A5071901031- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Kruppel-like factors research
- Liver physiology and pathology
- FOXO transcription factor regulation
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Vascular Anomalies and Treatments
- Clusterin in disease pathology
- Endoplasmic Reticulum Stress and Disease
- Erythrocyte Function and Pathophysiology
- Congenital heart defects research
- Mesenchymal stem cell research
Heidelberg University
2020-2022
University Hospital Heidelberg
2020-2022
University Medical Centre Mannheim
2020-2022
National Chung Hsing University
2021
Angiocrine signaling by liver sinusoidal endothelial cells (LSECs) regulates hepatic functions such as growth, metabolic maturation, and regeneration. Recently, we identified GATA4 the master regulator of LSEC specification during development. Herein, studied role in adult pathogenesis.We generated Clec4g-icretg/0xGata4fl/fl (Gata4LSEC-KO) mice with LSEC-specific depletion Gata4. Livers were analyzed histology, electron microscopy, immunohistochemistry/immunofluorescence, situ hybridization,...
Background and Aims: In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with mutations in the Activin A Receptor‐Like Type 1 ( ACVRL1 ) gene encoding ALK1, receptor for bone morphogenetic protein (BMP) 9/BMP10, which regulates blood vessel development. Here, we established an HHT mouse model exclusive involvement adequate life expectancy to investigate ALK1 signaling formation metabolic function. Approach Results: Liver sinusoidal endothelial...
Lung cancer is heterogeneous and challenging to cope with once it has progressed. Chemotherapy the first step no active driver mutation been discovered. Non-antitumor drugs have found be beneficial when used as adjuvants chemotherapy. In this study, additive effect mechanism of metformin combined pemetrexed in non-small-cell lung (NSCLC) cells were elucidated. Three NSCLC cell lines, A549, H1975, HCC827, analyze tumor proliferation, colony formation cycle vitro exposed alone, alone or their...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for alternative tumor-targeted treatment. Human amniotic fluid mesenchymal stem cells (hAFMSCs) have been revealed suppress tumor growth in various cancers they are strong candidate treating PDAC. Methods To evaluate effects of hAFMSCs on human pancreatic carcinoma (PANC1, AsPC1 BxPC3 cell lines) possible mechanism involved, an vitro...
Abstract Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce formation. Here, we show that BM sinusoidal (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC ( Ctnnb1 OE-SEC ) generated by using a BM-SEC-restricted Cre mouse line Stab2-iCreF3 develop fatal anemia. While activation of Wnt-signaling causes an increase erythroblast subsets (PII–PIV), mature...
Osteoporosis is a rising health threat in the increasingly aging world population. It common skeletal disease strongly linked to genetic predisposition. We aim identify effects of anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on risk for osteoporosis. investigated analyzed relationships between three TGF-β1 SNPs (−509C/T, +869 T/C +29T/C), one IL-10 SNP (+1927A/C) level bone mineral density (BMD), as well osteoporosis Taiwanese osteoporotic...
Hypopharyngeal squamous cell carcinoma (HSCC) is usually diagnosed at an advanced stage, leading to a poor prognosis. Even after improvement of surgical techniques, chemotherapy, and radiation technology, the survival rate HSCC remains poor. Metformin, which commonly used for type 2 diabetes mellitus (DM), has been suggested reduce risk various cancer types. However, only few clinical studies mentioned relationship between metformin use HSCC. Hence, aim this study was elucidate specific...
Lung cancer remains a challenge in daily practice. Chemotherapy is first considered for advanced lung adenocarcinoma bearing no active driver mutations. Maintaining drug efficacy and overcoming resistance are essential. This study aimed to explore the real-world use of anti-diabetic agent metformin combination with pemetrexed-based platinum doublets first-line setting. We retrospectively collected data during 2004~2013 from TaiwaN′s National Health Insurance Research Database access survival...
Endothelial wingless-related integration site (Wnt)-/β-catenin signaling is a key regulator of the tightly sealed blood–brain barrier. In hepatic vascular niche angiokine-mediated Wnt was recently identified as an important hepatocyte function, including determination final adult liver size, regeneration, and metabolic zonation. Within vasculature, sinusoidal endothelial cells (LSECs) are morphologically unique functionally specialized microvascular (ECs). Pathological changes LSECs involved...