A5039399560- Immune responses and vaccinations
- Antimicrobial Resistance in Staphylococcus
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Virology and Viral Diseases
- Parasitic Diseases Research and Treatment
- Infant Development and Preterm Care
- Vaccine Coverage and Hesitancy
- Antioxidant Activity and Oxidative Stress
- Infections and bacterial resistance
- Ear and Head Tumors
- Bacillus and Francisella bacterial research
- Marine Bivalve and Aquaculture Studies
- Drug-Induced Adverse Reactions
- Plant Pathogenic Bacteria Studies
- Respiratory and Cough-Related Research
- Fatty Acid Research and Health
- Ear Surgery and Otitis Media
- Global Maternal and Child Health
- Bacterial Identification and Susceptibility Testing
Gentofte Hospital
2021-2024
Copenhagen University Hospital
2014-2024
Statens Serum Institut
2014-2017
Bandim Health Project
2013-2017
Hvidovre Hospital
2015
BCG vaccine may reduce overall mortality by increasing resistance to nontuberculosis infections. In 2 randomized trials in Guinea-Bissau of early BCG-Denmark (Statens Serum Institut) given low-weight (LW) neonates (<2500 g at inclusion) infant rates, we observed a very beneficial effect the neonatal period. We therefore conducted present trial test whether reduces 45%. also meta-analysis 3 trials. 2008–2013, LW "early BCG-Denmark" (intervention group; n = 2083) or "control" (local policy for...
Background. Bacillus Calmette–Guérin (BCG) seems to have beneficial nonspecific effects; early BCG vaccination of low-birth-weight (LBW) newborns reduces neonatal mortality by >40% due prevention primarily septicemia and pneumonia. Methods. Within a randomized trial in LBW infants Guinea-Bissau vs the usual postponed BCG, subgroup was bled 4 weeks after randomization. Levels interleukin (IL)-1β, IL-5, IL-6, IL-10, IL-17, interferon (IFN)-γ tumor necrosis factor (TNF)-α were measured from...
In a hospital-acquired infection with multidrug-resistant Elizabethkingia, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene analysis identified the pathogen as Elizabethkingia miricola. Whole-genome sequencing, genus-level core genome analysis, in silico DNA-DNA hybridization of 35 strains indicated that species taxonomy should be further explored.
Vaccines may have non-specific effects. An observational study from Guinea-Bissau suggested that oral polio vaccine at birth (OPV0) provided with Bacillus Calmette-Guérin (BCG) was associated down-regulation of the immune response to BCG 6 weeks later. Based on previous finding, we wanted test our a priori hypothesis OPV would dampen BCG, and secondarily responses other antigens.The conducted Bandim Health Project in 2009-2010. Infants were randomised OPV0+BCG versus alone birth,...
The World Health Organization recommends high-dose vitamin A supplementation (VAS) for children above six months of age in low-income countries. VAS has been associated with up-regulation the Th2 response. We aimed to determine if is atopy childhood.Infants Guinea-Bissau were randomly allocated or placebo, either at and nine age, only age. At furthermore randomized measles vaccine inactivated polio vaccine. all received Children revisited seven years later skin prick testing was performed....
Decolonization treatment of MRSA carriers is recommended in Denmark, except households with MRSA-positive children <2 years old (wait-and-see approach).
External otitis (EO) is a common and often painful infection in the ear canal. This review provides an overview of typical presentation, causes, complications, treatment EO. The condition influenced by factors like pH levels, inflammation, bacterial or fungal invasion. Most bacteria involved are Pseudomonas aeruginosa Staphylococcus aureus, most fungi Aspergillus Candida species. EO can lead to serious such as necrotising EO, which requires prompt medical attention. Treatment involves local...
Throat carriage of methicillin-resistant
Abstract Background Staphylococcus aureus is a frequent colonizer of the human skin and mucous membranes but can also cause variety serious infections. Antimicrobial resistance an increasing worldwide challenge mainly driven by overuse antimicrobials . To avoid spread methicillin-resistant (MRSA) in Denmark, Danish Health Authority recommends decolonization treatment MRSA carriers their household contacts. Standard includes chlorhexidine body wash mupirocin nasal ointment, especially throat...
Introduction For Streptococcus pneumoniae , β-lactam susceptibility can be predicted from the amino acid sequence of penicillin-binding proteins PBP1a, PBP2b, and PBP2x. The combination PBP-subtypes provides a PBP-profile, which correlates to phenotypic minimal inhibitory concentration (MIC). non- S. Mitis-group streptococci (MGS) have similar PBPs exchange pbp -alleles with . We studied whether simple BLAST analysis could used predict in Danish isolates internationally collected MGS. Method...