A5035038924- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Health Promotion and Cardiovascular Prevention
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Cardiovascular Health and Disease Prevention
- Obesity, Physical Activity, Diet
- Diabetes Management and Education
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Cardiovascular Health and Risk Factors
- Clinical practice guidelines implementation
- Consumer Attitudes and Food Labeling
- Metabolomics and Mass Spectrometry Studies
- Advanced Glycation End Products research
- Urban Transport and Accessibility
Unilever Foods Innovation Centre
2020-2024
Unilever (Netherlands)
2013-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2009-2020
The Health Council of the Netherlands
2020
Vrije Universiteit Amsterdam
2019
Amsterdam University Medical Centers
2019
Public Health Service of Amsterdam
2019
Amsterdam Public Health
2008-2018
Cancer Research And Biostatistics
2008-2010
University Medical Center
2007
<b>Objectives</b> To investigate the association between long term intake of individual saturated fatty acids (SFAs) and risk coronary heart disease, in two large cohort studies. <b>Design</b> Prospective, longitudinal study. <b>Setting</b> Health professionals United States. <b>Participants</b> 73 147 women Nurses’ Health Study (1984-2012) 42 635 men Professionals Follow-up (1986-2010), who were free major chronic diseases at baseline. <b>Main outcome...
To investigate the relationship among A1C, fasting plasma glucose (FPG), and 2-h postload in Dutch general population to evaluate results of using A1C for screening diagnosis diabetes.In 2006-2007, 2,753 participants New Hoorn Study, aged 40-65 years, who were randomly selected from Hoorn, Netherlands, underwent an oral tolerance test (OGTT). Glucose status (normal metabolism [NGM], intermediate hyperglycemia, newly diagnosed diabetes, known diabetes) was defined by 2006 World Health...
Hepatic steatosis is associated with poor cardiometabolic health, de novo lipogenesis (DNL) contributing to hepatic and subsequent insulin resistance. saturated fatty acids (SFA) may be a marker of DNL are suggested most detrimental in Here, we show cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that able distinguish the fractions SFA, mono- polyunsaturated healthy metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). positively SFA...
The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances β-cell function. GLP-1 receptor agonists (GLP-1 RAs) dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for treatment type 2 diabetes. Using Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114;...
OBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies U.S. men women. RESEARCH DESIGN AND METHODS We followed 83,648 women from Nurses’ Health Study (NHS) (1980–2012), 88,610 NHSII (1991–2013), 41,771 Professionals Follow-Up (HPFS) (1986–2012). Dietary data were collected every 2–4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified...
Air pollution may promote type 2 diabetes by increasing adipose inflammation and insulin resistance. This study examined the relation between long-term exposure to traffic-related air prevalence among 50- 75-year-old subjects living in Westfriesland, Netherlands. Participants were recruited a cross-sectional screening-study conducted 1998 2000. Exposure was characterized at participants' home-address. Indicators of land use regression modeled nitrogen dioxide (NO2) concentration, distance...
OBJECTIVE To identify distinct developmental patterns of diabetic retinopathy (DR) and assess the risk factor levels patients in these clusters. RESEARCH DESIGN AND METHODS A cohort 3,343 with type 2 diabetes mellitus (T2DM) monitored treated Diabetes Care System West-Friesland, Netherlands, was followed from to 6 years. Risk factors were measured, two-field fundus photographs taken annually graded according EURODIAB study group. Latent class growth modeling used DR over time. RESULTS Five...
Objective To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population ii) investigate whether are associated hypertriglyceridaemia alanine aminotransferase (ALT) as liver fat marker. Design A population-based study. Methods total 163 persons normal metabolism (NGM), 20 intermediate hyperglycaemia type 2 diabetes aged 40–65 years participated. Participants received a load on separate occasions. Glucagon-like peptide 1 (GLP-1),...
Individuals at high risk for chronic cardiometabolic disease (cardiovascular [CVD], type 2 diabetes, and kidney [CKD]) share many factors would benefit from early intervention. We developed a nonlaboratory-based risk-assessment tool identification of people risk.
OBJECTIVE—High proinsulin concentration may be a better predictor for cardiovascular disease (CVD) mortality than insulin concentration. Previous observations have been confounded by glucose tolerance status or lack of precision because high intraindividual variability. We investigated the longitudinal relation means duplicate measurements and with all-cause CVD in population-based cohort taking into account. RESEARCH DESIGN AND METHODS—Fasting post–75-g glucose-load (2-h) glucose, insulin,...
To investigate the associations of HbA1c, fasting glucose, and postload plasma glucose with 10-year fatal non-fatal cardiovascular disease (CVD) all-cause mortality in Caucasian individuals between 50 75 years age without diabetes.The risk CVD relation to HbA1cand levels was assessed Cox survival analysis 1674 non-diabetic a population-based cohort (Hoorn Study). Analyses were stratified according sex adjustments made for known factors. After full adjustment, HbA1c ≥ 6.0% significantly...
Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact interventions on risk diabetes incidence, we investigated size shape associations plasma glucose (FPG), 2 h post-load (2hPG), HbA1c, HOMA-IR with incident type mellitus.The study population included 1349 participants aged 50-75 years without at baseline (1989) from a population-based cohort in Hoorn, Netherlands. Incident was defined by WHO 2011 criteria or...
The aim of this study was to examine the relations between intakes total, saturated, mono-unsaturated, poly-unsaturated and trans fatty acids (SFA, MUFA, PUFA TFA), their dietary sources (dairy, meat plant) with markers type 2 diabetes risk. This a cross-sectional analysis baseline data 5675 non-diabetic, middle-aged participants Netherlands Epidemiology Obesity (NEO) study. Associations habitual intake fasting postprandial blood glucose insulin, Homeostatic Model Assessment Insulin...
There is substantial interest in dietary approaches to reducing postprandial glucose (PPG) responses, but the quantitative contribution of PPG longer-term glycemic control (reflected glycated hemoglobin, HbA1c) general population not known. This study quantified associations preprandial exposure, and variability with HbA1c estimated explained variance individuals without type 2 diabetes (T2D).Participants A1c-Derived Average Glucose (ADAG) T2D (n = 77) or non-insulin-treated HbA1c<6.5%...
Heart failure is common in individuals with type 2 diabetes, and early detection of at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations B-type natriuretic peptide (BNP) levels a non-heart range changes markers left ventricular (LV) function 2) possible effect modification by diabetes population-based cohort.