A5102027114- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
- Biomedical Text Mining and Ontologies
- Pharmaceutical studies and practices
- Chemical Safety and Risk Management
- Safe Handling of Antineoplastic Drugs
- Artificial Intelligence in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
- Schizophrenia research and treatment
- Diet and metabolism studies
- COVID-19 and healthcare impacts
- Medication Adherence and Compliance
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Pharmaceutical Economics and Policy
- Urinary and Genital Oncology Studies
- Opioid Use Disorder Treatment
- Academic integrity and plagiarism
- linguistics and terminology studies
- Acute Myocardial Infarction Research
Zealand University Hospital
2021-2023
Karolinska University Hospital
2023
Karolinska Institutet
2023
University of Copenhagen
2013-2023
Novo Nordisk Foundation
2014-2023
Nordsjællands Hospital
2020-2023
Copenhagen University Hospital
2019-2023
Rigshospitalet
2021
Foundation Center
2019
Glostrup Hospital
2019
Abstract A key prerequisite for precision medicine is the estimation of disease progression from current patient state. Disease correlations and temporal (trajectories) have mainly been analysed with focus on a small number diseases or using large-scale approaches without time consideration, exceeding few years. So far, no studies focused defining comprehensive set trajectories. Here we present discovery-driven analysis patterns data an electronic health registry covering whole population...
Drugs have tremendous potential to cure and relieve disease, but the risk of unintended effects is always present. Healthcare providers increasingly record data in electronic patient records (EPRs), which we aim identify possible adverse events (AEs) and, specifically, drug (ADEs).Based on undesirable section from summary product characteristics (SPC) 7446 drugs, built a Danish ADE dictionary. Starting this dictionary developed pipeline for identifying ADEs unstructured clinical narrative...
Data collected for medical, filing and administrative purposes in electronic patient records (EPRs) represent a rich source of individualised clinical data, which has great potential improved detection patients experiencing adverse drug reactions (ADRs), across all approved drugs indication areas. The aim this study was to take advantage techniques temporal data mining EPRs order detect ADRs patient- dose-specific manner. We used psychiatric hospital's EPR system investigate undesired...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity laboratory determinants of death ICU admission were explored in all Danish hospitalised patients.National health registries used to identify hospitalized patients with COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), results on prognostic factors for using multivariate Cox proportional hazard regression...
Abstract Purpose While the beneficial effects of medications are numerous, drug–drug interactions may lead to adverse drug reactions that preventable causes morbidity and mortality. Our goal was quantify prevalence potential in prescriptions at Danish hospitals, estimate risk outcomes associated with discouraged combinations, highlight patient types (defined by primary diagnosis admission) appear be more affected. Methods This cross‐sectional (descriptive part) cohort study (adverse used...
Viral shedding and neutralizing antibody (NAb) dynamics among patients hospitalized with severe coronavirus disease 2019 (COVID-19) immune correlates of protection have been key questions throughout the pandemic. We investigated duration reverse transcriptase-polymerase chain reaction (RT-PCR) positivity, infectious viral NAb titers as well association between severity in COVID-19 Denmark 2020-2021.
Systems for the preparation and administration of drugs are designed to ensure that drug is not contaminated. They do necessarily consider work environment medical staff new techniques therefore desirable. The aim this compare a closed system with traditional technique regard airborne emission surface spillage drugs. Platinum, determined using adsorptive voltammetry, was used as tracer emission. Air samples were collected during administration, platinum on filters by voltammetry. For...
Abstract Pharmaceutical product information ( PI ) supplied by the regulatory authorities serves as a source of on safe and effective use drugs. The objectives this study were to qualitatively quantitatively compare s for selected drugs marketed in both Denmark USA with respect consistency discrepancy listed adverse drug reaction ADR information. We compared individual from type frequency. Consistency was defined match frequency or could not be ruled out. Discrepancies only one country...
New pharmacovigilance methods are needed as a consequence of the morbidity caused by drugs. We exploit fine-grained drug related adverse event information extracted text mining from electronic medical records (EMRs) to stratify patients based on their events and determine co-occurrences.We analyzed similarity profiles 2347 EMRs mental health center in Denmark. The were clustered similarities presented network. set each main patient cluster was evaluated. Co-occurrences (p-value < 0.01)...
COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, underlying pathogenesis unclear. We aimed to provide novel immunological genetic descriptions MIS-A patients. Cytokine responses (IL-6, IL-1β, TNFα, CXCL10, type I, II III interferons) following SARS-CoV-2 infection peripheral blood mononuclear cells in vitro were...
Background: Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which also affect turnover. Methods: In planned secondary analyses of a three-month, double-blind, randomized, placebo-controlled trial (n=45), we explored effects the GLP-1 agonist exenatide 2 mg once-weekly (n=23), or placebo (n=22) on turnover markers (BTMs)...
Understanding sex differences in adverse drug reactions to drugs for psychosis could potentially guide clinicians optimal choices.By applying a text-mining approach, this study aimed investigate the relationship between and biological frequencies co-occurrences of potential events (ADEs).Electronic patient records psychiatric population (1427 men 727 women) were text mined ADEs. The relative risk experiencing specific ADEs co-occurrence calculated each sex.Findings included 55 with...
Periodic revisions of the international classification diseases (ICD) ensure that reflects new practices and knowledge; however, this complicates retrospective research as diagnoses are coded in different versions. For longitudinal disease trajectory studies, a crosswalk is an essential tool comprehensive mapping between ICD-8 ICD-10 has until now been lacking. In study, we map all morbidity codes to expanded Danish ICD version. We mapped ICD-10, using many-to-one system inspired by general...
Abstract Background Patients diagnosed with ischemic heart disease (IHD) are becoming increasingly multi-morbid, and studies designed to analyze the full spectrum few. Methods Disease trajectories, defined as time-ordered series of diagnoses, were used study temporality multi-morbidity. The main data source was Danish National Patient Register (NPR) comprising 7,179,538 individuals in period 1994–2018. a diagnosis code for IHD included. Relative risks quantify strength association between...
Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation severity. This hampers the study of etiological differences reduces statistical power analyses associations to genetics, treatment outcomes, complications. We address these issues through deep, fine-grained stratification diabetes cohort. Text mining electronic health records 14,017 patients, we matched two controlled vocabularies (ICD-10 custom vocabulary developed at clinical center Steno...
Anti-cancer drugs are reactive compounds with known adverse health effects. To prevent occupational exposure to these drugs, there are, in most countries, regulations for handling anti-cancer drugs. Many preparation systems available, e.g. isolators, biological safety cabinets (BSCs), filter spikes (venting micro-pore filter) and closed (e.g. PhaSeal™). Although used, reports of exposure. This causes concern over how efficient spill leakage that may cause undesired when cytotoxic Today, this...
Abstract Background : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19), is a worldwide emergency. Demographic, clinical laboratory factors with mortality in Danish patients hospitalised COVID-19 limited. Methods: National health registries were used to identify all hospitalized diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), results on admission explored prognostic for death using multivariate Cox proportional...
Medication errors have been identified as the most common preventable cause of adverse events. The lack granularity in medication error terminology has led pharmacovigilance experts to rely on information individual case safety reports' (ICSRs) codes and narratives for signal detection, which is both time consuming labour intensive. Thus, there a need complementary methods detection from ICSRs. aim this study evaluate utility two natural language processing text mining tools traditional...
Polypharmacy has generally been assessed by raw counts of different drugs administered concomitantly to the same patients; not with respect likelihood dosage-adjustments. To address this aspect polypharmacy, objective present study was identify co-medications associated more frequent dosage adjustments. The data foundation electronic health records from 3.2 million inpatient admissions at Danish hospitals (2008-2016). dosage-adjustments when two were computed using Bayesian logistic...
Abstract Background Most structured clinical data, such as diagnosis codes, are not sufficient to obtain precise phenotypes and assess disease burden. Text mining of notes could provide a basis for detailed profiles phenotypic traits. The objective the current study was determine whether drug dose, regardless polypharmacy, is associated with length notes, frequency adverse events per word in notes. Methods In this observational study, we utilized restricted-access data from an electronic...
Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which also affect turnover. The current study comprises planned secondary analyses of the 'TAO study': Treatment antipsychotic-associated obesity with a GLP-1 agonist. TAO was investigator-initiated, double-blind, randomized, placebo-controlled trial, investigating effects...
Abstract Importance While the beneficial effects of medications are numerous, drug-drug interactions may lead to adverse drug reactions that preventable causes morbidity and mortality. Objective To quantify prevalence potential in prescriptions at Danish hospitals, estimate risk outcomes associated with discouraged combinations, highlight patient types (defined by primary diagnosis admission) appear be more affected. Design Cross-sectional (descriptive part) cohort study (adverse part)....