BACKGROUND: Use of anabolic androgenic steroids (AASs) is associated with increased mortality, and case reports have suggested that some these deaths are due to cardiovascular disease. However, the epidemiology disease in AAS users still relatively unexplored. This study aimed measure incidence male compare rates those a cohort from general population matched by age sex. METHODS: Men sanctioned an antidoping program for use Danish fitness centers between 2006 2018 were included sex 50 times...

Abstract Background The lifetime prevalence of androgenic anabolic steroid abuse is estimated to be around 6% for men, but there limited knowledge about the side effects these drugs. Objective To investigate mortality and morbidity amongst users steroids (AAS). Methods In this retrospective matched cohort study, 545 male subjects tested positive AAS in Danish fitness centres during period 3 January 2006 1 March 2018. Subjects were with 5450 controls. addition, 644 men who sanctioned because...

This cohort study investigates mortality and cause of death among a large androgenic anabolic steroid users, compared with control group, in Denmark from January 3, 2006, to March 1, 2018.

Meningiomas frequently occur within the field of neuro-oncology, but it is unclear whether exogenous or imbalanced endogenous hormones are involved in pathophysiology. A previous case-control study found an almost 20-fold increase risk developing meningioma among users androgenic anabolic steroids. We, therefore, investigated this hypothesis.

BackgroundVarious inflammatory biomarkers show prognostic potential for multiple sclerosis (MS)-risk after clinically isolated syndromes. However, are often examined singly and their interrelation precise aspects of associated pathological processes remain unclear. Clarification these relationships could aid the appropriate implementation in clinical practice. ObjectiveTo investigate between inflammation, demyelination neurodegeneration acute optic neuritis to assess association measures MS...

Male gender is an important risk factor of central serous chorioretinopathy (CSC), and studies have explored the pathophysiological role androgens in CSC with conflicting results. In this study, we shed light on hot topic by exploring a large cohort male androgen abusers. This study included abusers identified through nationwide anti-doping test program across Danish fitness centers from January 3 2006 to March 1 2018. For each case, randomly sampled ten controls using registries. These were...

Summary This study investigates the adverse reactions observed in pulmonary medicine. We used data from Adverse Drug Event Manager (ADEM) of Capital Region Denmark 2013 to 2024. Antibiotic drugs were most common causes reported but with very different side effect profiles. a wide range signals related angioedema and Angiotensin Converting Enzyme (ACE) inhibitors as well interstitial lung disease nitrofurantoin methotrexate. These findings aligned existing literature. Although system captured...

This study investigated the 1-year risk of injuries and poisonings among anabolic androgenic steroid users compared with controls from general population. In a cohort conducted in Denmark, 1,189 were identified through national antidoping program matched 59,450 controls. Participants followed for 1 year. Data on hospital contacts, educational length, occupational status retrieved nationwide registries. The primary outcomes incidence poisonings. secondary differentiated between fracture...

Background: Optic neuritis is a good model for multiple sclerosis relapse, but currently no tests can accurately predict visual outcome. Objective: The purpose of this study was to examine whether cerebrospinal fluid (CSF) biomarkers tissue damage and remodelling (neurofilament light chain (NF-L), myelin basic protein, osteopontin chitinase-3-like-1) outcome after optic neuritis. Methods: We included 47 patients with as first demyelinating episode. Patients underwent tests, optical coherence...

Objective The purpose of this study was to investigate the psychiatric morbidity among men with abuse anabolic steroids. Methods design is a retrospectively matched cohort study. Five hundred and fourty-five males, who tested positive for steroids in Danish fitness centers during period January 3, 2006 March 1, 2018, were 5450 randomly chosen male controls. Data cross-referenced seven national registers pertaining information about education, employment status, comorbidity. Main outcomes...

Abstract Purpose Previous research has found that male users of androgens are diagnosed approximately twice as often with infertility. We therefore set out to investigate the fertility in men using androgens. Methods The study included 545 males who tested positive for an anti-doping test program Danish fitness centers during period from January 3, 2006, March 1, 2018. confirmed androgen were matched by birth year 5450 controls. followed this cohort 10 years prior testing until end follow-up...

We report a poisoning with paliperidone palmitate, once‐monthly, long‐acting injectable antipsychotic. The patient suffered from deep sedation and dystonia. She had been treated extended release intramuscular for several years received her last injection 8 days prior to admission. plasma was nearly five times higher than the upper reference range. Paliperidone is substrate of p‐glycoprotein we therefore aimed increase its elimination by inducing through treatment St John's wort. This seemed...

Modern healthcare requires clinicians to navigate through complex drug treatments. This review offers an overview of sources information which can be used for general medication prescription and challenging patient populations. Key considerations pregnant or breastfeeding patients, those with renal impairment, liver dysfunction are discussed. We also touch on adverse reactions interactions. Finally, about services from independent regional centers, that by clinicians, provided.

Abstract Background A link between androgen use and the risk of cancers, especially prostate breast cancer, has been suggested. The knowledge about a possible association is limited. Objective study aimed to investigate cancer incidence rates, particularly those related in male users compare them control group. Methods We included identified through nationwide anti‐doping testing program Danish fitness centers from 2006 2018. paired each case with 50 controls same age, selected randomly....

OBJECTIVE: To investigate whether exposure to tramadol during early pregnancy is associated with an increased risk of spontaneous abortion or major congenital malformations. METHODS: The study a nationwide cohort including all registered pregnancies in Denmark between January 1, 1997, and December 31, 2016. Danish National Prescription Register was used identify maternal tramadol. Pregnancies were matched without ratio up 1:4 using propensity scoring. primary outcomes Cox proportional...

In Brief OBJECTIVE: To investigate whether exposure to selective serotonin reuptake inhibitors (SSRIs) in early pregnancy is associated with miscarriage. METHODS: This was a nationwide cohort study identifying all registered pregnancies Denmark from 1997 2010. All births were identified using the Medical Birth Registry, and records of induced abortion or miscarriage gathered National Hospital Register. Data on SSRI use Prescription Cox proportional hazard regression models used calculate...

The adverse drug event manager of the Capital Region Denmark received a report 65-year-old male with type II diabetes and long-lasting treatment indapamide. In addition, he had history high consumption licorice. For 2 weeks, patient suffered from myalgia, which general practitioner suspected to be polymyalgia rheumatica referred him hospital. Initial blood samples revealed reduced potassium concentration 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) an elevated creatine kinase 18,400 IU/L...

The aim of this study was to estimate the occupational risks in relation multiple sclerosis (MS). immediate background for research our finding that there had been a high number critical illness insurance claims by patients diagnosed with MS within agricultural segment Danish pension fund.An open cohort. All payouts from 2002 2011 were continuously registered.PensionDanmark; one Denmark's largest funds.PensionDanmark insures more than 300 000 members Confederation Trade Unions against...

Interferon-beta has been suggested as a trigger of psoriasis, yet systematic investigation is lacking. This study aimed to assess the risk developing psoriasis following interferon-beta treatment, utilizing pharmaco-epidemiological approach investigate role in pathogenesis. We included all treatment-naïve patients with multiple sclerosis (MS) Denmark who initiated treatment for MS from January 1996 June 2023. These were compared control cohort treated other disease-modifying drugs. incidence...