A5022866404- Head and Neck Cancer Studies
- Photodynamic Therapy Research Studies
- Head and Neck Surgical Oncology
- Nanoplatforms for cancer theranostics
- Salivary Gland Tumors Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Dental Radiography and Imaging
- Oral and Maxillofacial Pathology
- Reconstructive Surgery and Microvascular Techniques
- Sinusitis and nasal conditions
- Nonmelanoma Skin Cancer Studies
- Optical Imaging and Spectroscopy Techniques
- Genital Health and Disease
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Anatomy and Medical Technology
- Cancer Immunotherapy and Biomarkers
- Dysphagia Assessment and Management
- Trauma Management and Diagnosis
- Cleft Lip and Palate Research
- Tracheal and airway disorders
- Reconstructive Facial Surgery Techniques
- Lung Cancer Research Studies
- Voice and Speech Disorders
- Nasal Surgery and Airway Studies
The Netherlands Cancer Institute
2016-2025
Amsterdam University Medical Centers
2019-2024
Dutch Cancer Society
2024
Google (United States)
2024
Delft University of Technology
2022
Academic Center for Dentistry Amsterdam
2020
University of Amsterdam
2020
Manisa Celal Bayar University
2019
National Medical Research Center of Dentistry and Maxillofacial Surgery
2014
Erasmus MC
2011
Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC) results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non-randomized phase Ib/IIa trial, 32 HNSCC patients are treated with 2 doses (in weeks 1 3) of immune checkpoint blockade (ICB) using nivolumab (NIVO MONO, n = 6, Ib arm A) or plus single dose ipilimumab (COMBO, 26, 6 B, 20 IIa) prior to surgery. Primary endpoints feasibility resect no later than week (phase Ib) primary tumor...
Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order evaluate if how can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of hybrid tracer indocyanine green (ICG)-99mTc-nancolloid was evaluated a large cohort patients.A prospective trial conducted (n = 501 procedures) heterogeneous 495 patients with...
Three-dimensional (3D) ultrasound can assess the margins of resected tongue carcinoma during surgery. Manual segmentation (MS) is time-consuming, labour-intensive, and subject to operator variability. This study aims investigate use a 3D deep learning model for fast intraoperative in volumes. Additionally, it investigates clinical effect automatic segmentation. A No New U-Net (nnUNet) was trained on 113 manually annotated volumes carcinoma. The implemented mobile workstation clinically...
Abstract Background Interstitial photodynamic therapy (iPDT) can be an option in the management of locally recurrent base tongue cancer after (chemo)radiation treatment. The purpose current study was to develop a technique implant light sources into tumor tissue. Methods Twenty patients with previously irradiated cancers who were not candidates for salvage surgery or reirradiation refused these therapies included this study. treatment planning done on MRI. implanted using modified...
This ex-vivo study evaluates the feasibility of diffuse reflectance spectroscopy (DRS) for discriminating tumor from healthy tissue, with aim to develop a technology that can assess resection margins presence cells during oral cavity cancer surgery. Diffuse spectra were acquired on fresh surgical specimens 28 patients squamous cell carcinoma. The (400 1600 nm) detected after illuminating tissue source fiber at 0.3-, 0.7-, 1.0-, and 2.0-mm distances detection fiber, obtaining spectral...
Introduction Nasopharyngeal Carcinoma (NPC) is a major health problem in southern and eastern Asia. In Indonesia NPC the most frequent cancer head neck area. very sensitive to radiotherapy resulting 3-year disease-free overall survival of approximately 70% 80%, respectively. Here we present routine treatment results prospective study on top referral; university hospital Indonesia. Methods All patients presenting from September 2008 till January 2011 at ear, nose throat (ENT) department Dr....
Objective In case of close or positive resection margins after oncological in head and neck surgery, additional treatment is necessary. When conventional options are exhausted, photodynamic therapy (PDT) can play a role achieving clear margins. The purpose the current study was to evaluate clinical benefit PDT as adjuvant next surgery with time interval between on survival outcomes also investigated. Study Design Retrospective cohort analysis. Methods Adjuvant performed patients malignancy...
In penile squamous cell carcinoma (pSCC), primary surgery aims to obtain oncologically safe margins while minimizing mutilation. Surgical guidance provided by receptor-specific tracers could potentially improve margin detection and reduce unnecessary excision of healthy tissue. Here, we present the first results a prospective feasibility study for real-time intraoperative visualization pSCC using fluorescent mesenchymal–epithelial transition factor (c-MET) receptor targeting tracer...
Photodynamic therapy (PDT) of early stage oral cavity tumors have been thoroughly reported. However, statistical comparison PDT to the surgical treatment is not available in published literature. We identified and matched cohorts patients with cancers undergoing surgery (n = 43) 55) from a single institute experience. The groups are demographically had same pre-treatment screening follow-up schedule. Both consisted only thinner than 5 mm ensure comparability. endpoints were local disease...
Background and Objectives There is a clinical need to assess the resection margins of tongue cancer specimens, intraoperatively. In current ex vivo study, we evaluated feasibility hyperspectral diffuse reflectance imaging (HSI) for distinguishing tumor from healthy tissue. Study Design/Materials Methods Fresh surgical specimens ( n = 14) squamous cell carcinoma were scanned with two cameras that cover visible near‐infrared spectrum (400–1,700 nm). Each pixel image represents measure optical...
Abstract Background and Objective Interstitial photodynamic therapy is a potentially important tool in the management of voluminous or deep‐seated recurrent head neck cancers. Study Design/Methods The described treatment algorithm this manuscript consists simulation, implantation light sources, verification, modification plan if necessary, illumination. tumor delineated on imaging sections (CT, MRI, and/or PET/CT) simulated by virtually introducing sources to volume specially modified...
2575 Background: surgery w/wo adjuvant radiotherapy (RT) for (recurrent) advanced head and neck squamous cell carcinoma (HNSCC) results in 30-50% 5-year OS, indicating the need novel treatment options. In recurrent metastatic HNSCC nivolumab nearly tripled 2-year OS. Aiming at improving clinical outcome a curative setting, we tested feasibility of ± ipilimumab neoadjuvant to (salvage) RT. Methods: investigator-initiated phase-IB/II trial assess monotherapy (240 mg week 1&3: arm-A) or...
Intraoperative tumor identification (extension/margins/metastases) via receptor-specific targeting is one of the ultimate promises fluorescence-guided surgery. The translation fluorescent tracers that enable visualization forms a critical component in realization this approach. Ex vivo assessment surgical specimens after topical tracer application could help provide an intermediate step between preclinical evaluation and first-in-human trials. Here, suitability c-Met receptor as potential...