A5073508425- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Advanced MRI Techniques and Applications
- Cardiovascular and exercise physiology
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Assays
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
- Calpain Protease Function and Regulation
- Exercise and Physiological Responses
- Nutrition and Health in Aging
Maastricht University
2016-2025
University Medical Center
2019-2020
Maastricht University Medical Centre
2018
Abstract The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology remain unclear. In current study, we examined to what extent physical activity contributes health during aging compared young older adults, with similar habitual levels. We also studied exercise-trained adults physically impaired adults. Aging was associated a capacity, exercise capacity efficiency, gait stability, function, insulin sensitivity, even when...
The athlete’s paradox states that intramyocellular triglyceride accumulation associates with insulin resistance in sedentary but not endurance-trained humans. Underlying mechanisms and the role of muscle lipid distribution composition on glucose metabolism remain unclear. We compared highly trained athletes (ATHL) normal weight (LEAN) overweight-to-obese (OVWE) male female individuals. This observational study found ATHL show higher sensitivity, mitochondrial content, capacity, lower...
Hepatic steatosis is associated with poor cardiometabolic health, de novo lipogenesis (DNL) contributing to hepatic and subsequent insulin resistance. saturated fatty acids (SFA) may be a marker of DNL are suggested most detrimental in Here, we show cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that able distinguish the fractions SFA, mono- polyunsaturated healthy metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). positively SFA...
Resveratrol supplementation improves metabolic health in healthy obese men, but not patients with type 2 diabetes (T2D) when given as add-on therapy. Therefore, we examined whether resveratrol can enhance men at risk of developing T2D. Additionally, if stimulate brown adipose tissue (BAT). Thirteen male first degree relatives (FDR) T2D received (150 mg/day) and placebo for 30 days a randomized, controlled, cross-over trial. significantly improved ex vivo muscle mitochondrial function on...
BackgroundType 2 diabetes patients and individuals at risk of developing are characterized by metabolic inflexibility disturbed glucose homeostasis. Low carnitine availability may contribute to impaired tolerance. Here, we investigated whether supplementation improves flexibility insulin sensitivity in tolerant (IGT) volunteers.MethodsEleven IGT- volunteers followed a 36-day placebo- L-carnitine treatment (2 g/day) randomised, placebo-controlled, double blind crossover design. A...
Exercise training reduces intrahepatic lipid (IHL) content in people with elevated liver fat content. It is unclear, however, whether exercise IHL normal Here, we measured the effect of on and without nonalcohol fatty liver. We further changes insulin sensitivity hepatic energy metabolism. Eleven males nonalcoholic (NAFL) 11 body mass index-matched individuals (CON) completed a 12-wk supervised program. (proton magnetic resonance spectroscopy), maximal oxidative capacity (V̇o 2max ,...
Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined metabolic perturbations in patients with NAFL, T2DM, and control (CON) subjects normal intrahepatic lipid (IHL) content.A two-step (10 mU/m2 /min; 40 mU/m2/min) hyperinsulinemic-euglycemic clamp was performed 11 13 CON subjects, all matched BMI, aerobic fitness. IHL content measured using proton magnetic resonance spectroscopy. Because high variability T2DM patients, this...
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body homeostasis in rodents, likely via mTORC2-mediated signalling. However, human data on this topic is virtually absent. We here investigate the effects of two-weeks with clenbuterol (40 µg/day) control as well energy- substrate metabolism healthy young men (age: 18-30 years, BMI: 20-25 kg/m2) a randomised, placebo-controlled, double-blinded, cross-over study (ClinicalTrials.gov-identifier: NCT03800290). Randomisation...
Purpose Acetylcarnitine formation is suggested to be crucial in sustaining metabolic flexibility and glucose homeostasis. Recently, we introduced a method detect acetylcarnitine vivo with long TE 1 H‐MRS. Differences T relaxation time between lipids can exploited for additional lipid suppression subjects high myocellular levels. Methods Acquisition of spectra an inversion recovery sequence was alternated standard signal acquisition suppress short metabolite signals. A proof principle...
NADH and NAD
Background Low carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration is a model for simulating inflexibility in healthy, sensitive volunteers. Here, we hypothesized that co-infusion L-carnitine alleviate lipid-induced Methods In randomized crossover trial, eight young healthy volunteers underwent hyperinsulinemic-euglycemic clamps (40mU/m2/min) with simultaneous saline...