Robert Mulhall
A5053903777- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Radiopharmaceutical Chemistry and Applications
- Data-Driven Disease Surveillance
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Zoonotic diseases and public health
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Monoclonal and Polyclonal Antibodies Research
- Vaccine Coverage and Hesitancy
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
Children's Health Ireland at Crumlin
2020-2024
Beaumont Hospital
2021
Temple Street Children's University Hospital
2004-2019
Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, leading causes of invasive diseases, including bacteraemic pneumonia meningitis, secondary infections subsequent to post-viral disease. The aim this study was investigate the incidence disease due these pathogens during early months COVID-19 pandemic.In prospective analysis surveillance data, laboratories in 26 countries territories across six continents...
BackgroundThe Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and agalactiae. We aimed analyse incidence distribution these during first 2 years compared preceding pandemic.MethodsFor this prospective analysis, laboratories in 30 countries territories representing five continents submitted surveillance data from Jan...
The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage vaccine. From panel 3912 MATS-typed invasive meningococcal disease collected England and Wales 2007–2008, 2014–2015 2015–2016, 16 other countries 2000–2015, 3481 were...
ABSTRACT PCR-based assays for the identification of Neisseria meningitidis serogroups 29E, X, and Z by detection specific regions ctrA gene are described. The specificities these were confirmed using A, B, C, H, W135, Y, nongroupable meningococcal isolates.
Neisseria meningitidis is a common cause of bacterial meningitis in children and young adults worldwide. The 4CMenB vaccine (Bexsero), developed to combat meningococcal serogroup B (MenB) disease, contains subcapsular antigens that may induce immunity against strains N. meningitidis, regardless serogroup. Owing differential levels expression peptide diversity across strains, the antigen typing system (MATS) was estimate potential MenB strain coverage 4CMenB. Prior introducing into routine...
ABSTRACT A carriage study was undertaken ( n = 112) to ascertain the prevalence of Neisseria spp. following eighth case invasive meningococcal disease in young children (5 46 months) and members a large extended indigenous ethnic minority Traveller family 123), typically associated with high-occupancy living conditions. Nested multilocus sequence typing (MLST) employed for specimen extracts. Isolates were genome sequenced then assembled de novo deposited into Bacterial Isolate Genome...
Between March 2010 and November 2013 eight laboratory-confirmed cases of serogroup B, invasive meningococcal disease (IMD) were identified in an extended Irish Traveller family across three Health Service Executive (HSE) areas Ireland. Cases aged between 5 46 months, either a cousin or sibling another case. All survived. Chemoprophylaxis was given to relevant nuclear members close contacts on each occasion, but failed prevent further cases. Neisseria meningitidis isolates from six highly...
Abstract Background Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis are leading causes of invasive diseases including bacteraemic pneumonia meningitis, secondary infections post-viral respiratory disease. They typically transmitted via droplets. We investigated rates disease due to these pathogens during the early phase COVID-19 pandemic. Methods Laboratories in 26 countries across six continents submitted data on cases S H N from 1 January 2018 31 May 2020....
Since 2013 MenC and MenW disease incidence associated mortality rates have increased in the Republic of Ireland. From 2002/2003 to 2012/2013, average annual was 0.08/100,000, which 0.34/100,000 during 2013/2014 2017/18, peaking 2016/17 (0.72/100,000) with an case fatality rate (CFR) 14.7%. has each year from 0.02/100,000 2013/2014, 0.29/100,000 CFR 28.6%. We aimed characterise relate recent isolates previously prevalent MenC:cc11 ET-15 clones, also novel 'Hajj' clones.Using WGS we...
Introduction The ST-4821 complex (cc4821) is a leading cause of serogroup C and B invasive meningococcal disease in China where diverse strains two phylogenetic groups (groups 1 2) have acquired fluoroquinolone resistance. cc4821 was recently prevalent among carriage isolates men who sex with New York City (USA). Genome-level population studies thus far been limited to Chinese isolates. aim the present study build upon these an extended panel international Methods Genomes from Asia (1972...
The aim of this study was to examine the risk factors for pharyngeal carriage meningococci in third-level students using an unsupervised machine learning approach. Data were gathered as part meningococcal prevalence studies conducted by Irish Meningitis and Sepsis Reference Laboratory (IMSRL). Pharyngeal swab cultures taken from each student once they had completed a single-page anonymous questionnaire addressing basic demographics, social behaviors, living arrangements, vaccination,...
Summary Background The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis and agalactiae . Here we analyse incidence distribution disease during first two years pandemic. Methods Laboratories in 30 countries/territories representing five continents submitted case data from 2018-2021 private projects within databases...