A5044896571- SARS-CoV-2 and COVID-19 Research
- Diphtheria, Corynebacterium, and Tetanus
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- Receptor Mechanisms and Signaling
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Intramuscular injections and effects
- Dental Anxiety and Anesthesia Techniques
- Neurological disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Dermatological and COVID-19 studies
- Enterobacteriaceae and Cronobacter Research
- Medical and Biological Ozone Research
- Computational Drug Discovery Methods
- Otolaryngology and Infectious Diseases
- Reproductive tract infections research
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Pharmaceutical and Antibiotic Environmental Impacts
Narodowy Instytut Leków
2011-2024
National Institute of Public Health
2004-2005
Central Forensic Laboratory of the Police
2000-2001
Centralne Laboratorium Kryminalistyczne Policji
2000
Rapid identification of SARS-CoV-2 variants is essential for epidemiological surveillance. RT-qPCR-based variant differentiation tests can be used to quickly screen large sets samples relevant concern/interest; this study was conducted on specimens collected at 11 centers located in Poland during routine diagnostics between August 2020 and December 2021. A total 1096 (with CT < 30) were screened Alpha, Beta, Delta, Kappa Omicron using commercial assays targeting repeat mutation sites....
One of the tools to contain SARS-CoV-2 pandemic was increase number performed tests and improve access diagnostics. To this effect, mobile collection sites (MCSs) were established. This study on samples collected at MCS between November 2020 March 2021. We aimed confirm/exclude SARS-CoV-2, differentiate variants, detect other respiratory pathogens. viruses identified by RT-qPCRs. A total 876 (46.35%) positive specimens in diagnostic identified. The wild-type variant determined 667 (76.14%)...
Accurate and rapid identification of COVID-19 is critical for effective patient treatment disease outcomes, as well the prevention SARS-CoV-2 transmission. Rapid antigen tests (RATs) identifying are simpler, faster less expensive than molecular assays. Any new product to be considered a medical device subject evaluation data analysis verify in vitro diagnostic ability achieve its intended purpose. Clinical validation such test prerequisite before clinical application. This study was on adult...
Seventeen extended-spectrum beta-lactamase (ESBL)-producing isolates of the family Enterobacteriaceae recovered from 1998 to 2000 in hospitals five different cities Poland were analyzed. They expressed several TEM-type ESBLs, TEM-4, TEM-29, TEM-85, TEM-86, TEM-93, and TEM-94. TEM-85 (L21F, R164S, E240K, T265M), TEM-86 A237T, TEM-93 (M182T, G238S, E240K), TEM-94 E104K, M182T, T265M) identified for first time. Including enzymes described earlier, TEM-47, TEM-48, TEM-49, TEM-68, group known...
The introduction of effective vaccines against SARS-CoV-2 is expected to prevent COVID-19. However, sporadic cases infection in vaccinated persons have been reported. We describe a case double-dose woman with All stages were observed, from no identification virus, then the start infection, high viral load, coming out viraemia, and finally detection virus. Despite demonstrated mild COVID-19 symptoms, manifested only by sore throat. antibody results showed that she produced both...
COVID-19 was initially reported in China at the end of 2019 and soon thereafter, March 2020, WHO declared it a pandemic. Until October 2021, over 240 million cases were recorded, with 4.9 mln deaths. In order to stop spread this disease, is crucial monitor detect any infected person. The etiologic agent novel coronavirus called SARS-CoV-2. gold standard for detection virus RT-qPCR method. This study evaluated two RNA extraction methods four commercial assays routinely used diagnostic...
Streptococcus pyogenes (group A Streptococcus, GAS) is a major human pathogen and causes every year over 600 millions upper respiratory tract onfections worldwide. Untreated or repeated infections may lead to post-infectional sequelae such as rheumatic heart disease, cause of GAS-mediated mortality. There no comprehensive, longitudinal analysis the M type distribution strains isolated in Poland. Single reports describe rather their antibiotic resistance patterns focus on invasive isolates....
The degree of seroprotection against diphtheria in Poland was evaluated by determination IgG antibodies to Corymebacterium diphtheriae toxin (IgG-DTAb). study population consisted 4,829 healthy subjects aged from 1 day 85 years 7 regions Poland. Serum samples collected between 1996 and 1998 were assayed for IgG-DTAb using a toxoid enzyme immunoassay. Neutralization Vero cells performed as reference method with the WHO standard human antitoxin. revealed lack (IgG-DTAb < 0.1 IU/ml) 23%...
Background: Vaccination is one of the most effective life-saving medical interventions, and introduction SARS-CoV-2 vaccines was intended to prevent serious implications COVID-19. The objectives study were: i) observe humoral immune response BNT162b2 vaccine infection (mainly breakthrough infections), ii) demonstrate persistence anti-SARS-CoV-2 antibodies over time in relation number received doses course infection, iii) determine adverse effects after primary doses. Methods: To assess...
Vaccination is one of the most effective life-saving medical interventions, and introduction SARS-CoV-2 vaccines was intended to prevent serious implications COVID-19. The objectives study were (i) observe humoral immune response BNT162b2 vaccine infection (mainly breakthrough infections), (ii) demonstrate persistence anti-SARS-CoV-2 antibodies over time in relation number received doses course infection, (iii) determine adverse effects after primary doses. To assess response, IgG IgA...
The cytotoxic activity of several serotonin transporter (SERT) inhibitors and subtype receptor 1A (5-HT1A receptor) ligands have been examined in androgen-insensitive human PC-3 prostate neuroblastoma SH-SY5Y cancer cells. Almost all the studied compounds (except 5-HT1A agonist (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT)) exhibited absolute against compound 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride (S14506) that...
It has been reported that the prevalance of parkinsonism might be associated with exposure to whooping cough.Examination levels antibodies against Bordetella pertussis in serum using enzyme-linked immunosorbent assay (ELISA) tests [presence IgG filamentous hemagglutinin and toxin (PT)] were performed 81 persons (including 45 patients controls) (age-matched groups).Positive results found Parkinson's disease (PD), other non-inflammatory diseases, controls (about 40-45% each group). A detailed...
Background: Vaccination is one of the most effective medical interventions to prevent infectious diseases. The introduction vaccines against coronavirus acute respiratory syndrome 2 (SARS-CoV-2) was aimed at preventing severe illness and death due disease 2019 (COVID-19). Solid organ transplant recipients (SOTRs) are high risk infection with SARS-CoV-2 serious effects associated COVID-19, mainly use immunosuppressive therapies, which further cause suboptimal response COVID-19 vaccination....