A5000732902- Herpesvirus Infections and Treatments
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Travel-related health issues
- Bartonella species infections research
- Malaria Research and Control
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Parasites and Host Interactions
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
- Diphtheria, Corynebacterium, and Tetanus
- Eosinophilic Esophagitis
- Reproductive tract infections research
- Abdominal Trauma and Injuries
- Food Allergy and Anaphylaxis Research
- Streptococcal Infections and Treatments
University Hospital Hradec Králové
2005-2021
Charles University
2010-2018
Ocní klinika
2007-2018
Ministry of Education Youth and Sports
2016
University of Defence
2016
Schistosomiasis remains one of the most prevalent parasitic diseases worldwide and infection is frequently found in travelers migrants. The European Network for Tropical Medicine Travel Health conducted a sentinel surveillance study on imported schistosomiasis between 1997 2010. This report summarizes epidemiological clinical data from 1,465 cases schistosomiasis. Direct pathogen detection serology were main diagnostic tools applied. Of these, 486 (33%) identified among travelers, 231 (16%)...
Approximately 10 years after vaccination with the recombinant zoster vaccine (RZV), an interim analysis of this follow-up study ZOE-50/70 trials demonstrated that efficacy against herpes remained high. Moreover, safety profile clinically acceptable, suggesting clinical benefit RZV in ≥50-year-olds is sustained up to years.
Abstract Background This ongoing follow-up study evaluated the persistence of efficacy and immune responses for 6 additional years in adults vaccinated with glycoprotein E (gE)-based adjuvanted recombinant zoster vaccine (RZV) at age ≥50 2 pivotal trials (ZOE-50 ZOE-70). The present interim analysis was performed after ≥2 (between 5.1 7.1 [mean] post-vaccination) includes partial data year (Y) 8 post-vaccination. Methods Annual assessments were against herpes (HZ) from Y6 post-vaccination...
Pertussis immunization during pregnancy is recommended in many countries. Data from large randomized controlled trials are needed to assess the immunogenicity, reactogenicity and safety of this approach. This phase IV, observer-blind, randomized, placebo-controlled, multicenter trial assessed transplacental transfer maternal pertussis antibodies, a reduced-antigen-content diphtheria-tetanus-three-component acellular vaccine (Tdap) pregnancy. Women received Tdap or placebo at 27–36 weeks’...
Individuals with functional or anatomic asplenia are at high risk for meningococcal disease. We evaluated the immunogenicity and safety of 1 2 doses quadrivalent serogroups A, C, W, Y tetanus toxoid-conjugate vaccine (MenACWY-TT) in this high-risk population. This phase III, open-label, controlled, non-randomized study (NCT01641042) enrolled 1–17-year-olds impaired splenic activity (high-risk group) age-matched healthy controls (control group). measured immune responses to MenACWY-TT by...
Transplacentally transferred antibodies induced by maternal pertussis vaccination interfere with infant immune responses to primary vaccination. We evaluated whether this interference remains in toddlers after booster In a prior phase IV, observer-blind, placebo-controlled, randomized study (NCT02377349), pregnant women Australia, Canada and Europe received intramuscular tetanus-reduced-antigen-content diphtheria-three-component acellular vaccine (Tdap group) or placebo (control at...
Objectives: Monitoring of the varicella-zoster virus is becoming an important tool for analysis circulation individual strains VZV which differ not only at genomic level, but show a variability in their clinical and epidemiological characteristics. Such data are available on large scale from Czech population could help understanding evolutionary characteristics virus, as well its potential reinfection increased pathogenesis groups higher risk complications. The main aim this study was...
We report a case of multi-recurrent herpes zoster in 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over years 2009 - 2011.Specific PCR methods targeting single nucleotide polymorphisms (SNPs) open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons ORF 22 and/or 21/ORF 50. Additional genotyping 1, 6, 9 28 was subsequently...
Abstract Tick-borne encephalitis (TBE) is a vector-borne infection associated with variety of potentially serious complications and sequelae. Vaccination against TBE strongly recommended for people living in endemic areas. There are two vaccination schemes – standard rapid which differ the onset protection. With schedule, protection starts as early 4 weeks after first dose therefore especially non-immune individuals travelling to Both work reliably immunocompetent individuals, but only...
Background: VZV is unique among the herpesviruses in its transmission by inhalation of aerosolized virus particles. Infection via respiratory route increases opportunity for rapid spread through susceptible populations and exposure those already latently infected. Methods: A total 438 clinical samples were obtained from patients exhibiting symptoms varicella zoster infection manifested as chickenpox or herpes treated Faculty Hospital Charles University, Medical School Hradec Kralove, Czech...
Cíl práce: Plané neštovice jsou vysoce infekčním nicméně preventabilním onemocněním, proti kterému lze očkovat. Přesto v České republice patří mezi nejčastější infekční onemocnění vůbec, podléhající povinnému hlášení. Během let 2009 – 2016 jsme rámci molekulárně genetické studie varicella zoster viru (VZV) analyzovali soubor ambulantních a hospitalizovaných pacientů s diagnózou nebo herpes z Fakultní nemocnice Hradec Králové, Česká republika (FN HK).Materiál metody: Celkem 463 osob...