A5109804127- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Organ Donation and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Organ Transplantation Techniques and Outcomes
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Surgical Simulation and Training
- Facial Nerve Paralysis Treatment and Research
- Histone Deacetylase Inhibitors Research
- Stroke Rehabilitation and Recovery
- Non-Invasive Vital Sign Monitoring
- Vascular Malformations Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Epilepsy research and treatment
Johannes Gutenberg University Mainz
2008-2024
University Medical Center of the Johannes Gutenberg University Mainz
2012-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2017-2021
University of Applied Sciences Mainz
2013-2015
Asklepios Klinik Weißenfels
2012
Object The authors report on their experience with a 3D virtual reality system for planning minimally invasive neurosurgical procedures. Methods Between October 2002 and April 2006, the used Dextroscope (Volume Interactions, Ltd.) to plan procedures in 106 patients, including 100 intracranial 6 spinal lesions. was performed 1 3 days preoperatively, 12 cases, prints of procedure were taken into operating room. A questionnaire completed by neurosurgeon after procedure. Results After short...
Objective Recent studies have investigated the role of spinal image guidance for pedicle screw placement. Many authors observed an elevated placement accuracy and overall improvement outcome measures. This study assessed a bi-institutional experience following introduction Renaissance miniature robot in Europe. Methods The medical records radiographs all patients who underwent robot-guided implantation instrumentation using novel system (between October 2011 March 2015 Mainz February 2014...
Purpose To determine the impact of collateral vessel status on clinical and imaging outcomes in patients undergoing endovascular therapy (EVT) for proximal middle cerebral artery (MCA) occlusion. Materials Methods There were 160 with MCA occlusion at six centers this institutional review board–approved multicenter EVT registry. Angiograms analyzed a blinded core laboratory, was assessed by using American Society Interventional Therapeutic Neuroradiology (ASITN)/Society Radiology (SIR)...
The use of technical aids to confirm brain death is a controversial matter. Angiography with the intra-arterial administration contrast medium international gold standard, but it not allowed in Germany except cases where provides potential mode treatment. currently approved tests are recordings somatosensory evoked potentials (SSEP), perfusion scintigraphy, transcranial Doppler ultrasonography (TCD), and electroencephalography (EEG). CT angiography (CTA), promising new alternative, being...
The localization of epileptic foci is an important issue in children with extratemporal epilepsies. However, the value noninvasive methods such as EEG-assisted functional magnetic resonance imaging (fMRI) has not been sufficiently investigated children. As a model epilepsies, we studied 7 patients aged 5 to 12 (median 10) years benign childhood epilepsy and centrotemporal (rolandic) spikes. Interictal spikes were recorded during fMRI acquisition on MR-compatible battery-powered digital EEG...
Introduction. Papaverine (P) and nimodipine (N) are the most widely used vasodilators when angiographic symptomatic vasospasm is present after subarachnoid aneurysmatic hemorrhage (SAH). Their effect only short-lived no direct comparisons have been undertaken to evaluate action of both substances directly. We retrospectively assessed either P or N on diameter reduction capillary blood flow. Methods. Fifteen SAH patients with secured aneurysms cerebral received intraarterial P, fifteen...
BACKGROUND: Because of its widespread accessibly, computed tomographic angiography (CT-A) is a promising technique in the detection intracranial circulatory arrest brain death (BD). Several studies assessed this tool, but neither have standardized evaluation parameters been developed nor has information about specificity become available. METHODS: We conducted prospective study between January 2008 and April 2012. Thirty patients were admitted to our University Hospital (16 men 14 women;...
The aim of the authors in this study was to introduce a minimally invasive superficial temporal artery middle cerebral (STA-MCA) bypass surgery by preselection appropriate donor and recipient branches 3D virtual reality setting based on 3-T MR angiography data.An STA-MCA anastomosis performed each 5 patients. Before surgery, imaging with magnetization-prepared rapid acquisition gradient echo sequences, high-resolution CT dataset obtained. Image fusion construction model patient were...
Introduction: Balloon angioplasty and/or selective intra-arterial vasodilator therapies are treatment options in patients with vasospasm after subarachnoid hemorrhage (SAH). We analyzed the effect of balloon therapy our patients.Methods: Twenty-six (vasodilation group, VDT) were treated nimodipine. The nimodiopine-group (BAP-N group) comprised 21 patients. primary endpoint this study was successful angiographic vessel dilation vasospastic vessels angioplasty, together nimodipine group),...
Background The endovascular treatment of acute cerebral ischemia has been proven beneficial without major safety concerns. To date, the role in patients treated with oral anticoagulants, which may be associated periprocedural intracranial bleeding, remains uncertain. Aims objective current analysis is to evaluate anticoagulants. Methods ENDOSTROKE-Registry a commercially independent, prospective observational study 12 stroke centers Germany and Austria collecting pre-specified variables...
The EXCELLENT registry aimed to evaluate the effectiveness of EMBOTRAP Revascularization Device in an all-comer population a real-world setting, with focus on composition retrieved clots. is prospective, global patients acute ischemic stroke treated as first-line mechanical thrombectomy device conducted at 34 sites (25 contributing clot) from September 2018 March 2021, utilizing core imaging and central histology laboratories blinded clinical data, independent 90-day modified Rankin Scale...
BACKGROUND: Because of its widespread accessibly, computed tomographic angiography (CT-A) is a promising technique in the detection intracranial circulatory arrest brain death (BD). Several studies assessed this tool, but neither have standardized evaluation parameters been developed nor has information about specificity become available. METHODS: We conducted prospective study between January 2008 and April 2012. Thirty patients were admitted to our University Hospital (16 men 14 women;...
Intracerebral Hemorrhage (IH) is an important cause of secondary brain injury in neurosurgical patients. Early identification and treatment improve neurologic outcome. We have tested Near Infrared Spectroscopy (NIRS) as alternative noninvasive diagnostic tool compared to CT-Scans detect IH. prospectively studied 212 patients with symptoms associated intracranial pathology before performing a CT-scan. NIRS signals indicated pathologies 181 cases (sensitivity 0.96; specificity 0.29). In...
Background: EXCELLENT (NCT03685578) is a large, prospective, single-arm, multicenter, international registry of mechanical thrombectomy (MT) with EmboTrap as the first attempted device in routine clinical practice. The study collects per pass data on procedural and technical details that are based interventionalists’ preference, providing an opportunity to assess current practices MT across multiple high-volume stroke centers. Methods: Subjects treated according standard care were eligible...
Background: Recent stroke clinical trials demonstrate the profound impact of collaterals, yet time constraints are often cited as rationale for not evaluating or imaging collaterals prior to endovascular therapy (EVT). We examined role on patient outcomes in a large registry EVT, analyzing actual required obtain such data before treatment various occlusion sites and monitoring potential harm. Methods: ENDOSTROKE is an industry-independent, centrally-monitored multicenter EVT routine...