A5076861458- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Reproductive tract infections research
- Bee Products Chemical Analysis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Essential Oils and Antimicrobial Activity
- Antimicrobial agents and applications
- Chemistry and Chemical Engineering
- Syphilis Diagnosis and Treatment
- Poxvirus research and outbreaks
- Viral Infections and Vectors
- Microbial infections and disease research
- Mosquito-borne diseases and control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Environmental Chemistry and Analysis
- Plant Toxicity and Pharmacological Properties
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- Female Genital Mutilation/Cutting Issues
- Bartonella species infections research
- Insect and Pesticide Research
- Advanced Drug Delivery Systems
- Vector-borne infectious diseases
University of Defence
2014-2024
University Hospital Hradec Králové
2024
Charles University
2016-2024
University of Pardubice
2012-2019
University of Hradec Králové
2015-2017
Ministry of Education Youth and Sports
2016
Abstract We stratified post-COVID patients into four newly established clinical groups based on the presence or absence of at least one subjective respiratory symptom and objective sign pulmonary involvement. Nearly half outpatients third hospitalized had signs involvement without accompanying symptoms three months after diagnosis.
Abstract Diagnosis of SARS-CoV-2 virus is mainly based on direct detection. Determination specific antibodies has been used mostly for epidemiological reasons. However, select immunoassays showed good correlation to plaque reduction neutralization test (PRNT) in smaller patient cohorts, which suggests their potential as predictors titer. A total 3,699 samples from Covid-19 patients were included the multicentric study performed Czech Republic. Anti-SARS-CoV-2 antibody levels evaluated by 8...
An increasing resistance of microbes to antibiotics, the emergence multidrug-resistant and extremely resistant strains, long time needed develop new antibiotics are driving search for additional sources antibacterial agents. The aim study was compare efficacy Czech honeys with already available pharmaceutical agents containing medicinal honey, perform basic biochemical analysis samples, including detection undesirable chemical substances. results showed strong activity honeydew compared...
Abstract Quaternary ammonium salts belong to the group of cationic surfactants and their structure, especially length alkyl chain, plays a significant role in its activity against various microorganisms. Globally, there is growing need develop novel compounds due increasing resistance microorganisms antimicrobial agents. Three series quaternary based on dichained N ‐alkylammonium were synthesized with different carbon chain lengths (C 8 , C 10 12 14 16 ). These characterized analytical...
Clostridioides (C.) difficile is an important causative pathogen of nosocomial gastrointestinal infections in humans with increasing incidence, morbidity, and mortality. The available treatment options against this are limited. standard antibiotics expensive, can promote emerging resistance, the recurrence rate infection high. Therefore, there urgent need for new approaches to meet these challenges. One possible alternatives use compounds commonly used plants. In study, purified extracts...
The aim of this study was to evaluate the antimicrobial effects five natural substances against 50 clinical isolates Mycoplasma hominis.The in vitro activity selected compounds, cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene, investigated M. hominis cultivated from cervical swabs by broth dilution method. All showed valuable tested isolates. Oil Cinnamomum zeylanicum (MBC90 = 500 µg/mL) however found be most effective. Carvacrol 600 1000 also possessed strong antimycoplasmal...
The aim of this study was to investigate the antibacterial activity and toxicity for sperm cells natural substances gallic acid, methyl gallate, ethyl propyl octyl thymol, carvacrol eugenol. these selected combinations them against bacterial strains isolated from boar ejaculates determined using microdilution macrodilution method in Mueller-Hinton broth. most effective Gram-negative Gram-positive bacteria included our were thymol with minimum inhibitory concentration (MIC) values range...
Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts different lengths of alkyl chains (C12, C14, C16) were prepared by Menshutkin-like reaction and evaluated respect their biological activity, i.e., lipophilicity critical micellar concentration. C14 C16 side achieved similar or even better results when in terms efficacy...
Therapeutic regimens for the treatment of toxoplasmosis are not standardized. Treatment strategy mainly at end second and beginning third trimester, especially in cases negative prenatal diagnosis, is least uniform. In some situations, choice may be ambiguous, adverse drug reactions therapy should taken into consideration.Adverse anti-toxoplasma with spiramycin (n = 77) versus pyrimethamine/sulfadiazine 35) were compared 112 pregnant women.Up to 36.6% women reported overall 41). Out those...
Staphylococcus (S.) aureus is an important causative agent of wound infections with increasing incidence in the past decades. Specifically, emergence methicillin-resistant S. (MRSA) causes serious problems, especially nosocomial infections. Therefore, there urgent need to develop alternative or supportive antimicrobial therapeutic modalities meet these challenges. Purified compounds from hops have previously shown promising effects against MRSA isolates vitro. In this study, purified...
Benzoxonium chloride belongs to the group of quaternary ammonium salts, which have been widely used for decades as disinfectants because their high efficacy, low toxicity, and thermal stability. In this study, we prepared C10-C18 set benzoxonium-like salts evaluate effect chemical biological decontamination capabilities. particular, biocidal activity against a panel bacterial strains including Staphylococcus aureus in biofilm form was screened. addition, most promising compounds were...
The genus Enterococcus is represented by some of the clinically important species and well known for its antibiotic resistance, which participates in colonization infection.Increasing resistance enterococci has been evoked due to excessive use antibiotics not merely therapeutic purposes or indicated cases.One promising possibilities how reduce great amount utilize antimicrobial properties natural substances.Usnic acid a lichen compound possessing antibacterial activity against gram-positive...
Aside from the general population, COVID-19 pandemic has also affected a group of patients in palliative oncology care. In this study, long-term immune responses against SARS-CoV-2 after vaccination were monitored cohort This non-randomized, prospective, and open-label pilot study recruited Palliative Oncology Program included 147 patients, which 80 females (54.4%) 67 males (45.6%). The overall evaluation current health status, anti-S IgG titer, neutralizing antibodies using virus...
Increasing resistance to antibiotics, adverse effects of standard anti-cancer or anti-inflammatory treatments, tumour types resistant these treatments are leading a search for alternatives.One is the use natural products, such as bee venom, which have same better effect than products.Bee venom has been used treat number diseases thousands years.However, significant obstacle remains risk severe allergic reactions, can be caused by some more 100 substances contained in venom.Therefore,...
Group of viral hemorrhagic fevers (VHF) present a range disorders from relatively moderately serious to human life threatening entities whose mortality reaches high levels.There are classified as acute febrile diseases characterized by nausea, myalgia and fatigue, dominating with general alteration vessel permeability regulation.Symptoms bleeding often occur, particularly in severe cases which usually diffuse symptom injury rather than life-threatening condition.