A5011158766- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Education, Psychology, and Social Research
- Liver Diseases and Immunity
- Cervical Cancer and HPV Research
- COVID-19 diagnosis using AI
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Child and Adolescent Health
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Pediatric health and respiratory diseases
- Syphilis Diagnosis and Treatment
University Hospital Hradec Králové
2011-2025
Charles University
2012-2025
University of Hradec Králové
2011-2021
Ministry of Health
2020
University of Defence
2007-2019
University of Oxford
2016
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2016
Johannes Gutenberg University Mainz
2016
Military University
2008-2013
Szpital Uniwersytecki w Krakowie
2012
<h3>Context</h3>In the absence of an effective vaccine, serogroup B Neisseria meningitidis (MenB) remains a major cause invasive disease in early childhood developed countries.<h3>Objective</h3>To determine immunogenicity and reactogenicity multicomponent MenB vaccine (4CMenB) routine infant vaccines when given either concomitantly or separately.<h3>Design, Setting, Participants</h3>Phase 2b, multicenter, open-label, parallel-group, randomized controlled study 1885 infants enrolled at age 2...
The novel meningococcal serogroup B vaccine (4CMenB, Bexsero®), recently approved in Europe and Australia, may soon be included routine infant immunization schedules, subject to guidance from national or regional recommending bodies. In the development of 4CMenB consistent with other newly introduced vaccines, clinical studies have shown concomitant administration vaccines induces an incremental increase some reactions, including fever. As this hinder acceptability, we examined impact...
The beginning of the coronavirus disease (COVID-19) epidemic dates back to December 31, 2019, when first cases were reported in People's Republic China. In Czech Republic, three infection with novel confirmed on March 1, 2020. joint effort state authorities and researchers gave rise a unique team, which combines methodical knowledge real-world processes know-how needed for effective processing, analysis, online visualization data.Due an urgent need tool that presents important reports based...
To provide broader protection against pneumococcal disease, new vaccines containing conserved Streptococcus pneumoniae proteins are being developed. This study assessed the safety, reactogenicity and immunogenicity of four formulations pneumolysin toxoid (dPly) histidine triad protein (PhtD) in toddlers.In this phase II, multicenter, observer-blind (www.clinicaltrials.gov: NCT00985751) conducted Czech Republic, toddlers (12-23 months) were randomized (1:1:1:1:1) to receive one...
We estimate and describe the incidence rates, mortality, cost of CAP (community-acquired pneumonia), in both inpatient outpatient settings, Czech Republic (CZ), Slovakia (SK), Poland (PL), Hungary (HU). A retrospective analysis was conducted on administrative data from health ministry insurance reimbursement claims with a primary diagnosis pneumonia 2009 to determine hospitalization costs, mortality adults ≥50 years age. Patient chart reviews were number cases. Among all years, hospitalized...
We undertook an epidemiological survey of the annual incidence pertussis reported from 2000 to 2013 in ten Central and Eastern European countries ascertain whether increased reports some share common underlying drivers or there are specific features each country. The participating was obtained relevant government institutions and/or national surveillance systems. reviewed changes rates country explore differences similarities between relation surveillance; case definitions for detection...
Antigen testing for SARS-CoV-2 (AGT) is generally considered inferior to RT-PCR in terms of sensitivity. However, little known about the infectiousness positive patients who pass undetected by AGT. In a screening setting mildly symptomatic or asymptomatic with high COVID-19 prevalence (30–40%), 1141 were tested using one five AGTs and RT-PCR. Where results differed, virus viability samples was on cell culture (CV-1 cells). The test battery included JOYSBIO, Assure Tech, SD Biosensor,...
Vaccine hesitancy (VH) is a state of indecision regarding vaccination, marked by doubts despite vaccine availability. 1 Its relationship with uptake has been widely debated, though the cause-effect remains unclear. Nevertheless, VH likely threatens control vaccine-preventable diseases, such as measles and hepatitis B, imposing unnecessary burdens on health systems.Inappropriate access to information, inadequate offers, administration have identified primary contributors reluctance...
Human papillomavirus (HPV) infections are highly prevalent sexually transmitted infections, notably associated with various cancers. This study analyses the health and economic impacts of HPV-associated diseases in Czech Republic evaluates cost-effectiveness a catch-up vaccination program. Utilizing Markov multistate model, assesses lifetime costs related to HPV infections. Cohorts ages 15–21 were simulated assess impact outside 11-year-old age group. The total quality-adjusted life years...