A5102930674- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- Endometriosis Research and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Cancer Treatment and Pharmacology
- Maternal and fetal healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Thermal Regulation in Medicine
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Cancer and Skin Lesions
- Vascular Tumors and Angiosarcomas
- Nutrition and Health in Aging
- Genital Health and Disease
- Cancer Risks and Factors
- Reproductive Health and Technologies
- Ectopic Pregnancy Diagnosis and Management
Cardiff University
2012-2023
Emory University
2020-2022
Winship Cancer Institute
2021
University of Kentucky
2018-2020
Chelsea and Westminster Hospital
2007
York General Hospital
2000
Abstract Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR) status its relation to BRAF mutation (BRAFMT) in metastatic colorectal cancer (mCRC). Experimental Design: A pooled analysis four phase III studies first-line treatment mCRC (CAIRO, CAIRO2, COIN, FOCUS) was performed. Primary outcome parameter hazard ratio (HR) for median progression-free survival (PFS) overall (OS) MMR BRAF. For analysis, Cox regression performed on individual patient data. Results:...
Abstract Purpose: Somatic mutation status at KRAS, BRAF, and NRAS is associated with prognosis in patients advanced colorectal cancer (aCRC); however, it remains unclear whether there are intralocus, variant-specific differences survival other clinicopathologic parameters. Experimental Design: We profiled 2,157 aCRCs for somatic mutations determined microsatellite instability status. sought inter- intralocus correlations between associations clinicopathology. Results: KRAS were rarely found...
32 Background: Previous data suggests the EGF ligands EREG/AREG may predict outcome of KRAS wt patients (pts) treated with cet in chemo-refractory setting but this finding has not been previously reported from first line randomised trials. Methods: FFPE samples primary tumours pts Arms A&B COIN trial Ox fluoropyrimidine (Fp) +/- were analysed for EGFR IHC, KRAS/NRAS/BRAF mutation and expression by RT-PCR. Ligand levels assessed against baseline data, prognostic markers as...
Much experimental evidence indicates that the adrenals possess a detoxicating function. Lewis showed double adrenalectomy increased sensitiveness of rats to cobra venom, adrenalin and diphtheria toxin. Scott Remonstrated greatly reduced resistance adrenalectomized animals doses killed streptococci staphylococci. Belding Wyman confirmed Lewis' work lowers Recently several investigators have found bacterial intoxication is conferred by cortical adrenal extract. Bradford extract seemed decrease...
Epithelial ovarian cancers (EOC) consist of several sub-types based on histology, clinical, molecular and epidemiological features that are termed "histo-types", which can be categorized into less aggressive Type I more II malignancies. This investigation evaluated the disease-specific survival (DSS) women with EOC using histo-type, grade, stage. A total 200,658 cases were identified in National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) data. Kaplan-Meier analyses,...
Background: Ovarian cancer (OC) is the leading cause of death from gynecologic malignancy and treated with a combination cytoreductive surgery platinum-based chemotherapy. Extended length stay (LOS) after can affect patient morbidity, overall costs, hospital resource utilization. The primary objective this study was to identify factors contributing prolonged LOS for women undergoing ovarian cancer. Methods: American College Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)...
3516 Background: Previous data suggest the EGF ligands EREG/AREG may predict outcome of KRAS wt patients (pts) in chemo-refractory setting but has not been previously reported from first line randomised trials. Methods: FFPE samples primary tumors pts Arms A&B COIN trial Ox fluoropyrimidine (Fp) +/- cet were analysed for EGFR IHC, KRAS/NRAS/BRAF mutation and expression by RT-PCR. Ligand levels assessed against baseline data, prognostic markers as uni/multivariate analyses predictive wild...
This study aimed to describe a novel surgical technique for the management of antenatally suspected placenta accreta spectrum (PAS).This is retrospective, case series patients with PAS undergoing peripartum hysterectomy reloadable articulating stapler at tertiary care center.Eighteen were identified and underwent aid stapler. Mean gestational age delivery was 344/7 ± 11/7 weeks. total operative time (skin-to-skin) 117.3 39.3 minutes, 79.8 19.8 minutes hysterectomy. blood loss entire 1,809...
Background: Hidradenocarcinoma is a malignant tumor of the cutaneous sweat glands. Vulvar lesions are rare, and their prognosis poor. Recurrence metastases common. Surgical excision with ipsilateral lymphadenectomy recommended. Case: A 47-year-old woman presented for consultation after surgical positive margins eccrine porocarcinoma vulva. The resultant right radical vulvectomy suggested low-grade without lymphovascular space invasion negative margins. Results: final diagnosis was invasive...
3561 Background: RAS mut status predicts lack of benefit from anti-EGFR agents in aCRC, but its impact on prognosis and chemotherapy outcomes is less clear. Previously we have reported that the poor BRAF cancer aCRC are due to accelerated decline following 1st-line progression, not chemoresistance. In same dataset perform a detailed analysis pts throughout treatment pathway help guide clinical decision-making this underserved population. Methods: was assessed tumors 2254 wild-type (wt) 3...
<div>Abstract<p><b>Purpose:</b> Genome-wide association studies have identified numerous loci associated with colorectal cancer risk. Several of these also been patient survival, although none validated. Here, we used large independent training and validation cohorts to identify robust prognostic biomarkers for cancer.</p><p><b>Experimental Design:</b> In our phase, analyzed 20 cancer-risk SNPs from 14 genome-wide loci, their effects on...
<div>Abstract<p><b>Purpose:</b> To determine the prevalence and prognostic value of mismatch repair (MMR) status its relation to <i>BRAF</i> mutation (<i>BRAF</i><sup>MT</sup>) in metastatic colorectal cancer (mCRC).</p><p><b>Experimental Design:</b> A pooled analysis four phase III studies first-line treatment mCRC (CAIRO, CAIRO2, COIN, FOCUS) was performed. Primary outcome parameter hazard ratio (HR) for...
Abstract CAR-T-cell therapies represent a new area of synthetic biology success in cancer immunotherapy. However, the complexity their adverse events related to activity are still major challenge. Using our in-house fully human computationally optimized phage display library, we established novel cell-based ultra-high throughput panning and screening CAR-T platform. Our proprietary vector is designed as series cassettes incorporating SuperHuman library with an optimal backbone. This allows...