A5025579186- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Appendicitis Diagnosis and Management
- Streptococcal Infections and Treatments
- Patient Satisfaction in Healthcare
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Diverticular Disease and Complications
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- Neonatal and Maternal Infections
- T-cell and B-cell Immunology
- Historical Medical Research and Treatments
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Intraperitoneal and Appendiceal Malignancies
- Pneumonia and Respiratory Infections
University of Copenhagen
2012-2025
Gentofte Hospital
2017-2025
Copenhagen University Hospital
2010-2023
Herlev Hospital
2012-2023
Slagelse Hospital
2015-2020
Region Zealand
2020
Statens Serum Institut
2015
National University Hospital of Iceland
2010
Hvidovre Hospital
2010
Landesamt für Umwelt, Naturschutz und Geologie
2010
ObjectivesIn Denmark, the incidence of vancomycin-resistant Enterococcus faecium (VREfm) has increased since 2012. The aim this study was to investigate epidemiology and clonal relatedness VREfm isolates in Danish hospitals 2012–13 using WGS. second evaluate if WGS-based typing could replace PFGE for VREfm.
Background Vancomycin-resistant enterococci (VRE) are increasing in Denmark and Europe. Linezolid vancomycin-resistant (LVRE) of concern, as treatment options limited. Vancomycin-variable (VVE) harbour the vanA gene complex but phenotypically vancomycin-susceptible. Aim The aim was to describe clonal shifts for VRE VVE between 2015 2022 investigate genotypic linezolid resistance among VVE. Methods From 2022, 4,090 Danish clinical isolates were whole genome sequenced. We extracted vancomycin...
In enterococci, resistance to linezolid is often mediated by mutations in the V domain of 23S rRNA gene (G2576T or G2505A). Furthermore, four genes [optrA, cfr, cfr(B) and poxtA] encode enterococci. We aimed develop a Web tool for detection two encoding enterococci from whole-genome sequence data. LRE-Finder (where LRE stands linezolid-resistant enterococci) detected fraction Ts position 2576 As 2505 cfr(B), optrA poxtA aligning raw sequencing reads (fastq format) with k-mer alignment. For...
To describe the changing epidemiology of vancomycin-resistant Enterococcus faecium and faecalis in clinical samples Denmark 2005-15 according to species van type, and, furthermore, investigate genetic relatedness E. isolates from 2015.During 2005-14, all VRE were tested for presence vanA/B/C genes by PCR. In 2015, whole-genome sequenced. From WGS data, MLST STs extracted silico . Core-genome (cgMLST) analysis was performed isolates.During 2005-15, 1043 vanA , 25 vanB 4 28 detected. The...
We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained patients Denmark 2015 to the first quarter (Q1) of 2019. During Q1 2019, vancomycin-variable enterococci (VVE) ST1421-CT1134 E. became most dominant clone and has spread all five regions Denmark. Among 174 with vanA, vanB or vanA/vanB genes 44% belonged this type.
This study aimed to characterise carbapenemase-producing Acinetobacter baumannii (A. baumannii) isolates from Danish patients using whole genome sequencing (WGS). It also compared typing and epidemiological data for further investigation of the spread origin A. isolates. From 1 January 2014 30 September 2021, 141 isolates, received at national reference laboratory Statens Serum Institut, were investigated WGS. Multilocus sequence (MLST) cgMLST data, obtained by SeqSphere+ software, linked...
The emergence of bloodstream infections (BSI) caused by vancomycin-resistant Enterococci (VRE) has concern. Nonetheless, it remains unclear whether these types are associated with an excess risk severe outcomes when compared vancomycin-susceptible (VSE). This cohort study included hospitalized patients in Denmark
Background. Norovirus (NoV) is a major cause of gastroenteritis and hospital outbreaks, leading to substantial morbidity direct healthcare expenses as well indirect societal costs. The aim the study was estimate proportion nosocomial NoV infections among inpatients testing positive for in Denmark, 2002–2010, distribution genotypes with community-acquired infections, respectively. Methods. Admission stool sampling dates from 3656 NoV-infected patients were used infections. associations...
Background Carbapenemase-producing Escherichia coli are increasing worldwide. In recent years, an increase in OXA-244-producing E. isolates has been seen the national surveillance of carbapenemase-producing organisms Denmark. Aim Molecular characterisation and epidemiological investigation from January 2016 to August 2019. Methods For investigation, data Danish National Patient Registry register civil registration were used together with phone interviews patients. Isolates characterised by...
The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) is continuously changing. Iceland has a low incidence MRSA. A "search and destroy" policy (screening patients with defined risk factors attempting eradication in carriers) been implemented since 1991. Clinical microbiological data all MRSA from the years 2000 to 2008 were collected prospectively. Isolates characterized by pulsed-field gel electrophoresis (PFGE), sequencing repeat region protein gene (spa typing),...
ABSTRACT The diversity of OXA-48-like carbapenemases is continually expanding. In this study, we describe the dissemination and characteristics a novel carbapenem-hydrolyzing class D β-lactamase (CHDL) named OXA-436. total, six OXA-436-producing Enterobacteriaceae isolates, including Enterobacter asburiae ( n = 3), Citrobacter freundii 2), Klebsiella pneumoniae 1), were identified in four patients period between September 2013 April 2015. All three species found one patient. amino acid...
Vancomycin-resistant enterococci (VRE) are increasingly important nosocomial pathogens and screening for colonization status is a mainstay in infection control. We implemented PCR-based during
Norovirus (NoV) is a leading cause of gastroenteritis and genotype II.4 (GII.4) responsible for the majority nosocomial NoV infections. Our objective was to examine whether sequencing capsid gene might be useful tool hospital outbreak investigation define possible transmission routes. All positive samples submitted from one university during 2007/8 season were selected. Genotyping selected by partial polymerase had shown that belonged GII.4 variant Den Haag 2006b identical sequences....
Decolonization treatment of MRSA carriers is recommended in Denmark, except households with MRSA-positive children <2 years old (wait-and-see approach).
Bacteroides fragilis group species are the most frequently encountered bacteria involved in anaerobic bacteraemia and associated with high mortality rates. In 2012, we performed first national study of antimicrobial susceptibility B. from blood cultures Denmark.
We investigated whether prior use of antibiotics affects the risk mecillinam/trimethoprim/nitrofurantoin/multi-resistant Escherichia coli urinary tract infection (UTI) among elderly patients in general practice. Data on urine culture came from samples performed practice and sent to hospitals Capital Region Denmark, prescription data a nationwide database. The study population consisted with UTI episodes (n = 41,027) caused by E. that received concurrent antibiotic against 2012 2017. used...