A5103201910- Oral health in cancer treatment
- Nausea and vomiting management
- COVID-19 Clinical Research Studies
- Head and Neck Cancer Studies
- Anesthesia and Sedative Agents
- COVID-19 diagnosis using AI
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Tracheal and airway disorders
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Global Health Care Issues
- Anesthesia and Pain Management
- Salivary Gland Tumors Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sleep and related disorders
- Neonatal Respiratory Health Research
- Circadian rhythm and melatonin
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Salivary Gland Disorders and Functions
- Vaccine Coverage and Hesitancy
- Veterinary Pharmacology and Anesthesia
Danish Medicines Agency
2020-2022
Copenhagen University Hospital
2014-2019
Hvidovre Hospital
2014-2017
Capital Region of Denmark
2017
Amager Hospital
2017
University of Copenhagen
2012
Abstract Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that machine learning (ML) models could be used to predict risks at different stages of management and thereby provide insights into drivers prognostic markers disease progression death. From a cohort approx. 2.6 million citizens in Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for disease; 3944 cases had least one positive test subjected further analysis. from the...
Abstract Purpose To describe the use of tramadol and other analgesics in Denmark focusing on impact media attention (June December 2017) regulatory actions (September 2017 January 2018) tramadol. Methods Using nationwide registries, we identified all adults who filled a prescription for from 2014 to 2019. We described incidence rates, prevalence proportions, total over time. also switching between analgesics, treatment duration, skewness drug use, doctor-shopping. Results From early until...
To assess the risk of adverse events associated with heterologous primary (two dose) and booster (three vaccine schedules for covid-19 Oxford-AstraZeneca's ChAdOx1-S priming followed by mRNA vaccines (Pfizer-BioNTech's BNT162b2 or Moderna's mRNA-1273) as compared homologous covid-19.Nationwide cohort study.Denmark, 1 January 2021 to 26 March 2022.Adults aged 18-65 years who received a schedule one two doses (with either mRNA-1273 vaccine) were adults (ie, dose v dose, three schedule).The...
The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and head neck cancer (HNC) patients oral mucositis. A containing 5, 10, 25 50 mg bupivacaine, respectively, administered as single dose 10 individuals, HNC mucositis multiple doses five HNC. Blood samples were collected for 6 hr from the 3 HNC, administration. plasma concentration-time profiles fitted pharmacokinetic models using nonlinear mixed-effects...
Abstract Objective Burning mouth syndrome (BMS) is a chronic oral pain condition with unknown aetiology but assumed to involve peripheral/central neuropathological and immune‐mediated inflammatory factors. We aimed at characterizing neurogenic profiles symptomatology of patients BMS based on response local anaesthetic lozenge. Methods Patients were divided into an Effect ( n = 13), No effect 8) or Unspecified 2) group according their lozenge pain. Inflammation was assessed in blood plasma...
Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was assess the effect of bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment lidocaine spray before UGE. Ninety-nine adult outpatients undergoing unsedated diagnostic UGE were randomized receive either (L-group, n = 51) or (S-group, 42). Primary objective assessment discomfort including acceptance reflex during L-group assessed...
A nonblinded parallel-group randomized controlled study investigated the efficacy and tolerability of repeated administration a bupivacaine lozenge (25 mg) as pain management for oral mucositis in head neck cancer patients add-on to standard systemic management.The primary end point was difference between intervention group (Lozenge group) Control daily mean scores cavity or pharynx (whichever higher).Fifty from 2 hospitals Denmark were 1:1 7 days treatment with lozenges (taken up every...
Introduction: Oral mucositis induces severe oral pain in head and neck cancer patients. There is at this point no effective treatment without considerable side effects. Objective: The aim of pilot study was to investigate reduction cavity pharynx patients with (HNC) mucositis, the location anesthetic effect, duration relief, after a single-dose administration 25 mg bupivacaine lozenge. Methods: Ten HNC suffering from were included. assessed on visual analogue scale (from 0 100 mm) baseline...
ABSTRACT Background Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that Machine Learning (ML) models could be used to predict risks at different stages of management (at diagnosis, hospital admission and ICU admission) thereby provide insights into drivers prognostic markers disease progression death. Methods From a cohort approx. 2.6 million citizens in the two regions Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for...