A5048369598- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Dysphagia Assessment and Management
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Medical Imaging Techniques and Applications
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Reconstructive Surgery and Microvascular Techniques
- Oral Health Pathology and Treatment
- Management of metastatic bone disease
- Cancer survivorship and care
- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- Salivary Gland Disorders and Functions
The Netherlands Cancer Institute
2015-2024
Medical Cañada (Spain)
2020
Oncode Institute
2016
Consistent delineation of patient anatomy becomes increasingly important with the growing use highly conformal and adaptive radiotherapy techniques. This study investigates magnitude 3D localization interobserver variability organs at risk (OARs) in head neck area application guidelines, to establish measures reduce current redundant practice. Interobserver among five experienced radiation oncologists was studied a set 12 CT scans for spinal cord, parotid submandibular glands, thyroid...
9507 Background: Standard of care for locally advanced cutaneous SCC (CSCC) consists extensive and mutilating surgery often with adjuvant radiotherapy (RT). To improve clinical prospects these patients (pts), we tested efficacy neoadjuvant nivolumab (NIVO) plus ipilimumab (COMBO) in pts CSCC an indication or without RT. Methods: 40 T1-4N0-3M0 TxN1-3M0 and/or were needed to reach the primary objective this trial. Pts randomized ARM A: NIVO (3 mg/kg, weeks 0&2, N = 26) B: 0&2) + IPI...
Definitive concomitant cisplatin-based chemoradiotherapy (CRT) is the current gold standard for most patients with advanced stage head and neck squamous cell carcinoma (HNSCC) of pharynx larynx. Since previous meta-analysis on CRT outcomes in HNSCC have been reported, advances made radiotherapy techniques clinical management, while HPV-status has identified as a strong confounding prognostic factor oropharyngeal cancer. Here, we present real-world outcome data from large multicenter cohort...
Background: To assess the prevalence of chronic lymphedema and trismus in patients > 6 months after head neck cancer (HNC) treatment, to explore how severity these conditions correlates with body image quality life. Methods: The cross-sectional sample included 59 patients, treated for HNC between six three years ago. Physical measurements were performed presence external (<36 mm). Furthermore, participants completed two questionnaires regarding (BIS) life (UW-QoL V4). Results:...
Abstract Background and Objective Interstitial photodynamic therapy is a potentially important tool in the management of voluminous or deep‐seated recurrent head neck cancers. Study Design/Methods The described treatment algorithm this manuscript consists simulation, implantation light sources, verification, modification plan if necessary, illumination. tumor delineated on imaging sections (CT, MRI, and/or PET/CT) simulated by virtually introducing sources to volume specially modified...
IntroductionDuring a course of radiotherapy for head-and-neck-cancer (HNC), non-rigid anatomical changes can be observed on daily Cone Beam CT (CBCT). To objectify responses to these changes, we use decision support system (traffic light protocol). Action levels orange and red may lead re-planning. The purpose this study was evaluate how often re-planning done which led in subgroups patients treatment adaptation deemed necessary.Materials methodsA consecutive series 388 HNC were...
To report on the late toxicity and local control (LC) of head neck cancer patients treated with adaptive FDG-PET/CT response-guided radiotherapy (ADMIRE) dose escalation (NCT03376386).Between December 2017 April 2019, 20 stage II-IV squamous cell carcinoma larynx, hypopharynx or oropharynx were within ADMIRE study where (Week 2&4) was applied (total 70-78 Gy). Cisplatin cetuximab added to in case T3-4 and/or N2c disease. compare LC population, we used an external group (n = 67) consisting...
Evaluation of treatment results orthovoltage X-rays for a selection previously untreated favorable basal cell carcinomas (BCC) in the head and neck area concerning local control, cosmetic functional outcome, toxicity profile.A consecutive series patients with primarily treated BCCs who were irradiated by means Netherlands Cancer Institute Amsterdam between January 2000 February 2015 retrospectively evaluated.Two hundred fifty-three 232 X-rays. The control rates at 1, 3, 5 years this 98.9%,...
Background: Surgery is the golden standard for treating basal cell carcinomas. In case of positive tumor margins or recurrent disease, postoperative adjuvant salvaging therapy suggested to achieve good local control. Objective: To retrospectively report on control and toxicity radiotherapy by means orthovoltage X-rays residual carcinoma after surgery in head neck area. Methods: Sixty-six surgically resected carcinomas region were irradiated postoperatively at Netherlands Cancer Institute...