A5053846920- Biochemical and Molecular Research
- Lichen and fungal ecology
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Microfluidic and Capillary Electrophoresis Applications
- Botany and Plant Ecology Studies
- Microfluidic and Bio-sensing Technologies
- Neonatal Health and Biochemistry
- Microbial Natural Products and Biosynthesis
- Bryophyte Studies and Records
- Marine Sponges and Natural Products
- Advanced Drug Delivery Systems
- Mass Spectrometry Techniques and Applications
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Ocular Surface and Contact Lens
- Cholinesterase and Neurodegenerative Diseases
- Advancements in Transdermal Drug Delivery
- Advanced Proteomics Techniques and Applications
- Seaweed-derived Bioactive Compounds
- Adolescent and Pediatric Healthcare
- Pesticide Residue Analysis and Safety
- Chemical Synthesis and Analysis
- Algal biology and biofuel production
- Bioactive Compounds and Antitumor Agents
University of Iceland
2015-2024
Icelandic Transport Authority
2016-2024
Arctic Research Centre
2019
deCODE Genetics (Iceland)
2004-2009
Uppsala University
1995-1999
To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants ABCG5/8 genes, key regulators intestinal sterols.We examined effects on non-high-density lipoprotein (non-HDL) (N up to 610 532) levels = 3039) CAD Iceland, Denmark, UK Biobank (105 490 cases 844 025 controls). We used genetic scores for non-HDL determine confer greater than predicted by their effect cholesterol. identified...
Proximal spinal muscular atrophy (SMA), one of the most common genetic causes infant death, results from selective loss motor neurons in cord. SMA is a consequence low levels survival neuron (SMN) protein. In humans, SMN gene duplicated; SMN1 but SMN2 remains intact. severity related to copy number SMN2. Compounds which increase expression could, therefore, be potential therapeutics for SMA. Ultrahigh-throughput screening recently identified substituted quinazolines as potent inducers. A...
Significance Statement Lack of well characterized experimental models 2,8-dihydroxyadenine nephropathy—resulting from formation crystals within renal tubules due to a rare hereditary deficiency adenine phosphoribosyltransferase in humans (or excessive load animals)—has hindered achieving better understanding underlying disease mechanisms. The authors demonstrate that crystal formation, deposition, and clearance, as the resulting tubular injury, inflammation, fibrosis, loss kidney function,...
Breast cancer (BC) is the most prevalent type of in women western countries. BC mortality has not declined despite early detection by screening, indicating need for better informed treatment decisions. Therefore, a novel noninvasive diagnostic tool would give opportunity subtype-specific and improved prospects patients. Heterogeneity tumor subtypes reflected expression levels enzymes lipid metabolism. The aim study was to investigate whether subtype defined transcriptome lipidome cell lines....
Natural products from plants have served mankind in a wide range of applications, such as medicines, perfumes, or flavoring agents. For this reason, synthesis, regulation and function plant-derived chemicals, well the evolution metabolic diversity, has attracted researchers all around world. In particular, vascular been subject to analyses due prevalent characteristics appearance, fragrance, ecological settings. contrast, bryophytes, constituting second largest group terms species number,...
Myocardial infarction and stroke are caused by blood clots forming over a ruptured or denuded atherosclerotic plaque (atherothrombosis). Production of prostaglandin E2 (PGE2) an inflamed exacerbates atherothrombosis may limit the effectiveness current therapeutics. Platelets express multiple G-protein coupled receptors, including receptors for ADP PGE2. can mobilize Ca2+ through P2Y12 receptor inhibit cAMP production, causing platelet activation aggregation. Clopidogrel (Plavix), selective...
Abstract Purpose We have developed nanoparticle γ ‐cyclodextrin dexamethasone ( D ex NP ) and dorzolamide orz eye drops that provide sustained high drug concentrations on the surface. To test these characteristics, we measured levels in tear fluid humans following drop administration. Methods Concentration of was by mass spectrometry. One instilled into one eye. Tear sampled with microcapillary pipettes at seven time‐points after instillation. Control eyes received M axidex ®...
Obesity is a complex disease resulting in several metabolic co-morbidities and increasing at epidemic rates. The marine environment an interesting resource of novel compounds particular cyanobacteria are well known for their capacity to produce secondary metabolites. In this work, we explored the potential production with relevant activities towards diseases using blend target-based, phenotypic zebrafish assays as whole small animal models. A total 46 cyanobacterial strains were grown...
Plants produce a multitude of metabolites that contribute to their fitness and survival play role in local adaptation environmental conditions. The effects variation are particularly well studied within the genus Plantago; however, previous studies have largely focused on targeting specific metabolites. Studies exploring metabolome-wide changes lacking, natural herbivory metabolomes plants growing situ remain unknown. An untargeted metabolomic approach using ultra-high-performance liquid...
Adenine phosphoribosyltransferase deficiency (APRT) is an uncommon, hereditary disorder characterized by renal excretion of 2,8-dihydroxyadenine (DHA), leading to kidney stone formation and chronic disease (CKD). Treatment with a xanthine oxidoreductase (XOR) inhibitor, allopurinol or febuxostat, reduces urinary DHA slows the progression CKD. The method currently used for therapeutic monitoring APRT lacks specificity thus, more reliable measurement technique needed. In this study, ultra...
Taxa in the genus Melanelia (Parmeliaceae, Ascomycota) belong to a group of saxicolous lichens with brown black foliose thalli, which have recently undergone extensive changes circumscription. belonging Parmeliaceae are prolific producers bioactive compounds, also been traditionally used for chemotaxonomic purposes. However, chemical diversity and use data species discrimination this largely unexplored. In addition, identification based on morphological characters is challenging due few...