A5013221483- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Neonatal and Maternal Infections
- Helminth infection and control
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Parasite Biology and Host Interactions
- Allergic Rhinitis and Sensitization
- Inflammatory Bowel Disease
- Dermatology and Skin Diseases
- Parasitic Infections and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Emergency and Acute Care Studies
- Parasites and Host Interactions
- Identification and Quantification in Food
- Pharmaceutical and Antibiotic Environmental Impacts
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Pediatric health and respiratory diseases
- Essential Oils and Antimicrobial Activity
Statens Serum Institut
2016-2025
University of Amsterdam
2024
Narodowy Instytut Leków
2024
University of California, Irvine
2024
UK Health Security Agency
2024
Instituto de Salud Carlos III
2024
GlaxoSmithKline (India)
2024
Boehringer Ingelheim (China)
2024
National Institute of Public Health
2024
RWTH Aachen University
2024
Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, leading causes of invasive diseases, including bacteraemic pneumonia meningitis, secondary infections subsequent to post-viral disease. The aim this study was investigate the incidence disease due these pathogens during early months COVID-19 pandemic.In prospective analysis surveillance data, laboratories in 26 countries territories across six continents...
Background. The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) at population level is unclear. We explored PCV13's effect in reducing invasive disease (IPD)–related morbidity and mortality, whether serotype-specific changes were attributable to vaccination or expected as a part natural, cyclical variations.
BackgroundThe Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and agalactiae. We aimed analyse incidence distribution these during first 2 years compared preceding pandemic.MethodsFor this prospective analysis, laboratories in 30 countries territories representing five continents submitted surveillance data from Jan...
We identified three isolates of Streptococcus agalactiae (group B streptococcus [GBS]), human origin, which failed to react with antisera against any the nine known GBS serotypes. Polyclonal rabbit raised these and standard typing sera were used in capillary precipitation Ouchterlony tests compare strains serotype reference strains. All previously nontypeable reacted all new antisera, producing lines identity test. Weak cross-reactions several serotypes observed but removed by absorption...
Background Pneumococcal conjugate vaccines (PCVs) have the potential to prevent pneumococcal disease through direct and indirect protection. This multicentre European study estimated effects of 5-year childhood PCV10 and/or PCV13 programmes on invasive (IPD) in older adults across 13 sites 10 countries, support decision-making vaccination policies. Methods For each site we calculated IPD incidence rate ratios (IRR) people aged ≥65 years by serotype for PCV10/13 year (2011–2015) compared with...
ObjectivesTo isolate a plant-derived compound with efflux inhibitory activity towards the NorA transporter of Staphylococcus aureus.
To study population kinetics during primary Ascaris suum infections, 3 groups of 52 pigs each were inoculated with 100, 1000, or 10000 infective eggs. In all groups, the majority larvae was found in liver on day post inoculation (p.i.) and lungs 7 p.i. Liver white spots, caused by migrating larvae, most numerous at p.i., whereafter they gradually healed, only low numbers granulation-tissue type spots lymphonodular persisted days 21–56 Independent dose level, 47–58% eggs recovered as small...
Abstract The aim of this study was to investigate the amount protein in stratum corneum atopic dermatitis (AD) patients and healthy controls, using tape stripping technique. Furthermore, compare two different methods for assessment. Tape performed AD controls collect samples subsequently analysed with methods: Squame Scan, which gives an estimate total (soluble insoluble) Micro BCA determination kit measures soluble protein. Significant differences cumulative content between lesional,...
ABSTRACT The “gold standard” for epidemiological typing of Streptococcus pneumoniae (pneumococcus) is the capsular reaction test (Neufeld test) with antisera against 90 pneumococcal polysaccharide capsules, i.e., serotyping. method labor intensive and requires a certain level experience to be performed satisfactory, thus it has been restricted use in specialized reference or research laboratories. Surveillance serotype distribution pneumococci that cause infections important secure an...
Skin infections related to disrupted antimicrobial defence are a common problem in atopic dermatitis (AD). Altered levels of peptides, including human β-defensin (hBD)-2, have been reported AD skin, and link impaired barrier function has suggested.To study hBD-2 relation skin patients with controls, disease severity.Twenty-five 11 controls were enrolled. peptide concentration was determined stratum corneum samples collected by minimally invasive tape-stripping method. Disease severity...
Since 2010, Denmark has included the 13-valent pneumococcal conjugated vaccine (PCV-13) in childhood immunization programme. However, serotype 3 remains as an important cause of invasive disease (IPD) Denmark. IPD surveillance data (1999–2016) was used to calculate incidence and age-distribution IPD, effect PCV-13 on examined. The age group below 65 years 0.51/100,000 pre PCV-13, 0.45/100,000 post PCV-13. In 0–4 years, 0.28/100,000 0.16/100,000 Serotype elderly showed a mean 4.27/100,000...
The commensal species Streptococcus mitis and oralis are genetically diverse to a degree that challenges traditional definitions of species. This causes automatic identification based on DNA sequences or cellular extract profiles problematic. Based an initial analysis 266 genomes, we subjected subset 100 representative genomes detailed phylogenetic, pairwise distance gene pattern analyses. S. constitute continuum clones unique. To recognize most isolates as separate is biologically...
During the course of carrying out studies on role intestinal immunity in blocking migration larval Ascaris suum pig, it was discovered that prevailing understanding penetration sites at variance with our observations. Therefore, a detailed investigation A. 1.2 larvae through intestine initiated. The results demonstrate invade almost exclusively wall pig cecum and colon not small as is generally believed. were recovered from mucosa early 3 hr postinoculation (PI) infective eggs liver by 6 PI....
Decreased levels of antimicrobial peptides (AMPs) in atopic dermatitis (AD) have previously been reported and linked to the increased susceptibility skin infections found AD patients. This study intents identify AMPs: hBD-2, hBD-3, RNase7, psoriasin LL-37 patients healthy controls, determine concentrations consecutive depths outer most layers. Tape stripping was used on lesional non-lesional skin. From each site, 35 tape strips were collected pooled groups 5. Commercially available ELISA...