A5048895983- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Reproductive tract infections research
- Biosensors and Analytical Detection
- Head and Neck Surgical Oncology
- Immunodeficiency and Autoimmune Disorders
- Indoor Air Quality and Microbial Exposure
- Parasitic infections in humans and animals
- Influenza Virus Research Studies
- Antibiotic Use and Resistance
- Head and Neck Anomalies
- Infection Control and Ventilation
- Streptococcal Infections and Treatments
- Virology and Viral Diseases
- Microbial Inactivation Methods
- Radiopharmaceutical Chemistry and Applications
Narodowy Instytut Leków
2015-2025
Centrum Badań Jakości
2006-2007
Background The total incidence of invasive meningococcal disease (IMD) in Europe has been declining recent years; however, a rising due to serogroup W (MenW), predominantly sequence type 11 (ST-11), clonal complex (cc11), was reported some European countries. Aim aim this study compile the most laboratory surveillance data on MenW IMD from several countries assess trends Europe. Methods In observational, retrospective study, collected 2013–17 by national reference laboratories and units 13...
The epidemiology of invasive listeriosis in humans appears to be weakly characterized Poland, the sixth most populous member state European Union. We obtained antimicrobial susceptibility data, PCR-serogroups and genotypic profiles for 344 isolates Listeria monocytogenes, collected between 1997 2013 Poland. All were susceptible 10 tested antimicrobials, except one that was resistant tetracycline minocycline harbored tet(M), tet(A) tet(C) genes. Overall, no increasing MIC values observed...
ABSTRACT Identification of clinical isolates Neisseria meningitidis that are resistant to rifampin is important avoid prophylaxis failure in contacts patients, but it hindered by the absence a breakpoint for resistance, despite many efforts toward standardization. We examined large number ( n = 392) meningococcal isolates, spanning 25 years (1984 2009), were collected 11 European countries, Argentina, and Central African Republic. The collection comprises all with MICs ≥0.25 mg/liter 161)...
Background Neisseria meningitidis is a leading etiologic agent of severe invasive disease. The objective the study was to characterise meningococcal disease (IMD) epidemiology in Poland during last decade, based on laboratory confirmed cases. Methods encompassed all meningococci collected between 2002 and 2011 National Reference Centre for Bacterial Meningitis. isolates were re-identified characterised by susceptibility testing, MLST analysis, porA fetA sequencing. A PCR technique used...
Rapid identification of SARS-CoV-2 variants is essential for epidemiological surveillance. RT-qPCR-based variant differentiation tests can be used to quickly screen large sets samples relevant concern/interest; this study was conducted on specimens collected at 11 centers located in Poland during routine diagnostics between August 2020 and December 2021. A total 1096 (with CT < 30) were screened Alpha, Beta, Delta, Kappa Omicron using commercial assays targeting repeat mutation sites....
One of the tools to contain SARS-CoV-2 pandemic was increase number performed tests and improve access diagnostics. To this effect, mobile collection sites (MCSs) were established. This study on samples collected at MCS between November 2020 March 2021. We aimed confirm/exclude SARS-CoV-2, differentiate variants, detect other respiratory pathogens. viruses identified by RT-qPCRs. A total 876 (46.35%) positive specimens in diagnostic identified. The wild-type variant determined 667 (76.14%)...
Accurate and rapid identification of COVID-19 is critical for effective patient treatment disease outcomes, as well the prevention SARS-CoV-2 transmission. Rapid antigen tests (RATs) identifying are simpler, faster less expensive than molecular assays. Any new product to be considered a medical device subject evaluation data analysis verify in vitro diagnostic ability achieve its intended purpose. Clinical validation such test prerequisite before clinical application. This study was on adult...
COVID-19 was initially reported in China at the end of 2019 and soon thereafter, March 2020, WHO declared it a pandemic. Until October 2021, over 240 million cases were recorded, with 4.9 mln deaths. In order to stop spread this disease, is crucial monitor detect any infected person. The etiologic agent novel coronavirus called SARS-CoV-2. gold standard for detection virus RT-qPCR method. This study evaluated two RNA extraction methods four commercial assays routinely used diagnostic...
On 5 January 2007, two soldiers from a military base in Warsaw, Poland, presented with symptoms indicating fulminant sepsis. The were admitted to intensive care units different hospitals. Neisseria meningitidis was isolated blood and cerebrospinal fluid the case of one patient only other, sent National Reference Centre for Bacterial Meningitis (NRCBM) further characterisation.
Streptococcus pyogenes (group A Streptococcus, GAS) is a major human pathogen and causes every year over 600 millions upper respiratory tract onfections worldwide. Untreated or repeated infections may lead to post-infectional sequelae such as rheumatic heart disease, cause of GAS-mediated mortality. There no comprehensive, longitudinal analysis the M type distribution strains isolated in Poland. Single reports describe rather their antibiotic resistance patterns focus on invasive isolates....
Neisseria meningitidis serogroup B (MenB) has recently become the major cause of invasive meningococcal disease in Poland. Therefore, purpose this study was to characterize MenB isolates, responsible for 2010–2016, by MLST and sequencing genes encoding proteins used as 4CMenB vaccine antigens. Two methods coverage estimation were performed: extrapolation MATS results Polish meningococci 2010–2011 (exMATS) gMATS, which combines genotyping results. Among 662 isolates 20 clonal complexes (CC)...
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This study evaluated the usefulness of Pneumotest-Latex assay for serotyping Streptococcus pneumoniae isolates directly in clinical samples. With an agreement 88.1% with a PCR-based reference method, this test can be useful tool purpose, especially laboratories that do not have access to nucleic acid amplification technologies.
The aim of this study was to describe the characteristics invasive meningococcal disease (IMD) among patients under 20 years age in Poland from 2009 2011, based on data collected by National Reference Centre for Bacterial Meningitis (NRCBM). performed all Neisseria meningitidis Poland, between and 2011 NRCBM. isolates were identified serotyped. MICs determined Etests or M.I.C.Evaluators. A PCR technique used identification etiological agent directly clinical materials case a negative...