Patrick O’Neal

ORCID: 0000-0002-2943-3737
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Diversity and Career in Medicine
  • Muscle Physiology and Disorders
  • Surgical Simulation and Training
  • Exercise and Physiological Responses
  • Parathyroid Disorders and Treatments
  • Mentoring and Academic Development
  • Bacillus and Francisella bacterial research
  • Genetic Syndromes and Imprinting
  • Zoonotic diseases and public health
  • Disaster Response and Management
  • Curcumin's Biomedical Applications
  • Medical Imaging and Pathology Studies
  • Muscle metabolism and nutrition
  • Hospital Admissions and Outcomes
  • Health and Medical Research Impacts
  • Public Health Policies and Education
  • Innovations in Medical Education
  • Healthcare Policy and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Surgical site infection prevention
  • Adipose Tissue and Metabolism
  • Viral Infections and Outbreaks Research
  • Global Security and Public Health
  • FOXO transcription factor regulation
  • Airway Management and Intubation Techniques

Georgia College & State University
2024

University of Georgia
2024

VA Boston Healthcare System
2016-2021

Boston Medical Center
2019-2021

Boston University
2016-2021

Brigham and Women's Hospital
2012-2020

Georgia Department of Public Health
2006-2018

Western University of Health Sciences
2016

Beth Israel Deaconess Medical Center
2007-2011

Harvard University
2007-2010

We tested the hypothesis that treatment of rats with curcumin prevents sepsis-induced muscle protein degradation. In addition, we determined influence on different proteolytic pathways are activated in septic (i.e., ubiquitin-proteasome-, calpain-, and cathepsin L-dependent proteolysis) examined role NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>κ</mml:mi></mml:math>B p38/MAP kinase inactivation curcumin-induced inhibition breakdown. Rats were made by cecal...

10.1155/2008/317851 article EN cc-by Mediators of Inflammation 2008-01-01

This survey study explores how retired surgeons reflect on their careers and attitudes toward career decisions.

10.1001/jamasurg.2019.5476 article EN JAMA Surgery 2020-01-22

Muscle wasting during sepsis is at least in part regulated by glucocorticoids and associated with increased transcription of genes encoding the ubiquitin ligases atrogin-1 muscle-specific RING-finger protein-1 (MuRF1). Recent studies suggest that muscle atrophy caused denervation reduced expression nuclear cofactor peroxisome proliferator-activated receptor-γ coactivator (PGC)-1β PGC-1β may be a repressor MuRF1 genes. The influence other muscle-wasting conditions on not known. We tested...

10.1152/ajpendo.00596.2009 article EN AJP Endocrinology and Metabolism 2010-07-20

Abstract Muscle wasting is commonly seen in patients with hyperthyroidism and mainly caused by stimulated muscle proteolysis. Loss of mass several catabolic conditions associated increased expression the muscle‐specific ubiquitin ligases atrogin‐1 MuRF1 but it not known if are upregulated hyperthyroidism. In addition, thyroid hormone increases activity proteolytic mechanisms other than ubiquitin–proteasome pathway. We tested hypotheses that experimental rats, induced daily intraperitoneal...

10.1002/jcb.22329 article EN Journal of Cellular Biochemistry 2009-09-23

Responding to agricultural bioterrorism with pathogenic agents that are communicable from animals humans (zoonotic diseases) requires effective coordination of many organizations, both inside and outside government. Action must be simultaneously taken address public health concerns, respond the dimensions event, carry out necessary law enforcement investigation. As part a project focused on examining preparedness in Georgia, an exercise was carried July 2005 intentional introduction avian...

10.1089/bsp.2006.4.287 article EN Biosecurity and Bioterrorism Biodefense Strategy Practice and Science 2006-09-01

Academic institutions possess tremendous resources that could be important for community disaster response and preparedness activities. In-depth exploration of the role academic in has elicited information about particular leveraged essential to response; factors contribute decision-making process partner engagement; facilitators barriers sustainable collaborations from perspectives institutions, public health emergency management agencies, national association agency leaders. The...

10.5055/ajdm.2014.0146 article EN American Journal of Disaster Medicine 2014-04-01

Objective: Our study evaluated the willingness of retired surgeons to mentor newly trained surgeons. Summary Background Data: Although mentoring is very important during transition in practice, many novice are faced with inadequacy or lack mentoring. Methods: A survey regarding mentorship new was sent April 2018 general, colorectal, vascular, and cardiothoracic that members American College Surgeons. The analysis data performed September October 2018. Results: total 2295 5282 surveys were...

10.1097/sla.0000000000003272 article EN Annals of Surgery 2019-03-20

In response to the 2014 Ebola virus disease (EVD) outbreak in West Africa, Georgia Department of Public Health developed Infectious Disease Network (IDN) based on an EVD preparedness needs assessment hospitals and Emergency Medical Services (EMS) providers. The network consists 12 16 EMS providers with staff specially trained provide a coordinated utilize appropriate personal protective equipment (PPE) for transport or treatment suspected confirmed serious communicable patient. To become...

10.1017/dmp.2017.149 article EN Disaster Medicine and Public Health Preparedness 2018-02-02

Background: Although successful retirement planning improves the well-being of retiring surgeons and facilitates effective succession strategies, status mentoring in academic surgery remains unknown. The present study was designed to evaluate presence for departments United States.

10.26502/jsr.10020022 article EN Journal of Surgery and Research 2019-01-01

We tested the hypothesis that treatment of rats with curcumin prevents sepsis‐induced muscle protein degradation. In addition, we determined influence on different proteolytic pathways are activated in septic (i.e., ubiquitin‐proteasome‐, calpain‐, and cathepsin L‐dependent proteolysis) examined role NF‐ κ B p38/MAP kinase inactivation curcumin‐induced inhibition breakdown. Rats were made by cecal ligation puncture or sham‐operated. Groups treated three intraperitoneal doses (600 mg/kg)...

10.1155/mi/2008/317851 article EN cc-by Mediators of Inflammation 2008-01-01

Abstract Public Health is essential to disaster preparedness, mitigation, response, and recovery. This has never been more evident than during the COVID-19 pandemic when public health was response lead. However, students are graduating from accredited schools colleges of with limited or no education in management. a crisis unto itself, it incumbent upon The Council on Education for (CEPH) take immediate action. preparedness should be recognized as core element curricula, practical...

10.1017/dmp.2024.274 article EN Disaster Medicine and Public Health Preparedness 2024-01-01
Coming Soon ...