A5085178268- Renal and related cancers
- Migraine and Headache Studies
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Acute Kidney Injury Research
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Extracellular vesicles in disease
- Genetic and Kidney Cyst Diseases
- Pain Mechanisms and Treatments
- Electrolyte and hormonal disorders
- Adipose Tissue and Metabolism
- Tissue Engineering and Regenerative Medicine
- Neuropeptides and Animal Physiology
- Hair Growth and Disorders
- Analytical Chemistry and Chromatography
- Neurological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Chronic Kidney Disease and Diabetes
- Mesenchymal stem cell research
- Metabolomics and Mass Spectrometry Studies
- RNA regulation and disease
- Animal Nutrition and Physiology
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Panjab University
2012-2025
National Institute of Pharmaceutical Education and Research
2023
University of the Punjab
2020-2022
P. D. Hinduja Hospital and Medical Research Centre
2018
Center for Systems Biology
2012
University of Kansas Medical Center
1999-2006
University of Kansas
2005
Post Graduate Institute of Medical Education and Research
1997
All India Institute of Medical Sciences
1977-1986
The Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) represent family structurally-related eukaryotic transcription factors which regulate diverse array cellular processes including immunological responses, inflammation, apoptosis, growth & development. Increased expression NF-kB has often been seen in many diseases, suggesting the importance genomic deregulation to disease pathophysiology. In present study we focused on acute kidney injury (AKI), remains one major risk...
The pharmacokinetics of progesterone (dose: 10 microgram per animal) were studied in blood and cerebrospinal fluid adult ovariectomized rhesus monkeys after the administration steroid as an intravenous injection, infusion (duration infusion: min), or nasal spray. bioavailability progesterone, terms area under time--concentration curve maximal concentration two body fluids, was significantly higher when infused sprayed intranasally than it injected intravenously. clearance from serum,...
Carbon nanotubes (CNTs) hold tremendous potential due to their unique and modifiable properties. Their robust biological applications necessitate minimizing cytotoxicity increasing the solubilization. In present manuscript, we have functionalized multiwalled carbon (MWCNTs) using defect functionalization methodology covalently bind carboxy amino groups on walls. This was reassured through fourier-transform infrared spectroscopy (FTIR), energy dispersive x-ray analysis (EDX), elemental field...
The multi-cellular nature of renal tissue makes it the most challenging organ for regeneration. Therefore, till date whole transplantations remain definitive treatment end stage disease (ESRD). shortage available organs transplantation has, thus, remained a major concern as well an unsolved problem. In this regard generation scaffold through decellularization followed by regeneration recellularization is being viewed potential alternative generating functional tissues. Despite its growing...
Abstract. The present studies were carried out to characterize and compare the acute effects of cage-restraint or administration a mild anaesthetic on serum levels testosterone (T) cortisol (C), prolactin (Prl) bioactive luteinizing hormone (LH) in adult male rhesus monkeys. Serum T declined progressively while C increased 3 sequential blood samples obtained at 20 min intervals from restrained Prl LH remained unaltered. Following single multiple injections ketamine hydrochloride (10 mg/kg)...
The prevalence of migraine is 3-folds higher in females than males, and it intricately related to the levels estrogen. Estrogen may regulate expression metabolic enzymes receptors serotonin also calcitonin gene-related peptide (CGRP), which are implicated pathogenesis.To study effects estrogen on components system CGRP trigeminal ganglia ovariectomized (OVX) rats.OVX rats were administered silastic tubes after 48 h, serum determined. Trigeminal tissues used for RT-PCRs tryptophan hydroxylase...
Bioprinting is a multidisciplinary and interdisciplinary field of research where design engineering, materials science, precision automation biology are integrated with biological systems for medical purpose. Through research, devoted efforts in this sector have advanced technology to newer frontiers, giving many fresh approaches reproduce the complex microenvironment required by cells promote their growth, migration, differentiation. This article articulates process three-dimensional (3D)...
To find the novel genes/proteins and their cross talk leading to chronic kidney injury employing integrated in silico vivo approach. National Centre for Biotechnology Information data were used as initial source disease (CKD) genes. Hub genes analyzed through Cytoscape three centrality methods viz. degree, between-ness centrality, maximum neighborhood centrality. Additionally, a master regulator of these was also identified ingenuity pathway analysis. All molecular entities further...
Breast cancer is a highly heterogeneous disorder characterized by dysregulated expression of number genes and their cascades. It one the most common types in women posing serious health concerns globally. Recent developments discovery specific prognostic biomarkers have enabled its application toward developing personalized therapies. The basic premise this study was to investigate key signature signaling pathways involved triple-negative breast using bioinformatics approach. Microarray data...
Although migraine is more common in women than men and often linked to the menstrual cycle, few studies have investigated biological basis of hormonal influences on trigeminovascular system. In present study we effect physiological levels (10(-9) m) oestrogen female rat trigeminal ganglia vitro. Immunocytochemical analysis demonstrated presence receptor-alpha a predominantly cytoplasmic location neurites. Microarray that treatment regulates several genes with potential relevance migraine....
Abstract Heterogeneity in the Diabetic Kidney Disease (DKD) diagnosis makes its rational therapeutics challenging. Although albuminuria characterizes DKD, reports also indicate prevalence among non-proteinuric. Recent understanding of disease progression has thus inclined focus on proximal tubular cell damage besides glomeruli. A non-invasive approach exploiting exosomal miRNA derived from human kidney line was, hence, targeted. Upon profiling, three miRNAs, namely, hsa-miR-155-5p,...
Objectives.—We examined changes in the serotonin system across estrous cycle trigeminal ganglia of female rodents to determine which components are present and regulated by variations levels ovarian steroids that occur during cycle. Background.—Migraine is 2–3 times more prevalent women than men attacks often timed with menstrual cycle, suggesting a mechanistic link steroids. Serotonin has been implicated pathogenesis migraine, effectiveness triptans, selective 5HT‐1B/D/F agonists, provided...
Renal cell carcinoma (RCC), particularly the clear subtype (ccRCC), poses a significant global health concern due to its increasing prevalence and resistance conventional therapies. Early detection of ccRCC remains challenging, resulting in poor patient survival rates. In this study, we employed bioinformatic approach identify potential prognostic biomarkers for kidney renal (KIRC). By analyzing RNA sequencing data from TCGA-KIRC project, differentially expressed genes (DEGs) associated with...
Epigallocatechin gallate (EGCG) is a major component of green tea polyphenols having potent anti-oxidant potential. Besides inhibiting the growth many cancer cell types and inducing proliferation differentiation in keratinocytes, it has been shown to promote reduction body fat. The fact that mesenchymal stem cells (MSCs) have ability self-renew differentiate into mesodermal lineages, such as fat bone, is, thus, possible EGCG may directly be involved affecting metabolism through its effect on...