A5076239329- Cerebrospinal fluid and hydrocephalus
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Dysraphism and Malformations
- Cerebrovascular and Carotid Artery Diseases
- Neonatal and fetal brain pathology
- Neurological Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Venous Thromboembolism Diagnosis and Management
- Ophthalmology and Eye Disorders
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Spaceflight effects on biology
- Advanced MRI Techniques and Applications
- Olfactory and Sensory Function Studies
- Advanced X-ray and CT Imaging
- Renal and Vascular Pathologies
- Neurological Complications and Syndromes
- Spinal Cord Injury Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ultrasound and Hyperthermia Applications
John Hunter Hospital
2016-2025
University of Newcastle Australia
2014-2025
UNSW Sydney
2022-2024
Croydon University Hospital
2023
Hunter Medical Research Institute
2005-2022
John Hunter Children's Hospital
2015
Hunter New England Local Health District
2014
Newcastle University
2011
Repatriation General Hospital
2008
Flinders University
2008
Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, an alternative thrombolytic agent.
It is unknown whether collateral vessel status, as seen on computed tomography angiography, can predict the fate of penumbral tissue identified perfusion and thereby influence clinical outcome. We tested this hypothesis in consecutive patients who underwent tomography/computed angiography within 6 h anterior circulation stroke, also had repeat perfusion/infarct volume imaging at 24 h, modified Rankin Scale 3 months. Collateral status was graded good or reduced depending extent contrast...
Many theories of normal pressure hydrocephalus (NPH) stress the importance ischemia in deep white matter. Alternate a reduction superficial venous compliance and changes pulse-wave propagation. An overlap cerebral blood flow volumes measured between NPH controls suggests that may not be prerequisite for this condition. This study sought to compare measures cohort patients with selected having arterial inflows above range see if brain or hemodynamic contribute pathophysiology NPH.
The use of perfusion imaging to guide selection patients for stroke thrombolysis remains controversial because lack supportive phase three clinical trial evidence. We aimed measure the outcomes treated with intravenous recombinant tissue plasminogen activator (rtPA) at a comprehensive care facility where computed tomography was routinely used eligibility decision assistance. Our overall hypothesis that 'target' mismatch on would have improved rtPA. This prospective cohort study consecutive...
<b>Objectives: </b> To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment cerebral perfusion to compare their rates progression infarction. <b>Methods: We assessed cortical regions NCCT for change. Quantitative values were calculated from acute (CTP) maps blood volume (CBV), flow (CBF), mean transit time (MTT). Reperfusion presence infarction determined follow-up MRI....
Tenecteplase is a modified tissue plasminogen activator with longer half-life and higher fibrin specificity than alteplase.We conducted prospective, nonrandomized, pilot study of 0.1 mg/kg IV tenecteplase given 3 to 6 hours after ischemic stroke onset. For control group, we used patients contemporaneously treated sub-3-hour 0.9 alteplase following standard selection criteria. All underwent pretreatment 24-hour perfusion/angiographic imaging CT or MRI. Eligibility criteria for (but not...
A collapsible segment in the venous outflow has been noted many patients with idiopathic intracranial hypertension (IIH). Mathematical modeling shown that these segments can account for elevated cerebrospinal fluid (CSF) pressures associated IIH. However, model required an resistance of up to 10 times normal predict CSF actually found clinically. Measurement blood flow IIH inflow rates vary, higher lesser stenoses. The aim this work was extend a simple cerebral hydrodynamics accommodate...
Background. Upper-limb (UL) dysfunction is experienced by up to 75% of patients poststroke. The greatest potential for functional improvement in the first month. Following reperfusion, evidence indicates that neuroplasticity mechanism supports this recovery. Objective. This preliminary study hypothesized increased activation putative motor areas those receiving intensive, task-specific UL training month poststroke compared with standard care. Methods. was a single-blinded, longitudinal,...
Background: In normal pressure hydrocephalus (NPH) there is blood–brain barrier (BBB) disruption, which should increase the CSF formation rate (CSFfr) and, therefore, also intracranial (ICP). However, ICP in NPH. A lumped parameter study was performed to look at interrelation between ICP, cerebral blood flow (CBF), and degree of BBB disruption The model suggested that CSFfr could be reduced this condition if moderated by a reduction capillary transmural (TMP) secondary arteriolar...
Increased cerebral blood flow pulsatility is common in vascular dementia and associated with macrostructural damage to white matter or leukoaraiosis (LA). In this study, we examine whether microstructural changes older adults no mild LA evidence of dementia. Diffusion Tensor Imaging was used measure fractional anisotropy (FA), an index the integrity matter, radial diffusivity (RaD), a sensitive myelin. When controlling for age, increased arterial pulsation deterioration both measures...
The lack of absorption CSF at the vertex in chronic hydrocephalus has been ascribed to an elevation arachnoid granulation outflow resistance (Rout). infusion studies measuring Rout are dependent on venous sinus pressure but little is known about changes which occur throughout life or with development hydrocephalus. Twenty patients underwent MR venography and flow quantification techniques. was estimated from blood cross-sectional area transverse sinuses. Adult controls as well a normal young...
It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which distinct from more obvious immune-mediated attack on white matter. Limited data exists indicating an alteration in pulse wave propagation within craniospinal cavity MS, similar to findings normal pressure hydrocephalus (NPH). hypothesized MS may harbor encephalopathy. The purpose this study compare blood flow and measurements patients with cohort NPH control...
Obstructive uropathy in the early stages can be difficult to diagnose using either standard sonography or arterial resistive index. We tested hypothesis that acute obstruction of renal collecting system reduces intraparenchymal compliance, which affects venous blood flow a greater degree than flow.Twelve patients with clinical evidence obstructive were referred for helical CT confirm diagnosis and provide gold by we could evaluate sonographic findings 12 test patients. Twelve without disease...