A5082372509- Liver physiology and pathology
- Autoimmune and Inflammatory Disorders
- Mobile Health and mHealth Applications
- Pancreatic function and diabetes
- Psoriasis: Treatment and Pathogenesis
- Global Health Care Issues
- Spondyloarthritis Studies and Treatments
- Organ Transplantation Techniques and Outcomes
- Primary Care and Health Outcomes
- Cancer Cells and Metastasis
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Healthcare Systems and Reforms
- Healthcare Policy and Management
- Epigenetics and DNA Methylation
- Cutaneous lymphoproliferative disorders research
- Mechanisms of cancer metastasis
- Reconstructive Facial Surgery Techniques
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Health Literacy and Information Accessibility
- Genetic and rare skin diseases.
- Patient-Provider Communication in Healthcare
- Fibroblast Growth Factor Research
- Global Health Workforce Issues
University Medical Centre Mannheim
2017-2025
Heidelberg University
2017-2025
University Hospital Heidelberg
2017-2025
Medizinische Fakultät Mannheim
2018-2024
Heidelberg University
2024
University Medical Center
2019-2024
Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment. ECs instruct neighboring in vascular niches through angiocrine factors, which include secreted growth factors (angiokines), extracellular matrix molecules, and transmembrane proteins. However, the molecular regulators that drive microvascular transcriptional programs thereby regulate angiodiversity largely elusive. In contrast to other ECs, form a continuous cell layer,...
Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult size metabolic zonation. The cellular origin ligands responsible for homeostatic liver/body weight ratio (LW/BW) remained unclear, which was also attributable to a lack suitable endothelial Cre driver mice. To comprehensively analyze the effects hepatic angiocrine on functions,...
The interaction of tumor cells with organ-specific endothelial (EC) is an important step during metastatic progression. Notch signaling in niches has been implicated mediating opposing effects on organotropic metastasis to the lungs and liver, respectively. In this study, we scrutinized role activation liver metastasis. To target hepatic EC (HEC), a novel subtype-specific Cre driver mouse was generated. Clec4g-Cretg/wt mice were crossed Rosa26N1ICD-IRES-GFP enhance HEC (NICDOE-HEC)....
Psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) are complex, multifactorial diseases significantly impacting health quality of life. Predicting treatment response disease progression is crucial for optimizing therapeutic interventions, yet challenging. Automated machine learning (AutoML) technology shows promise rapidly creating accurate predictive models based on patient features data.
In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic diseases such as dysfunction-associated steatotic disease (MASLD) and steatohepatitis (MASH), this study investigated impact of sinusoidal endothelial cell (LSEC)-specific alterations MASLD/MASH on hepatic melanoma metastasis. Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated fibrosis, or...
Liver sinusoidal endothelial cells (LSECs) control organ functions, metabolism, and development through the secretion of angiokines. LSECs express hepatocyte growth factor (Hgf), which is involved in prenatal development, metabolic homeostasis, liver regeneration. This study aimed to elucidate precise contribution LSEC-derived Hgf physiological homeostasis Stab2-iCretg/wt;Hgffl/fl (HgfΔLSEC) mice were generated abrogate expression selectively from early fetal onwards, global zonation,...
Background and Aims: In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with mutations in the Activin A Receptor‐Like Type 1 ( ACVRL1 ) gene encoding ALK1, receptor for bone morphogenetic protein (BMP) 9/BMP10, which regulates blood vessel development. Here, we established an HHT mouse model exclusive involvement adequate life expectancy to investigate ALK1 signaling formation metabolic function. Approach Results: Liver sinusoidal endothelial...
The application of machine learning (ML) for use in generating insights and making predictions on new records continues to expand within the medical community. Despite this progress date, time series analysis has remained underexplored due complexity underlying techniques. In study, we have deployed a novel ML, called automated (AutoTS) learning, automate data processing multitude models assess which best forecasts future values. This rapid experimentation allows enables selection most...
Abstract Brahma-related gene 1 (Brg1), a catalytic subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, is known to be involved in proliferative cell processes. Liver regeneration initiated spontaneously after injury and leads strong response. In this study, hepatocyte-specific Brg1 knockout mouse model was used analyse role liver by performing 70% partial hepatectomy (PH). After PH, significantly upregulated wildtype mice. Mice with showed lower body weight ratio 48 h post-PH...
Psoriasis is a chronic inflammatory skin disease. The visibility of erythematous plaques on the as well pain and itchiness caused by lesions frequently leads to psychological distress in patients. Smartphone apps are widespread easily accessible. Earlier studies have shown that can effectively complement current management strategies for patients with psoriasis. However, no analysis such has been published date.The aim this study systematically identify objectively assess quality publicly...
The Romanian health system is struggling to retain its workers, who are currently facing strong incentives for migration Western European systems. Retention issues, coupled with high levels of migration, complicate Romania's efforts in providing basic services rural, underserved, and marginalized populations, as well achieving equitable access all. WHO Global Code Practice on International Recruitment Health Personnel (the Code) aims promote ethical international recruitment systems...
Abstract Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce formation. Here, we show that BM sinusoidal (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC ( Ctnnb1 OE-SEC ) generated by using a BM-SEC-restricted Cre mouse line Stab2-iCreF3 develop fatal anemia. While activation of Wnt-signaling causes an increase erythroblast subsets (PII–PIV), mature...
Psoriatic arthritis (PsA), a disease with complex inflammatory musculoskeletal manifestations, complicates psoriasis in up to 30% of patients. In this study, we aimed determine the effect an interdisciplinary dermatological-rheumatological consultation (IDRC) for patients symptoms. This prospective study enrolled 202 psoriasis. Patients pain (MSP) (n = 115) participated IDRC 12 weeks after enrollment. The outcome was evaluated 24 weeks. 12/79 (15.2%) seen IDRC, prior diagnosis changed: eight...
Noncommunicable diseases (NCDs) and maternal newborn child health (MNCH) are two deeply intertwined areas that have been artificially separated by global policies, resource allocations programming. Optimal MNCH care can provide a unique opportunity to screen for, prevent manage early signs of NCDs developing in both the woman neonate. This paper considers how NCDs, NCD modifiable risk factors, metabolic factors impact MNCH. We argue integrated management is essential, but this faces...
Rapid digitalization in health care has led to the adoption of digital technologies; however, limited trust internet-based decisions and need for technical personnel hinder use smartphones machine learning applications. To address this, automated (AutoML) is a promising tool that can empower professionals enhance effectiveness mobile apps.
Background Rheumatic immune-related adverse events (R-irAEs) occur in 5–15% of patients receiving immune checkpoint inhibitors (ICI) and, unlike other irAEs, tend to be chronic. Herein, we investigate the factors influencing cancer and R-irAEs outcomes with particular focus on effects anti-inflammatory treatment. Methods In this prospective, multicenter, long-term, observational study, were comprehensively analyzed malignant melanoma (MM, n=50) non-small cell lung (NSCLC, n=41) ICI therapy...
The epidemiology of neglected tropical diseases (NTD) is persistently underprioritized, despite NTD being widespread among the poorest populations and in least developed countries on earth. This situation necessitates thorough efficient public health intervention. Romania at brink becoming a country. However, this South-Eastern European country appears to be region that susceptible an underestimated burden parasitic recent reforms. Moreover, there evident lack new epidemiologic data after...
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Background: The exceptional changes in the Romanian society after 1989 have strongly influenced thereforms of health system.Methods: Several tools were used for this policy review: finding evidence to prove that there areimportant public problems Romania, as well reviewing existing legislation and papersrelated system, stakeholder analysis, meetings working groups with key players from healthsector.Results: Health indicators Romania are some poorest WHO European region, not only at EUlevel....