A5071996859- Systemic Lupus Erythematosus Research
- SARS-CoV-2 detection and testing
- Salivary Gland Disorders and Functions
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Cytomegalovirus and herpesvirus research
- Lipoproteins and Cardiovascular Health
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Neurological disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- RNA regulation and disease
- Cardiovascular Disease and Adiposity
- Renal Transplantation Outcomes and Treatments
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Reproductive System and Pregnancy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Biosensors and Analytical Detection
Aarhus University Hospital
2013-2024
Aarhus University
2018
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to support clinical diagnosis and epidemiological investigations. Recently, large-scale detection of total antibodies (Ab), immunoglobulin G (IgG), IgM against SARS-CoV-2 antigens have been developed, but there limited data on the diagnostic accuracy these assays. This study was a Danish national collaboration evaluated 15 commercial one in-house anti-SARS-CoV-2 in 16 laboratories. Sensitivity...
Abstract Serological SARS-CoV-2 assays are needed to support clinical diagnosis and epidemiological investigations. Recently, for the large-volume detection of total antibodies (Ab) immunoglobulin (Ig) G M against antigens have been developed, but there limited data on diagnostic accuracy these assays. This study was organized as a Danish national collaboration included fifteencommercial one in-house anti-SARS-CoV-2 in sixteen laboratories. Sensitivity evaluated using 150 serum samples from...
Anti-SSA-autoantibodies are common in patients with rheumatologic disease, especially Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis. They consist of both autoantibodies towards Ro60 Ro52, the latter also known as TRIM21. TRIM21 is an intracellular protein consisting four domains; PRY/SPRY, Coiled-Coil, B-box RING. The aim this study was to establish indirect ELISA detecting full-length its domains. We expressed five constructs, created, validated protocols for...
<h3>Background:</h3> Primary biliary cholangitis (PBC) is an autoimmune liver disease with cholestasis, a risk of progression to cirrhosis and end-stage disease.<sup>1</sup> A common comorbidity the autoimmune, systemic connective tissue Sjögren's syndrome, which affects exocrine glands eyes mouth causes fatigue arthralgia. Anti-Ro52/TRIM21 autoantibodies (from now called anti-Ro52) are in syndrome (SS) but also seen PBC.<sup>2,3</sup> They targeted against intracellular receptor TRIM21,...
Abstract This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls. Autoinflammatory disorders typically involve immune mistakenly attacking body’s own cells start producing ANA. There is an increasing body evidence that immune-mediated inflammation a pathological feature linked synucleinopathies. To investigate whether...
Anti‐muscarinic type 3 receptor autoantibodies (M3R) and anti‐SSA antibodies are both related to salivary secretion. The presence of M3R in Sjögren's syndrome is previously demonstrated; nevertheless, the relationship between fragment antibodies, namely N terminal, first, second, third extracellular loops, remains be elucidated. In this study, we analyzed against epitopes healthy controls antibody‐positive connective tissue disease patients through ELISA method. Antibodies loop (M3R 211–230...