A5019780581- Ear Surgery and Otitis Media
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Sinusitis and nasal conditions
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Cancer Studies
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Congenital Ear and Nasal Anomalies
- Head and Neck Anomalies
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Ophthalmology and Eye Disorders
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Olfactory and Sensory Function Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Lung Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Glaucoma and retinal disorders
Charles University
2015-2024
University Hospital Hradec Králové
2015-2024
University of Hradec Králové
2022-2024
University of Pardubice
2008-2010
Pardubice Region
2009
Hamad General Hospital
2002
<h3>Background</h3> Standard treatment of oropharyngeal squamous cell carcinoma (OPSCC) is associated with high morbidity, whereas immunotherapeutic approaches using PD-1:PD-L1 checkpoint blockade only show moderate response rates in OPSCC patients. Therefore, a better stratification patients and the development novel therapeutic protocols are crucially needed. The importance tumor-infiltrating B cells (TIL-Bs) shaping antitumor immunity remains unclear; therefore, we analyzed frequency,...
Introduction: The Tinnitus Handicap Inventory (THI) is a key tool for assessing the impact of tinnitus on patient‘s life, emotional state and sleep quality, allowing treatment planning monitoring. It also used by researchers to collect data, contributing better understanding this complex dia gnosis. Methodology: linguist then compiled these versions into fi nal version, which was edited best comprehensibility while preserving original meaning questions. This Czech version translated back...
Abstract We stratified post-COVID patients into four newly established clinical groups based on the presence or absence of at least one subjective respiratory symptom and objective sign pulmonary involvement. Nearly half outpatients third hospitalized had signs involvement without accompanying symptoms three months after diagnosis.
Central skull-base osteomyelitis (CSBO) represents a life-threatening complication of external ear canal infection. Computed tomography (CT) and magnetic resonance imaging (MRI) play key roles in assessment CSBO progression. Twelve patients with were included retrospective clinical study. In total, 62 scans (30 CTs 32 MRIs) performed to evaluate the extent inflammatory changes. The read independently by two radiologists specialised head neck. regions under skull base specified using online...
Abstract Objective: To identify deep neck infection factors related to life-threatening complications. Methods: This retrospective multi-institutional study comprised 586 patients treated for infections between 2002 and 2012. The statistical significance of variables associated with complications was assessed. Results: During treatment, occurred in 60 out cases. On univariate analysis, were linked to: dyspnoea, movement disturbance dysphonia (all p < 0.001); parapharyngeal, anterior...
Abstract Objectives To assess the reliability of temporal fascia and bone graft for closure septal perforation. Study design Prospective longitudinal non-randomized. Methods The repair perforation was performed using endonasal dissection; suture borders on at least one side, interposition a with bone, either perpendicular plate ethmoid (six) if available or mastoid cortex (three) not. Results All patients had without re-perforation. Eight out nine complete (88.8 per cent). These perforations...
The goals of this retrospective cohort study were to compare the results clinical and pathological TNM staging in patients with laryngeal squamous cell carcinoma determine impact discordance on prognosis treatment results.A total 124 cancer, primarily indicated for surgical treatment, enrolled.The concordance or between was compared frequency cancer relapse diseasespecific survival.Other potential prognostic factors, like age, stage location primary tumor, status neck lymph nodes,...
MicroRNAs (miRNAs) are non-coding regulatory molecules 18-25 nucleotides in length that act as post-transcriptional regulators of gene expression. MiRNAs affect various biological processes including carcinogenesis. Deregulation miRNAa expression has been described a variety tumors papillary thyroid carcinoma (PTC). The aim the present study was to investigate role selected miRNAs PTC and find associations between miRNA BRAF (V600E) mutation.The group comprised total 62 patients with...
The following position statement from the Union of European Phoniatricians, updated on 25th May 2020 (superseding previous issued 21st April 2020), contains a series recommendations for phoniatricians and ENT surgeons who provide and/or run voice, swallowing, speech language, or paediatric audiology services.
Balloon Eustachian tuboplasty (BET) appears to be a promising therapeutic option for tube dysfunction. However, data are lacking on its effect in adults with chronic otitis media effusion (COME) and whether it should combined tympanocentesis. The aim of our study was determine if there is beneficial BET tympanocentesis compared only provide the COME.Randomized clinical trial.Tertiary referral hospital.Adults COME lasting more than 6 months after tympanostomy exclusion. Among 40 eligible...
Objectives: Balloon eustachian tuboplasty (BET) is a promising therapeutic option for tube (ET) dysfunction. However, data are lacking on the effect of BET in adults with symptoms chronic ET dysfunction but without contributing pathology. This study investigated adult patients only Methods: prospective clinical trial included aerated physiological middle ears and more than 6 months. Compliance follow-up was 93.3%. We evaluated effects tympanometry, assessment Valsalva or Toynbee maneuver...
We aimed to assess the ability of a head-shaking test (HST) reflect vestibular compensation in patients after unilateral peripheral loss and provide missing evidence new insights into features head-shaking-induced nystagmus (HSN) over 2-year follow-up.HSN may occur prolonged sinusoidal oscillation head. HSN is frequently observed subjects with function asymmetry; it usually beats toward functionally intact or "stronger" ear can be followed by reversal its direction.A prospective...