An objective evaluation of patient performance status (PS) is difficult because patients spend the majority their time outside clinic, self-report to providers, and undergo dynamic changes throughout treatment experience. Real-time, activity data may allow for a more accurate assessment PS physical function, while reducing subjectivity bias associated with current assessments. Consenting advanced cancer wore wearble monitor three consecutive visits in prospective, single-cohort clinical...

The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scale is commonly used by physicians and nurses in oncology, as it correlates with cancer morbidity, mortality, complications from chemotherapy can help direct clinical decisions prognostication. This retrospective cohort study aimed to identify whether ECOG-PS scores rated oncologist versus differ their ability predict outcomes.Over 19 months, 32 oncologists 41 a single academic comprehensive center independently scored...

Background: Heart failure (HF) in its chronic form is an irreversible and progressive disease. Palliative care (PC) interventions have traditionally been focused on patients with advanced cancer. We performed a pilot study to assess the feasibility of implementing American College Cardiology/American Association (ACC/AHA) guidelines for early PC intervention HF who were seeking or received potentially curative therapies. Methods: Twenty consecutive referred from heart transplant service...

Various neurodegenerative diseases involving brainstem structures as one of the main pathological lesions are reported to be associated with REM sleep behaviour disorder. Full blown disorder can diagnosed clinically, but motor dysfunction, a pathophysiological basis disorder, is difficult detect without all night polysomnography. Twenty consecutive patients multiple system atrophy no complaints nocturnal abnormal behaviours were clinically evaluated determine presence related symptoms. All...

Immigrants and refugees in the United States often face significant barriers accessing social services, including mental health support, legal assistance, ESL or related education, housing, vocational training, workforce resources, transportation, citizenship support. This article explores strengths challenges of community-based organizations welcoming centers (CBO WC) Illinois that serve these populations, people with disabilities, culturally appropriate inclusive ways. The Immigrant...

The use of artificial intelligence techniques has introduced a new dimension to the health-care sector, particularly in diagnosing diseases their early stages, allowing patients and workers take corrective action. study discusses machine learning algorithm created detect classify malnutrition preschool children. Malnutrition affects significant number children various nations, many whom are preschoolers. Early identification child will allow parents monitor child's health. model also...

Pancreatic cancer is the most lethal common with an estimated 5-year survival rate of 6-7% (across all stages). The only potential curative therapy surgical resection in those localized disease. Adjuvant (postoperative) confers a advantage over postoperative observation alone. Neoadjuvant (preoperative) offers to downstage initially unresectable tumors for resection, sterilize margins and decrease locoregional recurrence, identify subset patients aggressive disease whom surgery will not be...

To assess abnormal intracellular signal transduction in inclusion body myositis (IBM).Mitogen-activated protein kinases (MAPKs) play pivotal roles and regulate cell growth differentiation. Upon their activation, MAPKs translocate from the cytoplasm into nucleus.The authors investigated localization of several forms MAPK family-extracellular signal-regulated kinase (ERK), c-Jun N-terminal (JNK), p38 (p38)-in 10 patients with sporadic IBM 52 control subjects. The relationship between...

Appropriate ethical approval was obtained from our institution's review board before the study conducted.We searched computerised database for all arthroplasties performed hip fracture patients between 2005 and 2015.The inclusion criteria were estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m² with late-stage CKD (Stage 3-5); eGFR 15 or initiated renal replacement therapy ESRD.All managed preoperatively postoperatively by a nephrology team to optimise their medical condition...

Pancreatic ductal adenocarcinoma (PDAC) is associated with high symptom burden. However, treatment decisions currently depend heavily on physician interpretation of clinical parameters and may not consider patients' health preferences. The NIH Patient-Reported Outcomes Measurement Information System (PROMIS) initiative standardized a set patient-reported outcomes for use in chronic diseases. This study identifies preference rankings among patients PDAC physicians PROMIS domains compares the...

<b>Objective: </b> To integrate an immune-mediated mechanism and the disturbed protein expression in sporadic inclusion body myositis (IBM). <b>Background: In IBM, abnormal fibers harbor inclusions of some proteins found brains patients with Alzheimer disease (AD). Poly(A)-binding 1 (PABP1) is RNA binding that attaches to poly(A) tail mRNA involved translation degradation. Under stresses, combined PABP1 forms cytoplasmic granules called stress granules. <b>Methods: Using 12 muscle biopsies...

TPS463 Background: Pancreatic cancer has multiple mechanisms to prevent immune recognition that lead the creation of an suppressive tumor microenvironment. We hypothesize effective and sustained response against tumors requires a coordinated approach that: 1. reverses immune-suppressive microenvironment, 2. induces immunogenic cell death 3. reengages NK T-cell 4. cascade antigens. To test this hypothesis, we developed NANT Cancer Vaccine (NCV), which combines metronomic low-dose...

Colchicine has been used therapeutically for gout more than 200 years. Recently, the drug also autoimmune diseases such as Behcet disease. However, long-term use of colchicine can cause vacuolar myopathy.1,2⇓ Concomitant cyclosporin or renal insufficiency exaggerates toxic effect colchicine.1,2⇓ myopathy sometimes occurs in organ transplant recipients, although it may be unrecognized.3 inhibits polymerization microtubules by interacting with tubulin, a monomeric component microtubules. As...

e21689 Background: Patients with advanced cancer experience significant distress. Timely identification and treatment of distress can improve outcomes quality life. Domains (i.e. pain, fatigue, physical function) be assessed using patient reported outcome (PRO) questionnaires. However, PROs burdensome to patients, particularly when performed serially. Given the relationship between activity sleep domains distress, wearable monitors may assist in real-time detection patients. Methods: We...

Background and Purpose: The primary purpose of this study was to determine the predictive capacity hand grip strength on overall survival among patients undergoing hematopoietic stem cell transplantation (HCT). Design: Retrospective chart review. Setting: Hand measured at time HCT in an inpatient setting 2009. Patients: Forty-nine with various hematologic malignancies. Intervention: performed using dominant hand. Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-F) administered...

6571 Background: Performance status (PS) is assessed to inform treatment decisions and predict outcomes in cancer. PS often evaluated using ECOG or KPS scales, limited by their subjective static nature. Wearable activity monitors provide oncologists with the opportunity obtain continuous objective data on patients’ daily including steps, stairs climbed, sleep. We association between wearable monitor data, PS, clinical outcomes. Methods: Patients advanced cancer were enrolled a prospective,...