A5080844644- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Infectious Diseases and Mycology
- Tendon Structure and Treatment
- Mycobacterium research and diagnosis
- Periodontal Regeneration and Treatments
- Wnt/β-catenin signaling in development and cancer
- Wound Healing and Treatments
- Hedgehog Signaling Pathway Studies
- Environmental Toxicology and Ecotoxicology
- Bone Tissue Engineering Materials
- Helicobacter pylori-related gastroenterology studies
- Nerve Injury and Rehabilitation
- Gastrointestinal Tumor Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Effects and risks of endocrine disrupting chemicals
- Mesenchymal stem cell research
- Iron Metabolism and Disorders
- Barrier Structure and Function Studies
- Nerve injury and regeneration
- Veterinary Equine Medical Research
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
Universidade do Porto
2016-2025
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2020
Iuliu Hațieganu University of Medicine and Pharmacy
2020
Institute of Biomedical Science
2007-2014
While the deregulation of iron homeostasis in breast epithelial cells is acknowledged, iron-related alterations stromal inflammatory from tumor microenvironment have not been explored. Immunohistochemistry for hepcidin, ferroportin 1 (FPN1), transferrin receptor (TFR1) and ferritin (FT) was performed primary tissues axillary lymph nodes order to dissect iron-profiles cells, lymphocytes macrophages. Furthermore, carcinoma core biopsies frozen optimum cutting temperature (OCT) compound were...
Despite the progressive research and recent advances in drug therapy to treat solid tumours, number of cases deaths patients with cancer is still a major health problem. Drug repurposing coupled combination strategies has been gaining interest among scientific community. Recently, our group proposed novel combinations for breast colon using repurposed drugs from different classes (antimalarial central nervous system (CNS)) chemotherapeutic agents such as 5-fluorouracil (5-FU), paclitaxel...
Chronic wounds pose a significant health concern and their prevalence, stemming from different etiologies, is on the rise due to global aging population, posing substantial burden healthcare systems in developed countries. This work aimed develop formulate new therapeutic options form of creams dressings based honey, gellan gum hyaluronic acid, for preventing treating chronic across all stages. To address this, after formulations were developed, vitro cytocompatibility was determined....
Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis requiring complex therapeutic interventions to restore functionality. This study evaluated the pro-regenerative potential of combining neural guide conduits with secretome from olfactory mucosa mesenchymal stem cells, compared gold-standard surgical techniques, validated ovine model common peroneal injury. Recovery was assessed over 24 weeks using functional, kinematic, ultrasonographic, and...
Background/Objectives: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes this rise, placing substantial burden on healthcare systems in developed countries. This work aimed develop new therapeutic options the form of creams and dressings based honey, gellan gum, hyaluronic acid for preventing treating chronic across all stages. Methods: To address this, after formulations were...
Abstract Background Cutaneous mast cell tumours are one of the most common neoplasms in dogs and show a highly variable biologic behaviour. Several prognosis tools have been proposed for canine tumours, including histological grading proliferation markers. CD117 is receptor tyrosine kinase thought to play key role human neoplasms. Normal (membrane-associated) aberrant (cytoplasmic, focal or diffuse) immunoexpression patterns identified tumours. Cytoplasmic expression has found correlate with...
Skeletal muscle has good regenerative capacity, but the extent of injury and developed fibrosis might prevent complete regeneration. The in vivo application human mesenchymal stem cells (HMSCs) umbilical cord conditioned media (CM) where HMSCs were cultured expanded, associated with different vehicles to induce regeneration, was evaluated a rat myectomy model. Two commercially available spherical hydrogel by our research group used. treated groups obtained interesting results terms both...
Tendon and ligament injuries are frequent in sport horses humans, such represent a significant therapeutic challenge. Tissue regeneration function recovery the paramount goals of tendon lesion management. Nowadays, several regenerative treatments being developed, based on use stem cell cell-based therapies. In present study, preparation equine synovial membrane mesenchymal cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization,...
Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge overcome. This impels regenerative medicine develop innovative therapies that enhance regeneration, retrieving original properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used therapeutic products, they secrete variety bioactive molecules play pivotal role regeneration. These factors released...
The persistent organic pollutant p,p'-DDE, the major metabolite of insecticide DDT, has displayed evidence endocrine disruption through inhibition androgen binding to receptors in different species. Although p,p'-DDE was continuously detected wild fish with abnormal gonad development such as intersex, little is known about its mode action during fish. To elucidate potential effects this zebrafish (Danio rerio), juveniles (30 days post hatch) were exposed critical window sexual...
Summary In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number for synaptophysin; a single tumour was S100. Staining Ki‐67 occurred in 18 cases; Ki‐67‐labelling index intensity immunostaining increased more pleomorphic malignant tumours, as assessed on histological grounds. Immunohistochemistry did not aid recognition less well‐differentiated tumours.
Stem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair damaged or dysfunctional tissues organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded promising tool in because their several favorable properties such multipotency, high proliferation rate, helpful location, few associated ethical issues. These easily accessible nasal cavity most mammals, including rat, can be applied autologous treatments, do...
Abstract Background Ovine pulmonary adenocarcinoma (OPA) is a neoplastic disease caused by exogenous Jaagsiekte Sheep Retrovirus (exJSRV). The prevalence of JSRV-related OPA in Eastern European countries, including Romania unknown. We aimed to investigate: the and morphological features (classical atypical forms) Transylvania region (Romania), immunophenotype tumors their relationships with exJSRV infection. A total 2693 adult ewes slaughtered between 2017 2019 two private slaughterhouses...
Endometrial adenocarcinomas are a rare type of tumour in cats. Though different morphologies have been reported, the most frequent histological feline endometrial adenocarcinoma (FEA) is papillary serous. Characterization molecular markers expression FEA may contribute to clarify pathogenesis these tumours and assess differences between normal endometrium regarding pattern several proteins. Therefore, this study aimed evaluate immunohistochemical profile wide panel antibodies (specific for...
Background/Aim: Peripheral nerve sheath tumors (PNSTs) belong to a very heterogeneous group of neoplasms occurring both in dogs and humans. The aim the present study was evaluate histological immunohistochemical features canine cutaneous PNSTs contributing further refine their diagnosis. Materials Methods: histopathological phenotype biological behavior 40 were evaluated vimentin, S-100, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), desmin, alpha-smooth muscle actin...
Gastric cancer (GC) ranked as the fifth most incident in 2020 and third leading cause of mortality. Surgical prevention radio/chemotherapy are main approaches used GC treatment, there is an urgent need to explore discover innovative effective drugs better treat this disease. A new strategy arises with use repurposed drugs. Drug repurposing coupled drug combination schemes has been gaining interest scientific community. The objective project was evaluate therapeutic effects alternative GC....