A5005682063- Immunodeficiency and Autoimmune Disorders
- Vector-borne infectious diseases
- Inflammatory Bowel Disease
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Viral Infections and Vectors
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Animal Disease Management and Epidemiology
- Microscopic Colitis
- Mosquito-borne diseases and control
- Chronic Lymphocytic Leukemia Research
- Vector-Borne Animal Diseases
- Cystic Fibrosis Research Advances
- Yersinia bacterium, plague, ectoparasites research
- Pancreatitis Pathology and Treatment
- Abdominal Trauma and Injuries
- Diverticular Disease and Complications
- Congenital Anomalies and Fetal Surgery
- Research on Leishmaniasis Studies
- Congenital Diaphragmatic Hernia Studies
- Congenital Ear and Nasal Anomalies
- Monoclonal and Polyclonal Antibodies Research
- Zoonotic diseases and public health
- Study of Mite Species
Statens Serum Institut
2011-2020
Inflammatory bowel disease (IBD), Crohn's (CD), and ulcerative colitis (UC) are chronic diseases characterized by an inappropriate immune response, which may also increase the risk of infections. We investigated invasive pneumococcal (IPD) before after diagnosis IBD in a population-based cohort study.In 74,156 patients 1,482,363 non-IBD controls included followed during 1977-2013, hazard rate ratios (HRs) for IPD vs. were calculated Cox regression. Within group, we according to ever use...
Q fever caused by Coxiella burnetii is transmitted to humans inhalation of aerosols from animal birth products. in pregnancy suspected be a potential cause fetal and maternal morbidity mortality but the pathogenesis poorly understood, even endemic areas, magnitude association not established.We aimed examine if presence antibodies C. during or seroconversion were associated with adverse outcomes.The Danish National Birth Cohort collected blood samples interview data 100,418 pregnant women...
Objective. To evaluate the initial serological responses to pneumococcal vaccination with 13-valent protein-conjugated vaccine (PCV13) followed by 23-valent polysaccharide (PPV23) among patients rheumatoid arthritis (RA) treated biological disease-modifying antirheumatic drugs (bDMARD) according dosing and intervals between immunizations. Methods. Investigator-initiated clinical trial. Patients RA receiving bDMARD were randomized (1:1:1) immunization single dose PCV13 PPV23 after 16 or 24...
Background: Serotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a WHO standardized ELISA are the gold standard for diagnosis of specific deficiency (SAD). The American Academy Allergy, Asthma and Immunulogy (AAAAI) has proposed guidelines interpret PPV response measured ELISA, but these based on limited evidence. Additionally, is costly labor-intensive. Measurement Salmonella typhi (S. typhi) Vi serum allohaemagglutinins (AHA) have been...
Background and Aims Q fever is a bacterial zoonosis caused by infection with Coxiella burnetii. It well established that causes fetal loss in small ruminants. The suspicion has been raised pregnant women may also experience adverse pregnancy outcome when the acquired or reactivated during pregnancy. purpose of this study was to assess potential association between serologic markers C.burnetii spontaneous abortion. Methods A nested case-control within Danish National Birth Cohort, cohort...
Q fever is a zoonotic infection which can pose danger to pregnant women. To our knowledge, Denmark has never experienced clinically verified outbreak. We aimed quantify risk of in women occupationally and environmentally exposed Coxiella burnetii. The Danish National Birth Cohort collected blood samples from 100,418 the period 1996 2002. sampled 195 with occupational exposure livestock (veterinarians female farmers), 202 domestic (dairy cattle and/or sheep) random sample 459 unexposed...
Vaccines may have non-specific effects. An observational study from Guinea-Bissau suggested that oral polio vaccine at birth (OPV0) provided with Bacillus Calmette-Guérin (BCG) was associated down-regulation of the immune response to BCG 6 weeks later. Based on previous finding, we wanted test our a priori hypothesis OPV would dampen BCG, and secondarily responses other antigens.The conducted Bandim Health Project in 2009-2010. Infants were randomised OPV0+BCG versus alone birth,...
Background: Q fever is a zoonosis caused by Coxiella burnetii. The disease emerging in many parts of the world, likely part due to increased awareness and availability better diagnostic tests. clinical diagnosis difficult, most confirmed cases rely on serology. Methods: This study compared sensitivity, specificity, performance 2 commercial enzyme-linked immunosorbent assay (ELISA) kits, with microimmunofluorescence antibody test (IFA) used as reference. Results: One ELISA kits showed higher...
Background: Patients suffering from Crohn's disease (CD) are at increased risk of infectious diseases, such as pneumococcal infection. The increases with immunotherapy. Pneumococcal infection can be prevented by vaccination. Methods: We conducted a randomized trial the 23-valent polysaccharide vaccine (PPV23) and 13-valent conjugated (PCV13) in groups CD patients treated immunosuppressive (IS) drugs form thiopurines (PPV23 n = 28, PCV13 28) alone or combination TNF-α antagonists 13, 13) not...
BackgroundThe aim of this study was to determine antibody titres against Campylobacter, Salmonella, and Yersinia in a population-based cohort pregnant women Denmark order evaluate adverse pregnancy outcomes (miscarriage, preterm birth, small for gestational age) relation occupational exposure animals exposed food producing animals.MethodsWe used data blood samples from the Danish National Birth Cohort. Serum collected during first trimester 192 who were occupationally domestic 188 randomly...
The risk of life-threatening and invasive infections with encapsulated bacteria is increased in patients hyposplenia or asplenia. We report a case recurrent pneumococcal meningitis woman previous unknown hyposplenia. She was vaccinated after the first episode developed sufficient levels antibodies. strains isolated were serotype 7 F 17 F. To our knowledge, there has been no previously reported disease adult apparently antibody response. course 38-year-old Caucasian presenting episodes (IPD)...
Background. Human immunodeficiency virus (HIV)–infected individuals are at increased risk of invasive pneumococcal disease (IPD). In order to assess the immunogenicity proteins and polysaccharide, we investigated protein serotype-specific antibody responses after HIV-associated IPD.
Some children are prone to recurrent invasive pneumococcal disease (rIPD) and of these, some respond insufficiently standard vaccination. Little is known about how handle these if they benefit from additional Here, we present results a nationwide study pediatric rIPD including data on serotype-specific vaccination response polysaccharide (PPV23) conjugate (PCV7/13). A retrospective, population-based was conducted using The National Streptococcus pneumoniae Registry, which contains...
This is the first case report of recurrent invasive pneumococcal disease (IPD), specifically, due to serotype 12F. The patient described here was vaccinated with 23-valent polysaccharide vaccine (PPV23) previous splenectomy, and an anti-pneumococcal IgG test concluded that she had responded sufficiently vaccination. Still, a fulminate infection PPV23 We investigated test, it turned out based on geometric mean value only 12 serotypes included in PPV23; 12F none them. reason there are no titer...
Serology of Streptococcus pneumoniae is challenging due to existence multiple clinically relevant serotypes and the introduction multivalent vaccines in national immunization programs. Multiplex immunoassays (MIAs) are applied as high-throughput cost-effective methods for serosurveillance, yet laboratories use their own protocols. The aims this study were assess agreement results generated by MIAs different within EU Pneumo Assay Consortium, analyze factors contributing differences outcome,...
Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks Scandinavia are reported to be infected with Rickettsia, yet only few Scandinavian human cases described, and rickettsiosis poorly understood. The aim of this study was determine prevalence Denmark based on laboratory findings. We found that Danish individuals who tested positive for Rickettsia serology, majority (86%; 484/561) infections belonged spotted fever group. In contrast, we could...