorbent assay (ELISA) for detection anti-SARS-CoV-2 antibody levels.In our ELISA, used SARS-CoV-2 receptor-binding domain (RBD) stabilized...
Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown reduce material thrombogenicity promote endothelial cell proliferation in vitro. We compared biocompatibility coated (Derivo Heal) non-coated bare) FDs with DAPT an animal model.Derivo® bare (n = 10) Derivo® Heal FD were implanted common carotid arteries (CCAs) New Zealand white rabbits. One...
Abstract This study aimed to investigate in vivo two stent technologies, with particular emphasis on thrombogenicity and inflammatory vessel remodeling processes. The micro-stents tested this were developed for intracranial aneurysm treatment. In our twelve, New Zealand white rabbits divided into groups: 18 laser-cut stents (LCS) braided (BS) impanated without admiration of antiplatelet medication. Three implanted each animal the common carotid artery, subclavian abdominal aorta. Digital...
Excessive β-adrenergic stimulation and tachycardia are potent triggers of cardiac remodeling; however, their exact cellular effects remain elusive. Here, we sought to determine the potency modulate gene expression profiles cardiomyocytes. Using neonatal rat ventricular cardiomyocytes, showed that caused a significant upregulation sodium-calcium exchanger (NCX) activation calcium/calmodulin-dependent kinase II (CaMKII) in nuclear region. Acute isoprenaline treatment ameliorated...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): BioTechMed Graz Objective Cardiac remodelling encompasses changes at the molecular, cellular and gene expression level following pathologic insult to heart. Initially, it maintains cardiovascular homeostasis allows patients remain asymptomatic, but if untreated, eventually progresses symptomatic heart failure. Excessive β-adrenergic stimulation tachycardia are potent triggers cardiac remodelling; however,...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): BioTechMed Graz Objective Chronic activation β1-adrenergic receptors (β1AR) in response to hypertension is consistently linked maladaptive remodelling the heart, however, underlying mechanisms are not well understood. Here, our aim was determine subcellular profile and extent β1AR expression at baseline upon acute β-adrenergic stimulation cardiac myocytes during early- late-stage due systemic hypertension....
A Correction to this paper has been published: https://doi.org/10.1007/s10856-021-06518-6