A. Mesut Erzurumluoglu
A5084476792- Genetic Associations and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Asthma and respiratory diseases
- Machine Learning in Healthcare
- Genetic and phenotypic traits in livestock
- Genomic variations and chromosomal abnormalities
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Air Quality and Health Impacts
- Health disparities and outcomes
- Smoking Behavior and Cessation
- Diabetes and associated disorders
- COVID-19 impact on air quality
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Receptor Mechanisms and Signaling
- COVID-19 Pandemic Impacts
- Genetics and Neurodevelopmental Disorders
- Renin-Angiotensin System Studies
- Chronic Disease Management Strategies
Boehringer Ingelheim (Germany)
2023-2025
University of Leicester
2016-2024
Digital Science (United States)
2024
Boehringer Ingelheim (Australia)
2024
MRC Epidemiology Unit
2020-2021
University of Cambridge
2020-2021
Addenbrooke's Hospital
2021
Wellcome Trust
2021
Medical Research Council
2020
University of Bristol
2014-2018
LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability complex traits diseases, partition this into functional categories, genetic correlation between different phenotypes. Because relies on summary level data, computationally tractable even for very large sample sizes. However, publicly available GWAS are typically stored in databases have formats, making it difficult apply correlations...
<h3>Background</h3> Given the effect of chronic diseases on risk severe COVID-19 infection, present pandemic may have a particularly profound impact socially disadvantaged counties. <h3>Methods</h3> Counties in USA were categorised into five groups by level social vulnerability, using Social Vulnerability Index (a widely used measure disadvantage) developed US Centers for Disease Control and Prevention. The incidence mortality from COVID-19, prevalence major conditions calculated relative to...
Elevated blood pressure is a major risk factor for cardiovascular disease and has substantial genetic contribution. Genetic variation influencing the potential to identify new pharmacological targets treatment of hypertension. To discover additional novel loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals sought significant evidence independent replication further 228 245 individuals. We report 6 signals association or near HSPB7 , TNXB LRP12...
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear (MT-nDNA). In CHARGEmtDNA+ Consortium, we studied associations mtDNA MT-nDNA with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation imputation variants was followed single-variant gene-based...
Abstract In absence of empirical research data, there has been considerable speculative hypothesis on the relationship between climatic factors (such as temperature and humidity) incidence Covid-19. This study analyzed data from 310 regions across 116 countries that reported confirmed cases Covid-19 by March 12, 2020, found temperature, humidity, wind speed were inversely associated with rate after adjusting for regional temporal trend in Covid-19, columnar density ozone, precipitation...
Cardiovascular risk factors have been implicated in the etiology of cerebral small vessel disease (CSVD); however, whether associations are causal remains unclear part due to susceptibility observational studies reverse causation and confounding. Here, we use mendelian randomization (MR) determine which cardiovascular likely be involved CSVD.We used data from large-scale genome-wide association European ancestry identify genetic proxies for blood pressure, lipids, body mass index (BMI), type...
Background: Mutations in the gene MTARC1 (mitochondrial amidoxime–reducing component 1) protect carriers from metabolic dysfunction–associated steatohepatitis (MASH) and cirrhosis. encodes mARC1 enzyme, which is localized to mitochondria has no known MASH-relevant molecular function. Our studies aimed expand on published human genetic data observe effects of modulation preclinical MASH models. Methods Results: We identified a novel structural variant deletion MTARC1, associated with various...
Primary ciliary dyskinesia (PCD) is an autosomal-recessive disorder characterized by impaired function that leads to subsequent clinical phenotypes such as chronic sinopulmonary disease. PCD also a genetically heterogeneous with many single gene mutations leading similar phenotypes. Here, we present novel causal gene, coiled-coil domain containing 151 (CCDC151), which has been shown be essential in motile cilia of animals and other vertebrates but its effects humans was not observed until...
Abstract Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability complex traits diseases, partition this into functional categories, genetic correlation between different phenotypes. Because relies on summary level data, computationally tractable even for very large sample sizes. However, publicly available GWAS are typically stored in databases have formats, making it...
There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic weight control type 2 diabetes (T2D) obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels raising coronary artery disease (CAD) risk, a potential safety concern for agonism. We therefore aimed quantitatively assess whether association between fasting CAD risk mediated via or instead result linkage disequilibrium...
Impaired lung function is predictive of mortality and a key component chronic obstructive pulmonary disease. Lung has strong genetic but also affected by environmental factors such as increased exposure to air pollution, the effect their interactions not well understood.
Males have greater cardiometabolic risk than females, though the reasons for this are poorly understood. The aim of study was to examine association between common Y chromosomal haplogroups and during early life.In a British birth cohort, we examined with trajectories factors from 18 years carotid-femoral pulse wave velocity, carotid intima media thickness left ventricular mass index at age 18. Haplogroups were grouped according their phylogenetic relatedness into categories R, I, E, J, G...
Advancements in long-read sequencing technology have accelerated the study of large structural variants (SVs). We created a curated, publicly available, multi-ancestry SV imputation panel by 888 samples from 1000 Genomes Project. This high-quality was used to impute SVs approximately 500,000 UK Biobank participants. demonstrated feasibility conducting genome-wide association studies at biobank scale using 32 disease-relevant phenotypes related respiratory, cardiometabolic and liver diseases,...