A5101965855- Vector-Borne Animal Diseases
- Pain Mechanisms and Treatments
- Animal Disease Management and Epidemiology
- Pancreatic function and diabetes
- Advanced Glycation End Products research
- Vector-borne infectious diseases
- Streptococcal Infections and Treatments
- Lysosomal Storage Disorders Research
- Animal Virus Infections Studies
- Neonatal and Maternal Infections
- Neuroendocrine Tumor Research Advances
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Veterinary Equine Medical Research
- Infective Endocarditis Diagnosis and Management
- T-cell and Retrovirus Studies
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Infectious Diseases and Mycology
- Natural Antidiabetic Agents Studies
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Diet, Metabolism, and Disease
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
Niigata University
2024
Nippon Medical School
2014-2019
Hirosaki University
2003-2014
Japan Racing Association
1989-2005
Mitsui (Japan)
2005
Kitasato University
1997-2005
University of Kentucky
2005
Tochigi Medical Center
2003
National Institute of Diabetes and Digestive and Kidney Diseases
2001-2002
National Institutes of Health
1999-2002
Inherited defects in the degradation of glycosphingolipids (GSLs) cause a group severe diseases known as GSL storage disorders. There are currently no effective treatments for majority these We have explored new treatment paradigm, substrate deprivation therapy, by constructing genetic model mice. Sandhoff's disease mice, which abnormally accumulate GSLs, were bred with mice that blocked their synthesis GSLs. The simultaneous and longer accumulated had improved neurologic function, much life...
Gaucher disease, the most common lysosomal storage is caused by a deficiency of glucocerebrosidase resulting in impairment glucosylceramide degradation. The hallmark disease presence cell, macrophage containing much stored found tissues, which believed to cause many clinical manifestations disease. We have developed adult mice carrying L444P point mutation (Gba) gene and exhibiting partial enzyme deficiency. mutant demonstrate multisystem inflammation, including evidence B cell...
Gaucher disease, the most common lysosomal storage is caused by a deficiency of glucocerebrosidase resulting in impairment glucosylceramide degradation. The hallmark disease presence cell, macrophage containing much stored found tissues, which believed to cause many clinical manifestations disease. We have developed adult mice carrying L444P point mutation (Gba) gene and exhibiting partial enzyme deficiency. mutant demonstrate multisystem inflammation, including evidence B cell...
Abstract Pioglitazone, one of thiazolidinediones, a peroxisome proliferator‐activated receptor (PPAR)‐γ ligand, is known to have beneficial effects on macrovascular complications in diabetes, but the effect diabetic neuropathy not well addressed. We demonstrated expression PPAR‐γ Schwann cells and vascular walls peripheral nerve then evaluated pioglitazone treatment for 12 weeks (10 mg/kg/day, orally) streptozotocin‐diabetic rats. At end, improved conduction delay rats without affecting...
A primary enzootic of equine Getah virus infection involving 722 1,903 racehorses occurred at a training center in Japan between September and November 1978. Sixty-two viral agents were isolated from the plasma 209 sick horses which exhibited pyrexia with rectal temperatures ranging 38.5–40°C, urticarial rash on various portions body, edema hind legs. The viruses antigenically related to AMM 2021, Haruna, Sagiyama strains virus. Infection disease produced experimentally when inoculated by...
Nonenzymatic glycation of neural proteins and their end-products (advanced end-products, AGE) have been implicated in the pathogenesis diabetic neuropathy. We need a development effective ant-glycation agents for future clinical use.We examined effects OPB-9195 (OPB), new inhibitor glycation, on peripheral nerve structure function rats. Eight-week-old Wistar rats were made by streptozotocin (40 mg kg(-1), i.v.) OPB (60 kg(-1) day(-1)) was given gavage 24 weeks. Age- sex-matched normal used...
To investigate the emergence of rifampin resistance in Rhodococcus equi strains isolated from foals and their environment Japan, we compared vitro antimicrobial susceptibilities to 640 isolates 64 infected 98 soil horse-breeding farms. As a control, 39 human patients with without AIDS were also tested for susceptibility rifampin. All showed sensitivity, except one foal two that resistance. rifampin-resistant R. foal, which had received monotherapy month before euthanasia, 99 lesions 20...
To develop a method for typing Streptococcus equi on the basis of DNA sequence genes that produce an M-like protein and to compare isolates among United States, Japan, other countries.S strains CF32, Hidaka/95/2, NCTC9682 as well 82 from countries obtained during 1975 2001.DNA sequences structural ( SeM SzPSe) proteins were determined 3 representative find variable region. Variability in this region was then isolates. Amino acid deduced analyzed phylogenetically by use neighbor-joining...
We studied the functional consequences of an enhanced polyol pathway activity, elicited with galactose feeding, on peripheral nerve transgenic mice expressing human aldose reductase. Nontransgenic littermate were used as controls. With a quantitative immunoassay, expression level reductase in sciatic was 791 ± 44 ng/mg protein (mean SE), about 25% that sural nerve. When fed food containing 30% galactose, significant levels galactitol accumulated Galactose feeding nontransgenic led to 10-fold...
Survey of rotavirus was conducted in 40 fecal samples which were divided into 4 groups according to diarrheal conditions clarify the relationship between and foals with diarrhea. Particles characteristic directly detected by electron microscopy from 5 14 collected acute Moreover, rotaviruses isolated MA-104 cells trypsin treatment, capable being successively passaged these cells. On other hand, no 26 various non-acute In cross serum neutralization test, strains antigenically recognized as...