A5062410949- Voice and Speech Disorders
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Phonetics and Phonology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenetic and Muscular Disorders Research
- Streptococcal Infections and Treatments
- Head and Neck Surgical Oncology
- Cleft Lip and Palate Research
- Oropharyngeal Anatomy and Pathologies
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Botany and Plant Ecology Studies
- Oral and Maxillofacial Pathology
Leiden University Medical Center
2014-2024
Leiden University
2013-2020
Netherlands Comprehensive Cancer Organisation
2006
<h3>Objective</h3> To compare voice quality after radiotherapy or endoscopic laser surgery in patients with similar T1a midcord glottic carcinomas according to a validated multidimensional protocol. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> University cancer referral center. <h3>Patients</h3> Two cohorts of consecutive willing participate treatment for primary carcinoma (18 23 eligible) (16 18 eligible). <h3>Main Outcome Measures</h3> Posttreatment was evaluated protocol...
Acronyms and abbreviations are frequently used in otorhinolaryngology other medical specialties. CO2 laser-assisted transoral surgery of the pharynx, larynx upper airway is a family commonly performed surgical procedures termed laser microsurgery (TLM). The abbreviation TLM can be confusing because alternative modes delivery. Classification definition different types procedures, transorally or transnasally, proposed by Working Committee for Nomenclature European Laryngological Society,...
Abstract Background Since the introduction of endoscopic laser surgery at our institution in 1996, 189 patients have been treated for T1 glottic carcinoma. Methods Treatment allocation (radiotherapy vs surgery) and outcome were evaluated. Results Fifty‐one percent T1a lesions considered suitable surgery. Sixteen with needed additional treatment because positive resection margins. Overall local control larynx preservation 89% 96%. Both poorer larger radiotherapy (local 75% versus 89%, p =...
To assess the impact of surgical margins status on local control in patients with primary early glottic (Tis-T2) squamous cell carcinoma after treatment transoral CO2 laser microsurgery (TLM) and to significance additional wound bed biopsies. Patients Tis-T2 tumours treated TLM type I–III resections according European Laryngological Society classification between 2009 2013 were included retrospective analysis. Recurrence rate was determined free versus non-free specimen Five-year survival...
We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters were by uni- multivariate analysis 316 consecutive irradiated patients with T1 carcinoma Comprehensive Cancer Center West region western Netherlands. Median follow-up was 70 months (range 1-190 months). Five ten-year local control 86 84%. Disease specific survival 97% at 5 10 years. In analysis, pre-existent laryngeal hypertrophic laryngitis only...
For early glottic carcinoma, the 2 main treatment modalities are radiotherapy (RT) and transoral CO2 laser microsurgery (TLM). The aim of this study was to investigate preferences considerations in patients with carcinoma (T1-T2) who were given a choice between TLM RT.Patients cancer (suspected or confirmed extended T1 limited T2) counseled by an ENT-surgeon. A subset 32 also radiotherapist. Treatment recorded analyzed.Of 175 patients, 168 (96%) chose TLM, 7 (4%) RT. most common reason for...
As the benefits, limitations, and contraindications of transoral laser microsurgery (TLM) in glottic carcinoma treatments become better defined, pretreatment imaging has more important to assess case-specific suitability TLM predict functional outcomes both for treatment consideration patient counseling. Magnetic resonance (MRI) is preferred modality image such laryngeal tumors, even though larynx using MRI can be difficult. The first challenge that there are no commercial radiofrequency...
Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) voice outcome. This is important when counseling patients or choosing a primary treatment modality. The present study assessed (2 years) QoL outcome with extended T1 limited T2 glottic carcinoma treated transoral CO2 laser microsurgery (TLM) (unilateral type III bilateral II resections). Three questionnaires were administered: the Voice...
To evaluate the outcome of bilateral trial vocal fold injection (VFI) with hyaluronic acid in patients atrophy ± sulcus and to assess predictive value VFI on durable medialization procedure.Voice data collected according a standardized protocol before one month after 68 (30) (38) were analyzed. Voice Handicap Index (VHI)-30 was compared at 3 12 months.The overall VHI-30 improvement 16.8 points (from 49.9 33.1), which statistically significant clinically relevant. 57.8% experienced enough...
Abstract Background There is a considerable diagnostic delay in the diagnosis ‘benign acquired subglottic stenosis adults’ (SGS, diagnosed by reference standard, i.e. laryngo- or bronchoscopy). Patients are frequently misdiagnosed since symptoms of this rare disease may mimic ‘asthma.’ The ‘Expiratory Disproportion Index’ (EDI) obtained spirometry, be simple instrument to detect an SGS-patient. aim study was evaluate accuracy EDI differentiating SGS patients from asthma patients. Methods We...
ABSTRACT Background Little is known about the swallowing disturbances of patients with Huntington's disease; therefore, we developed Disease Dysphagia Scale. Methods The scale was in four stages: (1) item generation, (2) comprehension testing, (3) evaluation reliability, (4) reduction and validity testing. questionnaire presented twice to 50 disease their caregivers. Kruskal‐Wallis test used evaluate whether severity difficulties increased advancing disease. Pearson's correlation coefficient...
The purpose of the study was to assess role laser-assisted posterior cordectomy in management patients with bilateral vocal cord paralysis. We aimed an analysis 132 consecutive treated by CO2 laser cordectomy, aged 38–91, 31% tracheotomized on admission. Cordectomy performed under microlaryngoscopy using (Lumenis AcuPulse 40 laser, wavelength 10.6 μm, Lumenis Ltd., Yokneam, Israel). looked at number glottic procedures necessary achieve decannulation and respiratory comfort non-tracheotomized...
To evaluate voice outcome after bilateral vocal fold injection with autologous fat in patients non-paralytic glottic insufficiency due to atrophy or without sulcus. This is a retrospective cohort study from September 2012 December 2017 including 23 undergoing (24 procedures) for (15 sulcus (Ford type II III) (9 procedures). Voice data were collected and analyzed the preoperative 3- 12-month postoperative time points according standardized protocol, Handicap Index (VHI)-30 perceptive,...
Objectives/Hypothesis The current gold standard of therapy for adductor spasmodic dysphonia (AdSD) is injection botulinum toxin A (BTX) in the musculature. surgical procedure could potentially offer more stable and long‐lasting voice quality. In this study, we report long‐term results endoscopic laser thyroarytenoid (TA) myoneurectomy versus BTX treatment same patients with AdSD. Study Design Retrospective case series. Methods Between July 2013 September 2016, a total 22 AdSD were included....