A5056870639- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Legionella and Acanthamoeba research
- Infective Endocarditis Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial biofilms and quorum sensing
- Virology and Viral Diseases
- Tracheal and airway disorders
- Respiratory viral infections research
- Influenza Virus Research Studies
- Rabies epidemiology and control
- Microbial infections and disease research
- Nerve injury and regeneration
- Infectious Diseases and Tuberculosis
- Amoebic Infections and Treatments
- Neurobiology of Language and Bilingualism
- Orthopedic Infections and Treatments
- Language Development and Disorders
- Antibiotic Resistance in Bacteria
- Electrospun Nanofibers in Biomedical Applications
- Enterobacteriaceae and Cronobacter Research
- Congenital Ear and Nasal Anomalies
- Antifungal resistance and susceptibility
- Infections and bacterial resistance
- Actinomycetales infections and treatment
National Institute of Health Dr. Ricardo Jorge
2014-2023
Hospital de Dona Estefânia
2019
Centro Hospitalar de Lisboa Central
2016-2019
National Institute of Allergy and Infectious Diseases
2019
National Institutes of Health
2016-2019
Nova Medical (United States)
2019
National Institute of Health
2019
Maine Farmland Trust
2016
United States Department of Veterans Affairs
2016
University of Iowa Hospitals and Clinics
2016
Background The total incidence of invasive meningococcal disease (IMD) in Europe has been declining recent years; however, a rising due to serogroup W (MenW), predominantly sequence type 11 (ST-11), clonal complex (cc11), was reported some European countries. Aim aim this study compile the most laboratory surveillance data on MenW IMD from several countries assess trends Europe. Methods In observational, retrospective study, collected 2013–17 by national reference laboratories and units 13...
The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage vaccine. From panel 3912 MATS-typed invasive meningococcal disease collected England and Wales 2007–2008, 2014–2015 2015–2016, 16 other countries 2000–2015, 3481 were...
<h3>Importance</h3> A 4-component meningococcus group B vaccine (4CMenB) is the only in use to prevent invasive meningococcal disease young children, but no matched controlled studies have evaluated it. <h3>Objective</h3> To determine association between receipt of 4CMenB and disease. <h3>Design, Setting, Participants</h3> Matched incidence density case-control study. Patients presenting from October 2014 March 2019 were ascertained, with follow-up until death or discharge (last June 2019)...
Neisseria meningitidis or meningococcus is divided into 12 distinct serogroups of which A, B, C, W, X, and Y are medically most important cause health problems in different parts the world. The epidemiology N. unpredictable over time across geographic regions. Globally, serogroup A has been prevalent African "meningitis belt" whereas B C have predominated Europe. In a paper published earlier this journal (1) , an increase invasive meningococcal disease (IMD) some European countries was...
Abstract A first strong evidence of person-to-person transmission Legionnaires’ Disease (LD) was recently reported. Here, we characterize the genetic backbone this case-related Legionella pneumophila strain (“PtVFX/2014”), which also caused a large outbreak LD. PtVFX/2014 is phylogenetically divergent from most worldwide studied outbreak-associated L. subspecies serogroup 1 strains. In fact, 1, but belongs to fraseri . Its genomic mosaic reveals eight horizontally transferred regions...
Acute septic arthritis (SA) still remains a challenge with significant worldwide morbidity. In recent years, Kingella kingae has emerged and treatment regimens have become shorter. We aim to analyze trends in SA etiology management identify risk factors for complications.
Neisseria meningitidis is differentiated into 12 distinct serogroups, of which A, B, C, W-135, X, and Y are medically most important represent an health problem in different parts the world. The epidemiology N. unpredictable over time across geographic regions. Recent epidemiological surveillance has indicated increase serogroup invasive meningococcal disease some Europe as shown data for 2010 from various European countries previously published this journal.Citation1 Here, reported...
Neisseria meningitidis is differentiated into 12 distinct serogroups, of which A, B, C, W, X, and Y are medically most important represent an health problem in different parts the world. The epidemiology N. unpredictable over time across geographic regions. Recent epidemiological surveillance has indicated increase serogroup invasive meningococcal disease some Europe as shown data for 2010 2011 from various European countries previously published this journal.Citation1,Citation2 Here, 33...
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defect in production of phagocyte-derived reactive oxygen species, which leads to recurrent infections with characteristic group pathogens not previously known include methylotrophs. Methylotrophs are versatile environmental bacteria that can use single-carbon organic compounds as their sole source energy; they rarely cause immunocompetent persons. We have identified 12 methylotrophs (5 reported here, 7 reported)...
Lawsonella clevelandensis is a Gram-stain-positive, partially acid-fast, anaerobic, being considered new species within genus in the suborder Corynebacterineae. There are only few cases reported worldwide. This fastidious microorganism, difficult to identify by conventional methods, leading inappropriate treatments. The authors report case of 29-year-old woman with 3-week evolution breast nodule. was family history carcinoma. Samples were collected for histological and microbiological...
We describe the investigation and control of an outbreak Legionnaires' disease in Portugal October, November December 2014. Confirmed cases were individuals with pneumonia, laboratory evidence Legionella pneumophila serogroup 1 exposure, by residence, occupational or leisure to affected municipalities. 49 possible sources reduced four potential sources, all industries wet cooling system, following risk assessment. geo-referenced cases' residences location towers defining study areas 10 km...
Objective Although the incidence of meningococcal disease has been declining over past decade in Portugal MenB meningococci is still an important cause meningitis and sepsis. The aim this study was to estimate strain coverage 4CMenB vaccine order support health policies for prevention control disease. Methods Since 2002 clinical laboratory notification mandatory Portugal. National database includes since then all confirmed cases notified reference or Directorate Health. Strains included were...
SUMMARY Neisseria meningitidis capsular switching has been reported in several countries. In order to establish the genetic relationship within group B and C strains expressing subtypes 2a or 2b, evaluate whether occurred Portugal, 64 meningococci (56 serogroup 8 B) isolated from invasive meningococcal disease were typed using molecular methods. The studied phenotypes, 2b:P1.5,2 2a:P1.5-1,10-8, most frequent among C, but uncommon strains. multi-locus sequence typing (MLST) allelic profile...
Incidence, morbidity and mortality of bacterial meningitis in developing countries are manifold greater than those the industrialized world. We reviewed retrospectively children with treated paediatric hospital Luanda 2004. Among 555 children, median age 11.0 months, leading agents were Haemophilus influenzae type b (Hib), pneumococcus, meningococcus 60%, 24%, 10%, respectively. The length illness before admission was 7 d. 65% had convulsed. Altered level consciousness observed 61% blood...
Rat-bite fever is a rarely diagnosed illness caused by Streptobacillus moniliformis . Although this disease distributed worldwide, there have been few cases reported in Europe. Here, we report case of vertebral osteomyelitis and sternoclavicular septic arthritis S. Portuguese patient previously bitten rat. Laboratory diagnosis was performed using molecular identification. This the first rat-bite Portugal. The described here serves as reminder for physicians to consider patients who developed...
(1) Background: We aim to identify clinical and laboratorial parameters distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted a paediatric hospital 2013−2020 was performed. Clinical data at admission 48 h, as well on treatment evolution, were obtained. (3) Results: found total 75 children, 44 K. 31 infections (mostly MSSA, S. pneumoniae pyogenes)....
Abstract Invasive meningococcal disease (IMD) continues to be a public health problem due its epidemic potential, affecting mostly children. We aimed present detailed description of the epidemiology IMD in Portugal, including insights into genetic diversity Neisseria meningitidis strains. Epidemiological analysis included data from Portuguese National Reference Laboratory during 2003 2020. Since 2012, N. isolates have also been assessed for their susceptibility antibiotics and were...
Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal this study was to assess the vivo histocompatibility both through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan elicited exuberant inflammatory response were consequently rejected. not rejected degree decreased gradually until third month implantation. Histological evaluation also showed...
This prospective cohort pilot study included 22 cats diagnosed with partial traumatic brachial plexus injury (PTBPI), aiming to explore the response of an early intensive neurorehabilitation protocol. protocol functional electrical stimulation (FES), locomotor treadmill training and kinesiotherapy exercises, starting at time highest probability nerve repair. The synergetic benefits this multimodal approach were based on structural protective role proteins release neurotrophic factors....
In Portugal, Neisseria meningitidis serogroup B (MenB) is the most common causing invasive meningococcal disease. To protect against MenB disease two protein based vaccines are available in 4CMenB that was licenced 2014 and included routine immunization program October 2020, bivalent rLP2086 vaccine licensed 2017. The aim of this study to predict coverage Portuguese isolates sampled between 2012 2019 evaluate diversity antigens on genomic analysis. Whole-genome sequence data from 324 were...