A5073490328- COVID-19 Clinical Research Studies
- Dermatology and Skin Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Sepsis Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- COVID-19 diagnosis using AI
- Atrial Fibrillation Management and Outcomes
- Diabetes and associated disorders
- Allergic Rhinitis and Sensitization
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmaceutical Practices and Patient Outcomes
- Psoriasis: Treatment and Pathogenesis
- Therapeutic Uses of Natural Elements
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and healthcare impacts
- Gestational Diabetes Research and Management
- Pharmaceutical Economics and Policy
- Chronic Disease Management Strategies
- Liver Disease Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Cardiac, Anesthesia and Surgical Outcomes
Copenhagen University Hospital
2020-2024
Steno Diabetes Centers
2023-2024
Frederiksberg Hospital
2020-2023
Leo Pharma (Denmark)
2018-2020
Novo Nordisk (Denmark)
2013-2019
Danish Medicines Agency
2017
Abstract Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that machine learning (ML) models could be used to predict risks at different stages of management and thereby provide insights into drivers prognostic markers disease progression death. From a cohort approx. 2.6 million citizens in Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for disease; 3944 cases had least one positive test subjected further analysis. from the...
Time-restricted eating (TRE) has been suggested to be a simple, feasible, and effective dietary strategy for individuals with overweight or obesity. We aimed investigate the effects of 3 months 10-h per-day TRE follow-up on bodyweight cardiometabolic risk factors in at high type 2 diabetes.
Atopic dermatitis (AD) is associated with high disease burden, a significant physical and social impact. However, the association between severity burden of disease, work productivity daily activities being one aspect, has not been well characterized. To investigate impact on among adults AD in Europe (France, Germany U.K.) U.S.A. The survey panel participants for this cross‐sectional internet‐based were sourced from population‐based National Health Wellness Survey (Europe 2016, 2015 2016)....
BackgroundBetter understanding of the relationship between atopic dermatitis (AD) severity and health‐related quality life (HRQoL) could help improve knowledge a more effective treatment for people with AD.
Plaque psoriasis has significant impact on patients' quality of life. Topical therapy is considered the treatment mainstay for mild-to-moderate disease according to guidelines. Calcipotriol/betamethasone dipropionate (Cal/BD) [0.005%/0.05%] aerosol foam indicated vulgaris in adults. Cal/BD trials demonstrated improved efficacy and similar safety this population. Psoriasis complicated by broad range presentation, variability therapeutic options; particularly decisions transition from topical...
Objective Type 2 diabetes is a chronic condition that continues to increase in prevalence the UK. Incretin-based therapies, including liraglutide and sitagliptin, provide adequate blood glucose control. Clinical trials have shown offers greater glycaemic control body weight reduction comparison sitagliptin. We aimed assess effectiveness of sitagliptin routine clinical practice. Materials methods designed conducted retrospective database analysis primary care using Practice Research Datalink...
To compare the short-term cost and effectiveness of calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam against nonbiologic systemics in psoriasis patients for whom oral systemic or topical therapy is considered appropriate seven European countries.Matching-adjusted indirect comparisons four-week PASI-75 responses Cal/BD were performed versus 12-week methotrexate, acitretin, fumaric acid esters (FAE) 16-week apremilast. Analyses took a payer perspective included drug, physician...
AimsThis retrospective, longitudinal study characterised 2430 adults (mean age 40.8 ± 16.1 years) with newly diagnosed type 1 diabetes (T1D) over the first 5 years of insulin treatment.MethodsData from year pre- and up to post-insulin initiation were extracted UK Clinical Practice Research Datalink (1990–2013). Baseline HbA1c, BMI Charlson comorbidity index (CCI) score compared data at 1, 2, 3 years.ResultsMean HbA1c decreased significantly baseline 95 32.8 mmol/mol (10.8 3.0%) 61 21.9 (7.7...
ABSTRACT Background Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that Machine Learning (ML) models could be used to predict risks at different stages of management (at diagnosis, hospital admission and ICU admission) thereby provide insights into drivers prognostic markers disease progression death. Methods From a cohort approx. 2.6 million citizens in the two regions Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for...
To identify PaCO2 trajectories and assess their associations with mortality in critically ill patients coronavirus disease 2019 (COVID-19) during the first second waves of pandemic Denmark.A population-based cohort study retrospective data collection.All COVID-19 were treated eight intensive care units (ICUs) Capital Region Copenhagen, Denmark, between March 1, 2020 31, 2021.Data from electronic health records extracted, latent class analyses computed based on up to 3 weeks mechanical...
Abstract Aim To explore the impact of type 2 diabetes (T2D), glycaemic control and use glucose‐lowering medication on clinical outcomes in hospitalized patients with COVID‐19. Materials Methods For all admitted to a hospital Capital Region Denmark (1 March 2020 1 December 2021) confirmed COVID‐19, we extracted data mortality, admission intensive care unit (ICU), demographics, comorbidities, laboratory tests from electronic health record system. We compared T2D without using Cox proportional...
Abstract not available. Disclosures: Study sponsored by LEO Pharma. Copyright 2018 SKIN
We aimed to characterize the in-hospital analgesic use among total hip or knee arthroplasty (THA TKA) patients, and identify possible drug-related challenges. identified 15 263 patients operated with a THA TKA between 1 January 2012 30 April 2016. The prevalence of users potential clinically relevant drug-drug interactions (DDIs), along readmission vs. without DDI, were calculated. A DDI was defined as combination (A) diuretic, an angiotensin-converting enzyme inhibitor angiotensin II...
Abstract Background and Aims Chronic kidney disease (CKD) is a frequent complication to diabetes. CKD associated with significantly increased risk of morbidity mortality among people It well known that the incidence progression differ between men women. Women are more likely get CKD, while have rapid disease. However, previous studies were based on small populations. We aimed investigate without in women type 2 diabetes (T2D). Method Secular age trends rates sex differences investigated...
Summary Previous studies on the prevalence of drug-drug interactions (DDIs) have largely been restricted to specific hospital departments. We identified common drug combinations and potential (pDDIs) in an entire population throughout 1 year. Frequently administered involved analgesics, cardiovascular medicines gastrointestinal medicines. The pDDIs among newly hospitalised patients was 2.6%. most were ibuprofen – paracetamol, pantoprazole paracetamol morphine paracetamol. Critical rare only...