A5014376044- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Hearing Loss and Rehabilitation
- Nanoparticle-Based Drug Delivery
- Ear Surgery and Otitis Media
- Radioactive Decay and Measurement Techniques
- Vestibular and auditory disorders
- Radiation Dose and Imaging
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Health and Medical Studies
- Radiomics and Machine Learning in Medical Imaging
- Voice and Speech Disorders
- Chemical Reactions and Isotopes
- Ear and Head Tumors
- Radiation Detection and Scintillator Technologies
- Education, Psychology, and Social Research
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
Czech Academy of Sciences
2008-2025
Czech Academy of Sciences, Institute of Microbiology
2007-2025
University Hospital in Motol
2008-2024
Charles University
2013-2024
North Metropolitan Health Service
2021
East Metropolitan Health Service
2021
The University of Western Australia
2003-2017
Sir Charles Gairdner Hospital
2007-2014
Harry Perkins Institute of Medical Research
2010
Water Research Institute
2007
Human papillomavirus (HPV) infection is one of the most important etiologic causes oropharyngeal head and neck squamous cell carcinoma (HNSCC). Patients with HPV-positive HNSCC were reported to have a better clinical outcome than patients HPV-negative cancers. However, little known about possible different outcomes. In this study, we analyzed detailed immune profile tumor samples from respect their HPV status. We characteristics infiltrates, including frequency distribution...
The aim of chemotherapy for mesothelioma is to palliate symptoms and improve survival. Measuring response using CT challenging because the circumferential tumor growth pattern. This study aims evaluate role serial <sup>18</sup>F-FDG PET in assessment patients with mesothelioma. <b>Methods:</b> Patients were prospectively recruited underwent both conventional radiological before after 1 cycle chemotherapy. Quantitative volume-based analysis was performed obtain total glycolytic volume (TGV)...
Coincidence imaging of low-abundance yttrium-90 (90Y) internal pair production by positron emission tomography with integrated computed (PET/CT) achieves high-resolution post-radioembolization microsphere biodistribution. Part 2 analyzes tumor and non-target tissue dose-response 90Y PET quantification evaluates the accuracy 99mTc macroaggregated albumin (MAA) single-photon CT (SPECT/CT) predictive dosimetry.Retrospective dose resin microspheres was performed on same 23-patient data set in...
<h3>Background</h3> Standard treatment of oropharyngeal squamous cell carcinoma (OPSCC) is associated with high morbidity, whereas immunotherapeutic approaches using PD-1:PD-L1 checkpoint blockade only show moderate response rates in OPSCC patients. Therefore, a better stratification patients and the development novel therapeutic protocols are crucially needed. The importance tumor-infiltrating B cells (TIL-Bs) shaping antitumor immunity remains unclear; therefore, we analyzed frequency,...
Several lines of study suggest that peripheral metabolism amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% Aß complexed as an apolipoprotein, raising the possibility a lipoprotein-mediated axis AD risk. this study, we report genetic modification C57BL/6J mice engineered to synthesise human only in liver (hepatocyte-specific (HSHA) strain) has marked neurodegeneration concomitant capillary dysfunction, parenchymal extravasation lipoprotein-Aß,...
Existing prognostic systems for malignant pleural mesothelioma do not incorporate imaging information. We aimed to identify the contribution of quantitative fluorodeoxyglucose positron emission tomography (FDG-PET) analysis other variables in this disease.Patients with underwent helical thoracoabdominal computed and FDG-PET scans at baseline. Patients were treated as clinically indicated followed survival. derived included total glycolytic volume, a composite tumor volume...
Narrow band imaging is considered a significant improvement in the possibility of detecting early mucosal lesion upper aerodigestive tract. Early detection neoplastic lesions utmost importance for patients survival. There evidence that, especially previously treated by means curative radiotherapy or chemoradiotherapy, rate recurrent disease quite low. The aim this study was to prove whether videoendoscopy coupled with NBI might help detect secondary tumors 66 RT CRT intent were enrolled...
Background . Human papillomaviruses (HPVs) have been proved as one of the etiological factors oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors viral etiology a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in immune system. Only limited number studies correlated both immunological parameters HPV status patient The aim this study was determine whether infection influence prognosis individually or concurrence. Material Methods Sixty patients...
Regulatory T cells (Treg) are important regulators of anti-cancer immune responses, and an increase in Treg frequency was observed the blood cancer patients. Blood samples from 112 patients with head neck squamous cell carcinoma antigen (HNSCC) were obtained at time tumour diagnosis, lymphocyte subpopulations (CD3(+); CD3(-)CD16(+)CD56(+); CD4(+); CD8(+); CD19(+); CD4(+)CD45RA(+)) emphasis on counts (CD3(+)CD4(+)CD25(+)), complete count markers (squamous [SCC]; CEA; alpha-1-antitrypsin...
In order to increase the availability and affordability of radioimmunotherapy refractory or relapsed non-Hodgkins lymphoma, we developed evaluated radioiodinated rituximab in an ongoing physician-sponsored Phase II Clinical Trial. The chimeric 1gG1 anti CD 20 monoclonal antibody was radiolabeled with iodine-131 using a modified Chloramine T method high radiochemical purity (98% ± 0.82) preservation immunoreactivity. All patients received therapeutic loading doses unlabeled (375 mg/m2)...
Purpose: The microenvironment established by stromal cells may or not influence phenotypic aspects of epithelial and be relevant for tumor stem cell biology. We address this issue keratinocytes using tumor-derived in a co-culture system.Materials methods: isolated from human squamous carcinoma tissue studied their effect on characteristics normal interfollicular vitro.Results: Stromal fibroblasts significantly immuno- lectin cytochemical properties co-cultured keratinocytes. Expression...
SUVmax is currently the most common semi-quantitative method of response assessment on FDG PET. By defining tumour volume interest (VOI), a measure total glycolytic (TGV) may be obtained. We aimed to comprehensively examine, in phantom setting, accuracy TGV reflecting actual lesion activity and compare with for assessment. The algorithms VOI generation from which was derived included fixed threshold techniques at 50% maximum (MAX50), 70% (MAX70), an adaptive (maximum + background)/2 (BM50)...
Objectives/Hypothesis Thyroid cancer, with 6% to 10% of cancer diagnoses, is one the most common malignancies during pregnancy. Its treatment poses a risk for pregnancy, as thyroid gland plays crucial role in evolution The aim this study evaluate primary well‐differentiated carcinoma pregnancy and fetal maternal outcomes. Study Design This an international cohort study. Methods Primary patients were identified from database International Network on Cancer, Infertility, Pregnancy registration...