Faye Elliott
A5047882328- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- Skin Protection and Aging
- Melanoma and MAPK Pathways
- Vitamin D Research Studies
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- melanin and skin pigmentation
- Nonmelanoma Skin Cancer Studies
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Bone and Dental Protein Studies
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Cancer Diagnosis and Treatment
University of Leeds
2015-2025
St James's University Hospital
2013-2023
Institute of Molecular Medicine
2008-2023
Wellcome Trust
2023
Cancer Research And Biostatistics
2011-2016
Leeds Teaching Hospitals NHS Trust
2009-2012
Cancer Research UK
2007-2012
In-Q-Tel
2012
Royal Surrey County Hospital
2009-2012
University of Surrey
2012
Activating mutation of the KRAS oncogene is an established predictive biomarker for resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies in advanced colorectal cancer (aCRC). We wanted determine whether and/or BRAF also a other aCRC therapies.The Medical Research Council Fluorouracil, Oxaliplatin and Irinotecan: Use Sequencing (MRC FOCUS) trial compared treatment sequences including first-line fluorouracil (FU), FU/irinotecan or FU/oxaliplatin aCRC. Tumor blocks were...
Lynch syndrome is associated with an increased risk of colorectal cancer and a broader spectrum cancers, especially endometrial cancer. In 2011, our group reported long-term outcomes (mean follow-up 55·7 months [SD 31·4]) for participants enrolled into randomised trial daily aspirin versus placebo. This report completes the planned 10-year to allow longer-term assessment effect taking regular in this high-risk population.
Observational and epidemiologic data indicate that the use of aspirin reduces risk colorectal neoplasia; however, effects in Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplastic effect on colon.In a randomized, placebo-controlled trial, we used two-by-two design to investigate aspirin, at dose 600 mg per day, resistant (Novelose), 30 g reducing adenoma carcinoma among persons syndrome.Among 1071 43 centers, 62 were...
A cohort study was carried out to test the hypothesis that higher vitamin D levels reduce risk of relapse from melanoma.A pilot retrospective 271 patients with melanoma suggested may protect against recurrence melanoma. We tested these findings in a survival analysis 872 recruited Leeds Melanoma Cohort (median follow-up, 4.7 years).In study, self-reports taking supplements were nonsignificantly correlated reduced (odds ratio = 0.6; 95% CI, 0.4 1.1; P .09). Nonrelapsers had mean...
Purpose Candidate predictive biomarkers for irinotecan and oxaliplatin were assessed in 1,628 patients Fluorouracil, Oxaliplatin, CPT-11: Use Sequencing (FOCUS), a large randomized trial of fluorouracil alone compared with advanced colorectal cancer. Methods The candidate were: tumor immunohistochemistry MLH1/MSH2, p53, topoisomerase-1 (Topo1), excision repair cross-complementing gene 1 (ERCC1), O-6-methylguanine-DNA-methyltranserase (MGMT), cyclooxygenase 2 (COX2); germline DNA...
Abstract Evidence supporting aspirin and resistant starch (RS) for colorectal cancer prevention comes from epidemiologic laboratory studies (aspirin RS) randomized controlled clinical trials (aspirin). Familial adenomatous polyposis (FAP) strikes young people and, untreated, confers virtually a 100% risk of early death. We conducted an international, multicenter, randomized, placebo-controlled trial (600 mg/d) and/or RS (30 g/d) 1 to 12 years prevent disease progression in FAP patients 10 21...
Abstract Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder cancer, but the choice of which treatment would be most beneficial cannot currently predicted for individual patients. The primary aim this study was to assess whether expression any a panel DNA damage signaling proteins tumor samples taken before irradiation could used as predictive marker response, or rather prognostic. Protein MRE11, RAD50, NBS1, ATM, H2AX studied by immunohistochemistry...
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
<h3>Importance</h3> <i>RAS</i>wild-type (wt) status is necessary but not sufficient for response to anti-epidermal growth factor receptor (EGFR) agents in advanced colorectal cancer (aCRC). RNA expression of EGFR ligands epiregulin (EREG) and amphiregulin (AREG) may correlate with EGFR-targeted therapy efficacy aCRC, so represent a much-needed additional predictive marker these drugs. <h3>Objective</h3> To examine novel ligand model randomized clinical trial panitumumab, irinotecan,...
Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out large population-based case-control study to explore the environmental and genetic determinants relationship with risk.We report nevus phenotype in relation differing patterns sun exposure, inherited variation at loci shown recent genome-wide association studies be genes, risk.Increased numbers were associated holiday particularly on intermittently sun-exposed body sites (test for P(trend) < 0.0001)....
The aims of this study were to investigate the role vascular invasion (blood and lymphatic), vessel density presence tumour-associated macrophages as prognostic markers in 202 cutaneous melanoma patients. Sections primary stained with lymphatic-specific antibody D2-40 assess lymphatic intratumoural peritumoural areas; an against endothelial marker CD34 was used determine blood density, CD68 macrophage counts. Immunohistochemically determined (combined lymphatic) compared that using...
MicroRNAs (miRNAs) are involved in post-transcriptional regulation of gene expression through binding to messenger RNAs (mRNA) thereby promoting mRNA degradation or altered translation. A single-nucleotide polymorphism (SNP) located within a miRNA-binding site could thus alter translation and influence cancer risk treatment response. The common SNPs the 3′-untranslated regions 20 DNA repair genes were analysed for putative sites using bioinformatics algorithms, calculating difference Gibbs...
Gene expression studies in melanoma have been few because tumors are small and cryopreservation is rarely possible. The purpose of this study was to evaluate the Illumina DASL Array Human Cancer Panel for gene formalin-fixed primary identify prognostic biomarkers.Primary from two were sampled using a tissue microarray needle. Study 1: 254 cohort recruited 2000 2006. 2: 218 case-control patients undergoing sentinel node biopsy.RNA obtained 76% blocks; 1.4% samples failed analysis (transcripts...
Abstract The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants LS were randomized double-blind to 30 g (RS) daily or placebo for up 4 years. We present outcomes based planned 10-year follow-up from recruitment, supplemented by National Cancer Registry data 20 years England, Wales, Finland. Overall, 463 participants received RS 455 placebo. After follow-up, there was no difference colorectal (n...
To optimise predictive models for sentinal node biopsy (SNB) positivity, relapse and survival, using clinico-pathological characteristics osteopontin gene expression in primary melanomas. A comparison of the SNB positive negative cases was carried out 561 melanoma patients. In 199 patients, formalin-fixed tumours studied Illumina's DASL assay. cross validation approach used to test prognostic receiver operating characteristic curves were produced. Independent predictors positivity Breslow...