A5076724425- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Education, Psychology, and Social Research
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Multiple and Secondary Primary Cancers
- Diet, Metabolism, and Disease
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Digestive system and related health
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Gastrointestinal motility and disorders
University Hospital Brno
2012-2025
Masaryk University
2011-2025
University of Ostrava
2014-2025
University Hospital Ostrava
2014-2023
GlaxoSmithKline (Belgium)
2021
Universities at Shady Grove
2021
Program for Appropriate Technology in Health
2021
Ocní klinika
2000-2019
University of Defence
2015-2017
Military Research Institute
2017
Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention.The Prevention Colorectal Sporadic Adenomatous Polyps trial was randomized, placebo-controlled, double-blind study the COX-2 inhibitor celecoxib given daily in single 400-mg dose. At 107 centers 32 countries, we randomly assigned 1561 subjects who had adenomas removed before enrollment receive (933...
Background and Study Aims: Invasive treatment for abdominal pain due to chronic pancreatitis may be either surgical or endoscopic, particularly in cases of ductal obstruction. To date, the data published on effectiveness these two forms therapy have been mostly retrospective, there no randomized studies. A prospective, study comparing surgery with endoscopy patients painful obstructive was therefore conducted. Patients Methods: Consecutive pancreatic duct obstruction were invited participate...
CONTENTS Introduction and epidemiologic features Clinical manifestations diagnosis Treatment options prevention practice List of Tables Table 1 infection with selected diarrheal pathogens 2 Assessment dehydration using the “Dhaka method” 3 Nonspecific antidiarrheal agents 4 Antimicrobial for treatment specific causes diarrhea Figures Figure Therapeutic approach to acute bloody in children Cascade acute, severe, watery diarrhea—cholera-like, severe dehydration. See above recipe home-made oral...
Approximately 10 years after vaccination with the recombinant zoster vaccine (RZV), an interim analysis of this follow-up study ZOE-50/70 trials demonstrated that efficacy against herpes remained high. Moreover, safety profile clinically acceptable, suggesting clinical benefit RZV in ≥50-year-olds is sustained up to years.
Abstract Background This ongoing follow-up study evaluated the persistence of efficacy and immune responses for 6 additional years in adults vaccinated with glycoprotein E (gE)-based adjuvanted recombinant zoster vaccine (RZV) at age ≥50 2 pivotal trials (ZOE-50 ZOE-70). The present interim analysis was performed after ≥2 (between 5.1 7.1 [mean] post-vaccination) includes partial data year (Y) 8 post-vaccination. Methods Annual assessments were against herpes (HZ) from Y6 post-vaccination...
There have been only a few studies dealing with the incidence of chronic pancreatitis published. Over last 80 years, original describing were undertaken, including in Scandinavia, Switzerland, Hungary and Poland. Incidence varied geographically, from 1.6 new cases per year among 100,000 inhabitants Switzerland to 23 Finland. The aetiology 70% all was alcoholic pancreatitis. Czech Republic is 7.9 year, similar that Denmark Germany, but higher than Poland or Switzerland. In our study, main...
Sedation rates may vary among countries, depending on patients' and endoscopists' preferences. The aim of this survey was to investigate the rate using premedication for routine diagnostic upper gastrointestinal (UGI) endoscopy in societies, members European Society Gastrointestinal Endoscopy (ESGE).We evaluated a multiple-choice questionnaire which e-mailed representatives national are ESGE. had 14 items referring practices each country representatives' units.The response 76% (34/45). In...
Aims In recent years, Europe has recorded an increase in the number of measles outbreaks despite implementation vaccination into National Immunization Programs. The Czech Republic introduced against Program 1969. aim this study was to determine seroprevalence IgG antibodies adults. Methods Our designed as a prospective, multicenter cohort study. Samples blood were taken from adults aged 18 years and over. Specific determined by ELISA method. Results A 1911 sera samples obtained. total...
Proton pump inhibitor (PPI) monotherapy is commonly continued for 3 weeks after Helicobacter pylori eradication with PPI-based triple therapy regimens to ensure duodenal ulcer (DU) healing. This randomized, double-blind, multicentre study evaluated whether only 1 week of the new PPI esomeprazole was sufficient high rates healing and H. eradication.A total 446 pylori-positive patients active DU received twice daily treatment 20 mg (n = 222) or omeprazole 224) in combination amoxicillin g...
Pancreatic carcinoma is a condition with late diagnosis and one for which there no effective screening method. One possible diagnostic approach of so-called early adenocarcinoma the identification systematic examination individuals at risk this condition. Between 1992 2005 we systematically observed 223 diagnosed chronic pancreatitis. In 14-year period performed classical biochemical tests, endoscopic ultrasound, CT scans ERCP. We also asked about number cigarettes smoked per year classified...
Objectives Cyclooxygenase-2 (COX-2) and tumor suppressor p53 are molecules that linked to the oncogenesis of pancreatic cancer. COX-2 represents a key modulatory molecule in inflammation carcinogenesis, is known be implicated positive regulation growth tumorigenesis. Abnormal expression common many human neoplasms including Recent studies demonstrated functional interactions between COX-2. The p53-dependent upregulation was proposed another mechanism by which could abate its own...
Chronic hepatitis C is curable disease. Low detection rate could be one of the reasons poor treatment uptake. It important to identify HCV prevalence and anti-hepatitis virus (HCV) positive patients in population by effective screening strategy such as risk-based or birth cohort programs. There are no national population-based estimates Czech Republic (CZ). The most recent seroprevalence survey determined a anti-HCV antibodies 0.2% (in 2001). aim study was determine HCV, viraemia genotype CZ...
Objectives To compare esomeprazole-based triple therapy with esomeprazole alone for the eradication of Helicobacter pylori (H. pylori), healing ulcer and prevention relapse in H. pylori-related gastric (GU) diseases. Methods In this double-blind study, 401 pylori-positive patients more than or equal to two GUs were randomized to: (20 mg) twice daily (bid) amoxicillin (1000 bid clarithromycin (500 (EAC) 1 week, followed by placebo 3 weeks (EAC placebo); EAC once (E20) E20); antimicrobials E20...
Diagnosis of pancreatic cancer (PC) in early stages is still challenging for gastroenterologists. The detection one the utmost importance successful therapy this malignancy. An accurate differential diagnosis focal lesions plays also an important role, whether it chronic pancreatitis from PC or autoimmune (AIP) PC. Raised serum immunoglobulin G4 (IgG4) levels to twice normal value are considered significant diagnostic features type 1 AIP. However, IgG4 can be increased patients with PC, but...