A5031070879- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Genetics and Neurodevelopmental Disorders
- Celiac Disease Research and Management
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
Steno Diabetes Centers
2015-2025
University of Copenhagen
2016-2025
Herlev Hospital
2015-2025
Capital Region of Denmark
2018-2023
Copenhagen University Hospital
2013-2022
University of Tennessee Health Science Center
2022
University of Cambridge
2022
Gentofte Hospital
2015-2021
Glostrup Hospital
2010-2014
Lund University
2005-2013
Abstract. In the present study we searched for restriction fragment length polymorphisms (RFLP) in human interleukin‐1β (IL‐lβ) gene and correlations to monocyte (Mo) function non‐related healthy donors insulin‐dependent diabetic patients. We demonstrated a diallelic polymorphism with enzyme TaqI consisting of fragments 9.4 kb 13.4 kb. No differences allele or genotype frequencies this RFLP were observed between randomly selected controls patients diabetes mel‐litus (IDDM). However, when...
The tumor necrosis factor (TNF) alpha gene lies within the class III region of major histocompatibility complex (MHC), telomeric to II and centromeric I region. We have recently described first polymorphism human TNF-alpha locus. This is biallelic promoter Frequency analysis polymorphism, using polymerase chain reaction single-stranded conformational in HLA-typed individuals, reveals a very strong association between uncommon TNF allele HLA A1, B8, DR3 alleles. other MHC alleles raises...
We have investigated the correlation between different tumor necrosis factor (TNF) and class II major histocompatibility complex alleles in lipopolysaccharide- or phytohemagglutinin-induced secretion of TNF-alpha TNF-beta by human monocytes peripheral blood mononuclear cells 87 unrelated Danish male individuals. Significant differences secretory capacity TNF NcoI restriction fragment length polymorphisms, TNFa TNFc microsatellite DR were identified. No with was found for any markers studied....
This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera from new onset T1D age-matched healthy controls related the levels function glycaemic control. Global miRNA sequencing analyses were performed on pools two cohorts ( n = 275 129, resp.) one control group 151). identified twelve upregulated human patients (miR-152, miR-30a-5p, miR-181a,...
Type 1 diabetes is a common, multifactorial disease with strong familial clustering (genetic risk ratio [λS] ∼ 15). Approximately 40% of the aggregation type can be attributed to allelic variation HLA loci in major histocompatibility complex on chromosome 6p21 (locus-specific λS 3). Three other susceptibility have been clearly demonstrated based their direct effect risk, INS (chromosome 11p15, odds [OR] 1.9), CTLA4 2q33, OR 1.2), and PTPN22 1p13, 1.7). However, large proportion remains...