A5032909516- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Mycobacterium research and diagnosis
- Dental Radiography and Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Photodynamic Therapy Research Studies
- Infectious Diseases and Tuberculosis
- Nanoplatforms for cancer theranostics
- Histiocytic Disorders and Treatments
- Protein Tyrosine Phosphatases
- Cleft Lip and Palate Research
- Bone health and treatments
- Ear and Head Tumors
- Advanced Radiotherapy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Soft tissue tumor case studies
- Nonmelanoma Skin Cancer Studies
- Congenital Ear and Nasal Anomalies
- Peptidase Inhibition and Analysis
- Diverticular Disease and Complications
Amsterdam University Medical Centers
2019-2025
The Netherlands Cancer Institute
2016-2025
Academic Center for Dentistry Amsterdam
2011-2025
University of Amsterdam
2014-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2024
Vrije Universiteit Amsterdam
2024
Dutch Cancer Society
2024
University Medical Center
2021
AC Camargo Hospital
2017-2018
Amsterdam UMC Location University of Amsterdam
2014-2017
Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC) results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non-randomized phase Ib/IIa trial, 32 HNSCC patients are treated with 2 doses (in weeks 1 3) of immune checkpoint blockade (ICB) using nivolumab (NIVO MONO, n = 6, Ib arm A) or plus single dose ipilimumab (COMBO, 26, 6 B, 20 IIa) prior to surgery. Primary endpoints feasibility resect no later than week (phase Ib) primary tumor...
Fibro-osseous tumors of the craniofacial bones are a heterogeneous group lesions comprising cemento-osseous dysplasia (COD), cemento-ossifying fibroma (COF), juvenile trabecular ossifying (JTOF), psammomatoid (PsOF), fibrous (FD), and low-grade osteosarcoma (LGOS) with overlapping clinicopathological features. However, their clinical behavior treatment differ significantly, underlining need for accurate diagnosis. Molecular diagnostic markers exist subsets these tumors, including GNAS...
ABSTRACT Objective We investigated the presence of mycobacteria in oral cavity and oropharynx children with nontuberculous mycobacterial (NTM) cervicofacial lymphadenitis compared to negative controls. Our aim was evaluate whether oropharyngeal swab sampling could serve as a minimally invasive alternative diagnostic excised lymph node tissue or punctate. Methods Children who underwent surgery under general anesthesia due strong clinical suspicion NTM were enrolled this multicenter...
Purpose. It is assumed that osteosarcomas of the jaws mainly occur at older ages, whereas most prominent sites, is, long bones, are more affected ages <20. Jaw-localized tumors less malignant and have lower metastatic spread rates. Patients Methods. This study analyses nationwide data Dutch Cancer Registry on osteosarcoma during period from 1991 to 2010. Age-corrected incidence rates were calculated. Results. In 949, 38 patients had in maxilla 58 mandible. Median age for maxilla, mandible,...
Objective In case of close or positive resection margins after oncological in head and neck surgery, additional treatment is necessary. When conventional options are exhausted, photodynamic therapy (PDT) can play a role achieving clear margins. The purpose the current study was to evaluate clinical benefit PDT as adjuvant next surgery with time interval between on survival outcomes also investigated. Study Design Retrospective cohort analysis. Methods Adjuvant performed patients malignancy...
Abstract Background The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk regional failure. Bilateral ENI, as compared unilateral is associated higher incidence acute late radiation-induced toxicity subsequent deterioration quality life. Increasing evidence that contralateral failure (cRF) lateralized HNSCC very low (< 10%) suggests it can be justified treat selected unilaterally. This...
To examine health utilities in patients with cT1-2 oral cavity squamous cell carcinoma following different diagnostic and treatment modalities for the neck to investigate relation between shoulder morbidity utility.Cross-sectional survey.Two Dutch hospitals.Four subgroups of cancer who underwent watchful waiting, sentinel lymph node biopsy, elective supraomohyoid dissection or therapeutic modified radical dissection.Patients received EuroQol-5D-3L questionnaire disability questionnaire. Mean...
Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due their striking morphologic resemblance osteoblastomas peripheral skeleton, we set out determine whether cementoblastomas harbor same FOS rearrangements with overexpression c-FOS as has recently been described for osteoblastomas. In total, 16 were analyzed expression by immunohistochemistry and fluorescence situ hybridization (FISH). We observed strong diffuse staining 71% identified a...
Odontogenic myxoma is a rare, benign, and locally aggressive tumor that develops in the tooth-bearing areas of jaw. The molecular mechanisms underlying odontogenic myxomas are unknown no diagnostic markers available to date. aim this study was analyze DNA methylation copy number variations identify new signatures for decision-making. We collected cohort 16 from 2006 2021 located mandible (n = 10) maxilla 6) with formalin-fixed paraffin-embedded or fresh frozen tissue biopsy resection...