A5041859725- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Medical Imaging and Pathology Studies
- Meningioma and schwannoma management
- CAR-T cell therapy research
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Ophthalmology and Eye Disorders
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Hormonal and reproductive studies
- Heterotopic Ossification and Related Conditions
- Bone health and treatments
- IgG4-Related and Inflammatory Diseases
- Glycogen Storage Diseases and Myoclonus
- Hypothalamic control of reproductive hormones
- Intraoperative Neuromonitoring and Anesthetic Effects
- Liver Disease and Transplantation
- Spinal Dysraphism and Malformations
- Alcoholism and Thiamine Deficiency
ACS Medical College and Hospital
2024
Ashwini Hospital
2015-2023
Wellcome/MRC Institute of Metabolic Science
2013-2023
University of Cambridge
2011-2023
St Vincent Medical Center
2018-2019
St. Vincent's Medical Center
2019
Tamil Nadu Government Multi Super Speciality Hospital
2012-2017
Addenbrooke's Hospital
2009-2017
Wellcome Trust
2016-2017
Cedars-Sinai Medical Center
2014
Attainment of safe GH and IGF-1 levels is a central goal acromegaly management.
Subclinical hypercortisolism (SH) occurs in 5% to 30% of adrenal incidentalomas (AIs). Common screening tests for adrenocorticotropin-independent have substantial false-positive rates, mandating further time and resource-intensive investigations.To determine whether low basal dehydroepiandrosterone sulfate (DHEAS) is a sensitive specific test SH AI.In total, 185 patients with AI were screened medullary (plasma metanephrines) cortical [1 mg overnight dexamethasone suppression (ONDST), 24-hour...
Objective To determine if functional imaging using 11 C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. Design/methods Twenty-six patients persistent acromegaly after previous treatment, whom appearances were considered indeterminate, referred our centre for evaluation over a 4.5-year period....
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis. Although the majority of childhood ACC arises in context inherited cancer susceptibility syndromes, it remains less clear whether hereditary tumor predisposition exists for development adults. Here, we report first occurrence familial kindred Lynch syndrome resulting from pathogenic germline MSH2 mutation.A 54-year-old female history ovarian and colorectal was found to have an ACC. A detailed family revealed...
Summary Objective To develop an alternative method to immunoassay for the quantitative analysis of insulin‐like growth factor 1 ( IGF ‐1) using a mass spectrometry MS )‐based approach. Study design and patients A stable isotope dilution Ultra High Performance Liquid Chromatography tandem uHPLC ‐MS/MS)‐based quantification IGF‐1 was developed. The employed Selected Reaction Monitoring (SRM) two tryptic peptides derived from IGF‐1, utilised solid phase extraction enrichment peptide fraction...
Several studies have suggested an increased prevalence of benign and malignant tumors in acromegaly, particularly colonic neoplasms. The gallbladder's epithelial similarity to the colon raises possibility that gallbladder polyps (GBP) may occur more frequently acromegaly.Thirty-one patients with newly diagnosed acromegaly (14 females, 17 males; mean age 54.7 yr, range 27-76 yr) were referred our center between 2004 2008. All had pituitary adenomas treated somatostatin analogs prior...
This is the author accepted manuscript. The final version available from Endocrine Society via http://dx.doi.org/10.1210/jc.2015-3854
Sir, A 25-year-old woman presented with a 6-month history of headaches and galactorrhea, primary infertility 3-year duration. Endocrine assessment revealed modestly elevated serum prolactin level 96 ng/mL (reference range 2.5–29.2 ng/mL) normal thyroid function. T1-weighted contrast-enhanced magnetic resonance imaging (MRI) (Figure 1: Panels [cornonal] B [sagittal]) showed 4 mm hypointense lesion on the right side gland (arrow), typical microadenoma. She was commenced cabergoline 0.25 mg...
TPS463 Background: Pancreatic cancer has multiple mechanisms to prevent immune recognition that lead the creation of an suppressive tumor microenvironment. We hypothesize effective and sustained response against tumors requires a coordinated approach that: 1. reverses immune-suppressive microenvironment, 2. induces immunogenic cell death 3. reengages NK T-cell 4. cascade antigens. To test this hypothesis, we developed NANT Cancer Vaccine (NCV), which combines metronomic low-dose...
Acute shrinkage of a giant prolactinoma, masquerading as an erosive skull base tumour, with cabergoline
### Learning Point for Clinicians Hyperemesis gravidarum occurs in ∼1% of all pregnancies. One- to two-thirds these women develop gestational hyperthyroidism due β-human chorionic gonadotropin (β-hCG)- mediated activation the thyroid stimulating hormone (TSH) receptor. Thiamine has a limited storage pool only few weeks and an acute deficiency leading Wernicke’s encephalopathy can occur setting hyperemesis hyperthyroidism. An 18-year-old primigravida presented with fall at 16 gestation. She...
e15787 Background: Pancreatic cancer has multiple mechanisms to prevent immune recognition that lead the creation of an suppressive tumor microenvironment. We hypothesize sustained response against pancreatic requires a coordinated approach that: 1. reverses immune-suppressive microenvironment, 2. induces immunogenic cell death and 3. reengages NK T-cell 4. cascade antigens. To test this hypothesis, we have developed temporospatial combines metronomic low-dose chemotherapy, SBRT,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)