A5044182623- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- Muscle activation and electromyography studies
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Peripheral Nerve Disorders
- Extracellular vesicles in disease
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Bee Products Chemical Analysis
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hair Growth and Disorders
- Veterinary Orthopedics and Neurology
- Tendon Structure and Treatment
- Cancer Mechanisms and Therapy
- Laser Applications in Dentistry and Medicine
- Cancer Cells and Metastasis
- Burn Injury Management and Outcomes
- Biomedical Ethics and Regulation
Universidade do Porto
2023-2025
University of Lisbon
2024
Polytechnic Institute of Porto
2020
Polytechnic Institute of Castelo Branco
2016
Chronic wounds pose a significant health concern and their prevalence, stemming from different etiologies, is on the rise due to global aging population, posing substantial burden healthcare systems in developed countries. This work aimed develop formulate new therapeutic options form of creams dressings based honey, gellan gum hyaluronic acid, for preventing treating chronic across all stages. To address this, after formulations were developed, vitro cytocompatibility was determined....
Background/Objectives: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes this rise, placing substantial burden on healthcare systems in developed countries. This work aimed develop new therapeutic options the form of creams and dressings based honey, gellan gum, hyaluronic acid for preventing treating chronic across all stages. Methods: To address this, after formulations were...
Peripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting regeneration remain difficult obtain. This study is a preliminary step towards the future use of chitosan guide conduits combined with human dental pulp stem cells conditioned media promote regrowth in rat model sciatic damage. Preliminary...
Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well dogs and cats. The assessment of regeneration through animal models may provide information for translational research future therapeutic options can be applied mutually in veterinary human medicine, from a One Health perspective. This review offers hands-on vision the non-invasive conservative approaches to peripheral injury, focusing on role neurorehabilitation repair regeneration. injury lead...
Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis requiring complex therapeutic interventions to restore functionality. This study evaluated the pro-regenerative potential of combining neural guide conduits with secretome from olfactory mucosa mesenchymal stem cells, compared gold-standard surgical techniques, validated ovine model common peroneal injury. Recovery was assessed over 24 weeks using functional, kinematic, ultrasonographic, and...
Introduction Acute paraspinal hyperesthesia in dogs can result a combination of nociceptive and neuropathic pain, often requiring pharmacological intervention. However, non-pharmacologic approaches, such as two-channel transcutaneous electrical nerve stimulation (TENS), may also be beneficial. Evidence from human medicine suggests that conventional TENS reduces pain scores potentially decreases the need for analgesic medication. This study aimed to evaluate efficacy an adjunctive treatment...
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting osteogenic using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) hBMSCs was developed extrusion-based printing. Rheological tests performed on crosslinked...
Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well dogs and cats. The assessment of regeneration trough animal models may provide information for translational research future therapeutic options can be applied mutually in veterinary human medicine, a one health perspective. This review offers hands-on vision about the non-invasive conservative approaches on peripheral injury, focusing role neurorehabilitation repair regeneration. injury lead to...
Exosomes have shown promising potential as a therapeutic approach for wound healing. Nevertheless, the translation from experimental studies to commercially available treatments is still lacking. To assess current state of research in this field, systematic review was performed examine methodological heterogeneity among conducted over past five years. Additionally, analyzed suitability animal models used and their relevance human medicine. A PubMed search english-language, full-text papers...
Gastric cancer (GC) ranked as the fifth most incident in 2020 and third leading cause of mortality. Surgical prevention radio/chemotherapy are main approaches used GC treatment, there is an urgent need to explore discover innovative effective drugs better treat this disease. A new strategy arises with use repurposed drugs. Drug repurposing coupled drug combination schemes has been gaining interest scientific community. The objective project was evaluate therapeutic effects alternative GC....
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In the current study, we investigate use of alginate-based materials as polymeric inks for 3D bioprinting osteogenic using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) hBMSCs was developed extrusion-based printing. Rheological tests perfomed on crosslinked...
The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field regenerative medicine. This paper aims provide a comprehensive overview 3D technology therapies, highlighting results diverse medical applications, while also discussing capabilities limitations combined use. synergistic combination printing cellular been recognised as promising innovative approach, it is expected that these...
Background Current literature warrants surgical decompression in paraplegic dogs with absent pain perception (APP), but the rate of ambulatory APP following thoracolumbar (TL) IVDE surgery a clinical setting remains unknown. Furthermore, outcome French Bulldogs (FBs) is anecdotally considered poor. The aims this study were threefold within large population TL-IVDE undergoing decompressive surgery: (1) to characterize early spontaneous pelvic limb movement and ambulation surgery; (2) identify...
Background: Stem cells are capable of self-renewal and differentiation into various specialized cells, making them a potential therapeutic option in regenerative medicine. This study establishes comprehensive methodology for isolating, culturing, characterizing rat hair follicle stem cells. Methods Results: Hair follicles were harvested from Sprague–Dawley rats subjected to two different isolation techniques. Immunohistochemical analysis real-time PCR confirm the expression specific surface...
Peripheral nerve injury remains a medical challenge with no easy resolution. Over the last few decades, significant advances have been achieved in promoting peripheral regeneration, and new assessment tools developed, both functional imaging, to quantify proportion quality of recovery. The exploration animal models, larger, more complex similarities humans, has made it possible reduce gap between results obtained classic models such as rodents application therapies humans animals clinical...
This prospective observational cohort pilot study included 22 cats diagnosed with partial traumatic brachial plexus injury (PTBPI), aiming to explore responses an early intensive neurorehabilitation protocol in a clinical setting. functional electrical stimulation (FES), locomotor treadmill training and kinesiotherapy exercises, starting at the time highest probability of nerve repair. The synergetic benefits this multimodal approach were based on potential structural protective role...
Research on supervised learning algorithms in 3D scene understanding has risen prominence and witness great increases performance across several datasets. The leading force of this research is the problem autonomous driving followed by indoor segmentation. However, openly available data these tasks mainly focuses urban scenarios. In paper, we propose TS40K, a point cloud dataset that encompasses more than 40,000 Km electrical transmission systems situated European rural terrain. This not...
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting osteogenic using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nanohydroxyapatite (nHA), type I collagen (Col) hBMSCs was developed extrude-based printing. Rheological tests perfomed on crosslinked...