A5015557380- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- S100 Proteins and Annexins
- Folate and B Vitamins Research
- Genetic Syndromes and Imprinting
- Heart Rate Variability and Autonomic Control
- Ginkgo biloba and Cashew Applications
- Amyotrophic Lateral Sclerosis Research
- Autoimmune Neurological Disorders and Treatments
- Dye analysis and toxicity
- Biotin and Related Studies
- Renal Diseases and Glomerulopathies
- Obsessive-Compulsive Spectrum Disorders
- Cerebrovascular and genetic disorders
- Heavy Metal Exposure and Toxicity
- Plant Gene Expression Analysis
Frederiksberg Hospital
2019-2024
Copenhagen University Hospital
2011-2024
University of the Faroe Islands
2008-2022
University of Copenhagen
2009-2020
Bispebjerg Hospital
2010-2020
Universidad de la República
2001
In order to assess the relative influence of age, resting heart rate (HR) and sedentary life style, variability (HRV) was studied in two different groups. The young group (YG) consisted 9 subjects aged 15 20 years (YG-S) nonsedentary volunteers (YG-NS) also 20. elderly (ESG) 16 39 82 years. HRV assessed using a short-term procedure (5 min). R-R calculated time-domain by means root mean square successive differences. Frequency-domain evaluated power spectrum analysis considering high...
A study in The Faroe Islands 1995 suggested a high prevalence of idiopathic Parkinson's disease (IPD) and total parkinsonism 187.6 233.4 per 100,000 inhabitants respectively.Detailed case-finding methods 10 years later were used neurologist has verified the diagnosis.The crude IPD was 206.7 227.4 respectively. age-adjusted is twice as data from Norway Denmark. Age at initiation treatment fatality rate did not explain increased prevalence. During 1995-2005, average annual incidence 21.1...
Eiberg H, Hansen L, Korbo Nielsen IM, Svenstrup K, Bech S, Pinborg LH, Friberg Hjermind LE, Olsen OR, JE. Novel mutation in ATP13A2 widens the spectrum of Kufor‐Rakeb syndrome (PARK9). (KRS) is a rare autosomal recessive inherited juvenile parkinsonian caused by mutations . We describe six patients from consanguineous Greenlandic Inuit family, homozygous for novel frame‐shift exon 22 (c.2473C>AA, p.Leu825AsnfsX32). Disease onset varied 10 to 29 years age, latest reported, and clinical...
Aggregation of alpha-synuclein (α-syn) is considered to be the major pathological hallmark and driving force Multiple System Atrophy (MSA) Parkinson's disease (PD). Immune dysfunctions have been associated with both MSA PD recently we reported that levels natural occurring autoantibodies (NAbs) high affinity towards α-synuclein are reduced in patients. Here, aimed evaluate plasma immunoglobulin (Ig) composition binding α-syn other amyloidogenic neuropathological proteins, correlate them...
The autosomal dominant spinocerebellar ataxias (SCAs) confine a group of rare and heterogeneous disorders, which present with progressive ataxia numerous other features e.g. peripheral neuropathy, macular degeneration cognitive impairment, subset these disorders is caused by CAG-repeat expansions in their respective genes. diagnosing the SCAs often difficult due to phenotypic overlap among several subtypes neurodegenerative Huntington's disease. We report family proband had rapidly...
The Faroe Islands are a geographic population isolated in the North Atlantic with high prevalence of Parkinson's disease (PD). Although environmental risk factors well described, familial aggregation PD on has yet to be explored. Complete ascertainment all patients was performed, including 217 cases and 251 control subjects. All were neurologically assessed diagnosed using UK Brain Bank criteria Hohn Yahr staging. Comprehensive genealogical detailed cartographic analyses performed. Relative...
Aim: To evaluate the diagnostic value of level α-synuclein, DJ-1, and Alzheimer's disease markers in cerebrospinal fluid (CSF) patients with parkinsonian syndromes. Materials & methods: We measured DJ-1 by quantitative immunoassays 122 CSF samples from Parkinson's (PD; n = 38), dementia Lewy bodies (n 20), multiple-system atrophy 18), progressive supranuclear palsy 28), corticobasal degeneration 7), unspecified atypical disorders 5) healthy controls 6). Results: The α-synuclein was...
Aim: The purpose of this study was to establish the influence centrifugation and protease activity on cerebrospinal fluid (CSF) concentrations DJ-1 hemoglobin. Materials & methods: hemoglobin were determined in 12 (DJ-1) six (hemoglobin) pairs CSF samples, with one sample being stored without other centrifuged at 2000 × g before storage. concentration also uncentrifuged containing inhibitors compared values samples inhibitors. Furthermore, specific protein from two groups, each comprising 23...
Abstract This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls. Autoinflammatory disorders typically involve immune mistakenly attacking body’s own cells start producing ANA. There is an increasing body evidence that immune-mediated inflammation a pathological feature linked synucleinopathies. To investigate whether...
Alzheimer's disease (AD) and Parkinson's (PD) are leading neurodegenerative disorders marked by protein aggregation, with AD featuring amyloid-beta (Aβ) tau proteins, PD alpha-synuclein (αSyn). Dementia Lewy bodies (DLB) often presents a mix of these pathologies. This study explores naturally occurring autoantibodies (nAbs), including Immunoglobulin (Ig)G, IgM, IgA, which target αSyn, Aβ to maintain homeostasis were previously found altered in patients, among others. We extended this...
ABSTRACT Background In a Danish family, multiple individuals in five generations present with early‐onset paroxysmal cranial dyskinesia, musculoskeletal abnormalities, and kidney dysfunction. Objective To demonstrate linkage to identify the underlying genetic cause of disease. Methods Genome‐wide single‐nucleotide polymorphisms analysis, Sequence‐Tagged‐Site marker analyses, exome sequencing, Sanger sequencing were performed. Results Linkage analyses identified candidate locus on chromosome...