A5055485522- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Viral-associated cancers and disorders
- Cancer survivorship and care
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- COVID-19 Clinical Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- AI in cancer detection
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Glycosylation and Glycoproteins Research
- Radiology practices and education
- Cardiovascular Health and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Artificial Intelligence in Healthcare and Education
- COVID-19 and healthcare impacts
Hospital Universitario Puerta de Hierro Majadahonda
2015-2023
Universidad Autónoma de Madrid
2018-2019
University of Miami
2000
Background: Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders. These parameters incompletely account for substantial interindividual susceptibility to CCM. We hypothesized that rare variants in genes contribute Methods: studied 213 patients CCM from 3 cohorts: retrospectively recruited adults diverse cancers (n=99), prospectively phenotyped breast cancer (n=73), children acute myeloid leukemia (n=41)....
Bacterial infections may complicate the course of COVID-19 patients. The rate and predictors bacterial were examined in patients consecutively admitted with at one tertiary hospital Madrid between March 1st April 30th, 2020. Among 1594 hospitalized COVID-19, 135 (8.5%) experienced infectious events, distributed as follows: urinary tract (32.6%), bacteremia (31.9%), pneumonia (31.8%), intra-abdominal (6.7%) skin soft tissue (6.7%). Independent older age, neurological disease, prior...
Artificial intelligence (AI) has contributed substantially in recent years to the resolution of different biomedical problems, including cancer. However, AI tools with significant and widespread impact oncology remain scarce. The goal this study is present an AI-based solution tool for cancer patients data analysis that assists clinicians identifying clinical factors associated poor prognosis, relapse survival, develop a prognostic model stratifies by risk.We used from 5275 diagnosed...
Immune checkpoint inhibitors (ICIs) are a cornerstone in cancer treatment but they can induce immune-related adverse events (irAEs). Furthermore, patients with pre-existing autoimmune and/or inflammatory disease (AID) have been excluded from clinical trials. The objective of this study is to evaluate the efficacy and safety ICIs AID.This an observational, retrospective carried out at Medical Oncology Department Hospital Universitario Puerta de Hierro, Majadahonda, Madrid between January 2016...
Abstract The high cure rates of Hodgkin lymphoma (HL) make this oncological disease among those with the greatest number long‐term survivors. This single‐institution study including 383 HL patients up to 45 years follow‐up, analyses morbidity and mortality population after treatments in comparison overall Spanish population, investigates whether it has changed over time stratifying by periods time, as a consequence therapeutic optimization. median age was 34.8 (range 15–87) survival 30...
Hodgkin lymphoma (HL) is the paradigm of curable disease. This study analyzed overall survival (OS) patients with HL and compared their between decades expected a general population.The median follow-up was 22 years. The OS 33 incidence mortality rate for all causes 2 per every 100 year. our cohort at 10 years from diagnosis 76% (95% CI: 72-79) 52% 30 48-57). Overall SMR (1980-2013) 2,943 2,518-3,439). Excluding primary tumor as cause death, obtained 2,266 1,895-2,710). those diagnosed...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, despite their excellent therapeutic effect, these medications typically result in a broad spectrum of toxicity reactions. Immune-related cardiotoxicity is uncommon but can be potentially fatal, and its true incidence underestimated clinical trials. The aim this study to assess the identify risk factors for developing cardiac event patients treated with ICIs. We conducted single-institution retrospective study,...
Introduction: Madrid has been the epicenter of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Spain. We analyzed our experience with SARS-CoV-2 infected and cancer patients. Patients Methods: included patients from March 1 to April 30 2020 at Hospital Universitario Puerta de Hierro, Majadahonda, (Spain). The inclusion criteria were diagnosis infection made by reverse transcription polymerase chain reaction (RT-PCR) nasopharyngeal specimens who admitted hospital due...
Background: Up to date, there isn't current method or parameter that allows identifying long survivors in treatment with immunotherapy (IT) a simple and accessible way. We made prospective study of the usefulness quantifying circulating tumor cells (CTCs) CTCs/PDL1+ patients treated immunotherapy. Methods: Patients, diagnosed non-small cell lung cancer second-line IT were analyzed prospectively. CTCs from peripheral blood samples isolated by double density gradient immunomagnetic separation...
Abstract Nodular lymphocytic predominance Hodgkin lymphoma (NLPHL) is a very uncommon subtype of (HL), representing approximately 5% all HL cases, with an incidence 0.3/100,000 cases per year and unique characteristics which distinguish it from classic lymphoma. Given its low frequency, there lack prospective randomized studies to inform practice, the accumulated experience academic groups being main source relevant information for management these patients. Eighty‐five patients recruited by...
With the object of proving whether seqeuntial or alternate forms chemotherapy would be advantageous one over other in treating advanced breast cancer and with purpose evaluating two different anthracyclines at equimolecular doses above-mentioned alternating regimens, 250 patients who had received no prior chemo- hormonotherapy were entered a prospective randomized trial. Group A was administered 4-epiadriamycin cyclophosphamide for 8 courses, followed by 6 cycles CMF, medroxyprogesterone...
Background: Cancer therapy-induced cardiomyopathy (CCM) is associated with cumulative drug exposures and pre-existing cardiovascular disorders. These parameters incompletely account for substantial inter-individual susceptibility to CCM. We therefore hypothesised that rare variants in genes might contribute
Abstract OBJECTIVE Immune checkpoint inhibitors (ICI) are a cornerstone in cancer treatment but they can induce immune-related adverse events (irAEs). Furthermore, patients with pre-existing autoimmune and/or inflammatory disease (AID) have been excluded from clinical trials. The objective of this study is to evaluate the efficacy and safety ICI AID. METHODS This an observational, retrospective carried out at Medical Oncology Department Hospital Universitario Puerta de Hierro, Majadahonda,...