Adam Freeman
A5006620531- Mobile and Web Applications
- Mobile Agent-Based Network Management
- Service-Oriented Architecture and Web Services
- Distributed and Parallel Computing Systems
- Computational Physics and Python Applications
- Software System Performance and Reliability
- Web Applications and Data Management
- Software Engineering and Design Patterns
- Big Data and Business Intelligence
- Model-Driven Software Engineering Techniques
- Advanced Database Systems and Queries
- Scientific Computing and Data Management
- Advanced Computational Techniques and Applications
- Web Data Mining and Analysis
- Software Engineering Techniques and Practices
- Semantic Web and Ontologies
- Business Process Modeling and Analysis
- Engineering and Information Technology
- Multimedia Communication and Technology
- Software Engineering Research
- Parallel Computing and Optimization Techniques
- Cloud Computing and Resource Management
- Web Application Security Vulnerabilities
- Mathematics, Computing, and Information Processing
- Simulation Techniques and Applications
Hutchison/MRC Research Centre
2022-2024
University of Cambridge
2022-2024
Cancer Research UK Cambridge Center
2023-2024
University of Tampa
2023
Medical Research Council
2022
Wellcome Sanger Institute
2022
Milton Keynes Hospital
2013-2017
Press Association
2014
Springer Nature (United States)
2012-2014
McMaster University
2013
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal cases with matched samples patient-derived organoids disentangle complex their associated mechanisms. Short-read sequencing identifies ERBB2 , MYC MDM2, HMGA2 as most oncogenes amplified DNAs. We resolve...
Abstract A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore mutagenic shaping oesophageal adenocarcinoma tumorigenesis in 997 instances comprising distinct stages this malignancy, Barrett Oesophagus primary tumours and metastatic disease. The landscape is dominated by C[T > C/G]T substitution enriched signatures SBS17a/b, which linked with TP53...
Abstract Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched transcriptomes, we observed structural variations (SV) with a predominance deletions, tandem duplications and inter-chromosome junctions that could be identified as LINE-1 mobile element (ME) insertions. Complex clusters rearrangements resembling breakage-fusion-bridge cycles or extrachromosomal...
Abstract Background Personalising management of primary oesophageal adenocarcinoma requires better risk stratification. Lack independent validation proposed imaging biomarkers has hampered clinical translation. We aimed to prospectively validate previously identified prognostic grey-level co-occurrence matrix (GLCM) CT features for 3-year overall survival. Methods Following ethical approval, and contrast-enhanced data were acquired from participants five institutions. Data three institutions...
ABSTRACT CDKN2A is a tumour suppressor located in chromosome 9p21 and frequently lost Barrett’s oesophagus (BO) oesophageal adenocarcinoma (OAC). How other gene co-deletions affect OAC evolution remains understudied. We explored the effects of loss OACs cancer progressor non-progressor BOs with matched genomic, transcriptomic, clinical data. Despite its driver role, BO prevents initiation by counter-selecting subsequent TP53 alterations. predict poor patient survival but not through...
A common task in data analysis is to compare two or more sets of data, statistics, presentations, etc. predominant method use side-by-side visual comparison images. While straightforward, it burdens the user with discerning differences between The if further taxed when images are 3D scenes. This paper presents several methods for analyzing extent, magnitude, and manner which surfaces differ their attributes. surface geometry assumed be identical only attributes (color, texture, etc.)...