A5049450614- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Dental Radiography and Imaging
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Anatomy and Medical Technology
- Prostate Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Spectroscopy Techniques in Biomedical and Chemical Research
- Sinusitis and nasal conditions
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Medical Imaging and Analysis
- Non-Invasive Vital Sign Monitoring
- Infrared Thermography in Medicine
- Oral and Maxillofacial Pathology
- Nasal Surgery and Airway Studies
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
The Netherlands Cancer Institute
2015-2025
Barraquer Opthalmology Center
2023-2024
Universitat Autònoma de Barcelona
2024
Dutch Cancer Society
2024
Delft University of Technology
2022
Erasmus University Rotterdam
2002-2013
Erasmus MC
2002-2012
Rotterdam University of Applied Sciences
1999-2002
In-vivo optical spectroscopy and the determination of tissue absorption scattering properties have a central role in development novel diagnostic therapeutic modalities medicine. A number techniques are available for characterization visible near-IR region spectrum. An important consideration many these is reliability spectrum various constituents tissue. The availability accurate spectra range 600 to 1100 nm may allow concentration key such as oxy- deoxy-hemoglobin, water, lipids. objective...
We propose a comprehensive protocol for the performance assessment of photon migration instruments. The has been developed within European Thematic Network MEDPHOT (optical methods medical diagnosis and monitoring diseases) is based on five criteria: accuracy, linearity, noise, stability, reproducibility. This was applied to total 8 instruments with set 32 phantoms, covering wide range optical properties.
Diffuse-reflectance spectroscopy for measurement of the absorption and scattering coefficients biological tissue produces reliable results wavelengths from 650 to 1050 nm. Implicitly, this approach assumes homogeneously distributed absorbers. A correction factor is introduced inhomogeneous distribution blood concentrated in discrete cylindrical vessels. This extends applicability diffusion theory lower wavelengths. We present measurements vivo optical properties wavelength range 500-1060
Three-dimensional (3D) ultrasound can assess the margins of resected tongue carcinoma during surgery. Manual segmentation (MS) is time-consuming, labour-intensive, and subject to operator variability. This study aims investigate use a 3D deep learning model for fast intraoperative in volumes. Additionally, it investigates clinical effect automatic segmentation. A No New U-Net (nnUNet) was trained on 113 manually annotated volumes carcinoma. The implemented mobile workstation clinically...
Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant using a fibre-optic needle probe, correlated histological outcome core-needle biopsies taken from same location as measurements. yields information blood content, oxygenation, average micro-vessel diameter, beta-carotene concentration scatter slope. Our data show that is characterized by significant decrease oxygenation...
Objective In case of close or positive resection margins after oncological in head and neck surgery, additional treatment is necessary. When conventional options are exhausted, photodynamic therapy (PDT) can play a role achieving clear margins. The purpose the current study was to evaluate clinical benefit PDT as adjuvant next surgery with time interval between on survival outcomes also investigated. Study Design Retrospective cohort analysis. Methods Adjuvant performed patients malignancy...
We use spatially resolved diffuse remittance spectroscopy (DRS) for the measurement of absorption (µa) and reduced scattering (µ) coefficients normal malignant breast tissue in vivo during surgery. Prior to these measurements, linearity technique was evaluated on liquid optical phantoms. In addition, reproducibility in-vivo measurements determined a healthy volunteer. present results properties wavelength range from 600 1100 nm performed radical mastectomy. A total 24 patients were included...
Background and Objectives There is a clinical need to assess the resection margins of tongue cancer specimens, intraoperatively. In current ex vivo study, we evaluated feasibility hyperspectral diffuse reflectance imaging (HSI) for distinguishing tumor from healthy tissue. Study Design/Materials Methods Fresh surgical specimens ( n = 14) squamous cell carcinoma were scanned with two cameras that cover visible near‐infrared spectrum (400–1,700 nm). Each pixel image represents measure optical...
Abstract Background and Objectives Previous studies with PhotoDynamic Therapy (PDT) in bladder bronchi have shown that due to scattering reflection, the actually delivered fluence rate on surface a hollow organ can be significantly higher than expected. In this pilot study, we investigated differences between primary calculated actual measured during PDT of Barrett's Esophagus (BE) using 23 independent clinical measurements 15 patients. Study Design/Materials Methods A KTP‐dye module laser...
Abstract The objective of this study was to develop a light delivery and measurement device for photodynamic therapy (PDT) in the nasopharyngeal cavity, which achieves homogeneous reproducible fluence rate distribution target area provides proper shielding predefined risk areas. Materials Methods A flexible silicone applicator developed, incorporating dosimetry fibers. can be inserted through mouth fixed cavity. Tissue optical phantoms were prepared on basis properties measured vivo using...
Abstract Background and Objective Interstitial photodynamic therapy is a potentially important tool in the management of voluminous or deep‐seated recurrent head neck cancers. Study Design/Methods The described treatment algorithm this manuscript consists simulation, implantation light sources, verification, modification plan if necessary, illumination. tumor delineated on imaging sections (CT, MRI, and/or PET/CT) simulated by virtually introducing sources to volume specially modified...
The purpose of this study was to evaluate the feasibility electromagnetic (EM) navigation for guidance on osteotomies in patients undergoing oncologic mandibular surgery. Preoperatively, a 3D rendered model mandible constructed from diagnostic computed tomography (CT) images. Cutting guides and patient specific reconstruction plates were designed printed intraoperative use. Intraoperative registration performed using cone beam CT scan (CBCT). location tracked with an EM sensor fixated...
Previous dosimetric studies during photodynamic therapy (PDT) of superficial lesions within a cavity such as the nasopharynx, demonstrated significant intra- and interpatient variations in fluence rate build-up result tissue surface re-emitted reflected photons, which depends on optical properties. This scattering effect affects response to PDT. Recently, meta-tetra(hydroxyphenyl)chlorin-mediated PDT study malignancies paranasal sinuses after salvage surgery was initiated. These geometries...
Abstract Background Histopathological analysis often shows close resection margins after surgical removal of tongue squamous cell carcinoma (TSCC). This study aimed to investigate the agreement between intraoperative 3D ultrasound (US) margin assessment and postoperative histopathology resected TSCC. Methods In this study, ten patients were prospectively included. Three fiducial cannulas inserted into specimen. To acquire a motorized US volume, specimen was submerged in saline, which images...
Abstract Purpose This research aimed to develop an innovative method for designing and fabricating nasal prostheses that reduces anaplastologist expertise dependency while maintaining quality appearance, allowing patients regain their normal facial appearance. Methods The involved statistical shape modeling using a morphable face model 3D data acquired through optical scanning or CT. An automated design process generated patient-specific fits appearances regular prosthesis materials printing...