A5064493397- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Point processes and geometric inequalities
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Nuclear Receptors and Signaling
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Balance, Gait, and Falls Prevention
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Cerebrovascular and genetic disorders
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Ubiquitin and proteasome pathways
- Genomic variations and chromosomal abnormalities
University of Copenhagen
2019-2024
Frederiksberg Hospital
2019-2024
Bispebjerg Hospital
2014-2024
Copenhagen University Hospital
2013-2024
John Wiley & Sons (United States)
2020
Hvidovre Hospital
2015
Aarhus University
2001
In Parkinson's disease (PD), dementia (PDD) and disease-mild cognitive impairment (PD-MCI) are common. PD-MCI is a risk factor for developing PDD. Knowledge of cognition in early-stages PD essential understanding predicting the process.We describe profile early-stage patients with no prior clinical suspicion impairment, depression or psychiatric disturbances, investigate possible features distinguishing deficits, defining risk-profile. Single Photon Emission Computerized Tomography (SPECT)...
The authors' aim was to compare the subthalamic nucleus (STN) with globus pallidus internus (GPi) as a stimulation target for deep brain (DBS) medically refractory dystonia.In prospective double-blind crossover study, electrodes were bilaterally implanted in STN and GPi of 12 patients focal, multifocal, or generalized dystonia. Each patient randomly selected undergo initial bilateral either 6 months, followed by other another months. Preoperative postoperative ratings assessed using...
ABSTRACT Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated nonmotor dysfunction. Objectives We used “neuromelanin sensitive” magnetic resonance imaging (MRI) to localize structural disintegration LC and its association with dysfunction PD. Methods A total 42 patients PD 24 age‐matched healthy volunteers underwent magnetization transfer weighted (MTw) MRI LC. The contrast‐to‐noise ratio MTw...
Dopaminergic signalling in the striatum contributes to reinforcement of actions and motivational enhancement motor vigour. Parkinson's disease leads progressive dopaminergic denervation striatum, impairing function cortico-basal ganglia networks. While levodopa therapy alleviates basal dysfunction disease, it often elicits involuntary movements, referred as levodopa-induced peak-of-dose dyskinesias. Here, we used a novel pharmacodynamic neuroimaging approach identify changes connectivity...
Objective In Parkinson disease (PD), long‐term treatment with the dopamine precursor levodopa gradually induces involuntary “dyskinesia” movements. The neural mechanisms underlying emergence of levodopa‐induced dyskinesias in vivo are still poorly understood. Here, we applied functional magnetic resonance imaging (fMRI) to map peak‐of‐dose patients PD. Methods Thirteen PD and 13 without received 200mg fast‐acting oral following prolonged withdrawal from their normal dopaminergic medication....
ABSTRACT Background Levodopa‐induced dyskinesias are a common side effect of dopaminergic therapy in PD, but their neural correlates remain poorly understood. Objectives This study examines whether associated with abnormal modulation resting‐state cortico‐striatal connectivity. Methods Twelve PD patients peak‐of‐dose and 12 without were withdrawn from medication. All received single dose fast‐acting soluble levodopa then underwent functional magnetic resonance imaging before any emerged....
To determine the extent of neocortical involvement in multiple system atrophy (MSA), we used design-based stereological methods to estimate total numbers neurons, oligodendrocytes, astrocytes, and microglia frontal, parietal, temporal, occipital cortex brains from 11 patients with MSA age- gender-matched control subjects. The data were supported by cell marker expression analyses tissue samples prefrontal cortex. We found significantly fewer neurons frontal parietal compared brains....
Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement motor function patients with advanced Parkinson's disease (PD). In this prospective study including 16 PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, only) and Danish (DanPSS, bother of symptoms) (2) bladder control (assessed urodynamics) before after implantation electrodes STN. PD (Unified Disease Rating Scale score) improved...
Aggregation of alpha-synuclein (α-syn) is considered to be the major pathological hallmark and driving force Multiple System Atrophy (MSA) Parkinson's disease (PD). Immune dysfunctions have been associated with both MSA PD recently we reported that levels natural occurring autoantibodies (NAbs) high affinity towards α-synuclein are reduced in patients. Here, aimed evaluate plasma immunoglobulin (Ig) composition binding α-syn other amyloidogenic neuropathological proteins, correlate them...
Abstract The hippocampal formation is a neuroanatomically well‐defined region of the brain involved in memory processes. In view functional importance and its involvement number pathologies, including Alzheimer's disease temporal lobe epilepsy, quantitative description vascular supply represents an important first step evaluating changes these phenomena. Unbiased estimates length connectivity regions have not been described previously. total number, length, distribution diameters capillaries...
We investigated lower-extremity isometric tremor Approximate Entropy (irregularity), torque steadiness and rate of force development (RFD) their associations to muscle activation strategy during knee extensions in patients with Parkinson’s disease (PD). Thirteen male idiopathic PD 15 neurologically healthy matched controls performed maximal contractions (extension/flexion) as well steady submaximal powerful extensions. The showed decreased irregularity. Torque was reduced the had increased...
Multiple system atrophy (MSA) is a rare disease with fatal outcome. To date, little known about the molecular processes underlying development. Its clinical overlap related neurodegenerative movement disorders underlines importance for expanding knowledge of pathological brain in MSA patients to improve distinction from similar diseases. In current study, we investigated DNA methylation changes samples 41 and 37 healthy controls. We focused on prefrontal cortex, moderately affected area MSA....
The role of electromyography (EMG) recorded from the external anal sphincter (EAS) in diagnosis atypical parkinsonian syndromes is a matter for continuous debate. Most studies addressing this issue are retrospective.In study, we prospectively investigated six patients with Parkinson's Disease (IPD), 14 multiple system atrophy (MSA) and eight progressive supranuclear palsy (PSP) using EMG EAS, motor-evoked potential (MEP) to EAS m. gastrocnemius nerve conduction velocity measured at sural...
Abstract Levodopa-induced dyskinesia gradually emerges during long-term dopamine therapy, causing major disability in patients with Parkinson disease. Using pharmacodynamic functional MRI, we have previously shown that the intake of levodopa triggers an excessive activation pre-supplementary motor area disease peak-of-dose dyskinesia. In this pre-registered, interventional study, tested whether abnormal responsiveness to may constitute a ‘stimulation target’ for treating A gender-balanced...